KEGG   PATHWAY: mun04630
Entry
mun04630                    Pathway                                
Name
JAK-STAT signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04630  JAK-STAT signaling pathway
mun04630

Other DBs
GO: 0007259
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110545874  Il2; interleukin-2 [KO:K05429]
110560079  interleukin-2-like [KO:K05429]
110548759  Il4; interleukin-4 [KO:K05430]
110556314  Il7; interleukin-7 [KO:K05431]
110557059  Il9; interleukin-9 [KO:K05432]
110562738  Il15; interleukin-15 isoform X1 [KO:K05433]
110545880  Il21; interleukin-21 [KO:K05434]
110565470  Tslp; thymic stromal lymphopoietin [KO:K05436]
110556899  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110548465  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110564656  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
110564641  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
110561264  Il9r; interleukin-9 receptor isoform X1 [KO:K05073]
110556898  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
110564645  Il21r; interleukin-21 receptor [KO:K05075]
110561719  interleukin-3-like [KO:K04736]
110548757  Il5; interleukin-5 [KO:K05428]
110561713  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110543786  Il3ra; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
110555889  Il5ra; interleukin-5 receptor subunit alpha [KO:K05067]
110566611  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
110548450  Csf2rb; cytokine receptor common subunit beta [KO:K04738]
110539463  Il6; interleukin-6 [KO:K05405]
110561070  Il11; interleukin-11 [KO:K05417]
110548783  Il13; interleukin-13 [KO:K05435]
110547944  Il27; interleukin-27 subunit alpha isoform X1 [KO:K22629]
110545309  Il31; interleukin-31 [KO:K22631]
110557889  Osm; oncostatin-M isoform X2 [KO:K05418]
110557820  Lif; leukemia inhibitory factor isoform X1 [KO:K05419]
110565759  Cntf; ciliary neurotrophic factor [KO:K05420]
110559789  cardiotrophin-1 isoform X2 [KO:K05422]
110559794  cardiotrophin-2 [KO:K24382]
110560353  Clcf1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
110546647  Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
110547120  Il11ra; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056]
110566908  Il13ra1; interleukin-13 receptor subunit alpha-1 isoform X3 [KO:K05076]
110540890  Il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
110545804  Il27ra; interleukin-27 receptor subunit alpha [KO:K19598]
110546653  Il31ra; interleukin-31 receptor subunit alpha [KO:K22630]
110557587  Lifr; leukemia inhibitory factor receptor [KO:K05058]
110547128  Cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
110550319  Il10; interleukin-10 [KO:K05443]
110550306  Il19; interleukin-19 [KO:K05444]
110561826  Il22; interleukin-22 [KO:K05445]
110550303  Il20; interleukin-20 isoform X1 [KO:K22667]
110550316  Il24; interleukin-24 isoform X1 [KO:K22668]
110549113  Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
110541906  Il10rb; interleukin-10 receptor subunit beta [KO:K05135]
110539321  Il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
110555020  Il20rb; interleukin-20 receptor subunit beta [KO:K05137]
110545421  Il22ra1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
110557644  Il22ra2; interleukin-22 receptor subunit alpha-2 isoform X3 [KO:K05139]
110557307  Il12a; interleukin-12 subunit alpha [KO:K05406]
110548438  Il12b; interleukin-12 subunit beta [KO:K05425]
110559386  Il23a; interleukin-23 subunit alpha [KO:K05426]
110549207  Il12rb1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
110555653  Il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
110539462  Il23r; interleukin-23 receptor [KO:K05065]
110556771  Epo; erythropoietin isoform X2 [KO:K05437]
110547057  somatotropin [KO:K05438]
110563396  prolactin-3D4-like [KO:K05439]
110542667  prolactin-3D4-like [KO:K05439]
110542666  prolactin-3D4-like [KO:K05439]
110543443  prolactin-6A1-like [KO:K05439]
110564591  prolactin-2C2-like [KO:K05439]
110564593  prolactin-2A1-like [KO:K05439]
110564594  prolactin-7C1-like [KO:K05439]
110563397  prolactin-like isoform X1 [KO:K05439]
110563905  prolactin-5A1-like [KO:K05439]
110549398  Thpo; thrombopoietin isoform X1 [KO:K06854]
110558489  Csf3; granulocyte colony-stimulating factor [KO:K05423]
110562957  Lep; leptin [KO:K05424]
110552478  Epor; erythropoietin receptor isoform X1 [KO:K05079]
110563813  Ghr; growth hormone receptor [KO:K05080]
110566621  Prlr; prolactin receptor isoform X1 [KO:K05081]
110552930  Mpl; thrombopoietin receptor isoform X1 [KO:K05082]
110540287  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
110559039  Lepr; leptin receptor isoform X1 [KO:K05062]
110544130  interferon alpha-1-like [KO:K05414]
110543198  interferon alpha-1-like [KO:K05414]
110543200  interferon alpha-1-like [KO:K05414]
110544870  interferon alpha-2-like [KO:K05414]
110544619  interferon alpha-1-like [KO:K05414]
132646742  interferon alpha-1-like [KO:K05414]
132646744  interferon alpha-11-like [KO:K05414]
132646745  interferon alpha-1-like [KO:K05414]
132646746  interferon alpha-1-like [KO:K05414]
132646775  interferon alpha-11-like [KO:K05414]
110541303  Ifnb1; interferon beta [KO:K05415]
110543506  Ifne; interferon epsilon [KO:K05442]
110551847  Ifnk; interferon kappa [KO:K05441]
110552536  interferon lambda-2-like [KO:K22669]
132647077  interferon lambda-2-like [KO:K22669]
110541917  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
110541888  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
110545417  Ifnlr1; interferon lambda receptor 1 [KO:K05140]
110561827  Ifng; interferon gamma [KO:K04687]
110557641  Ifngr1; interferon gamma receptor 1 [KO:K05132]
110541673  Ifngr2; interferon gamma receptor 2 [KO:K05133]
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110555551  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110547004  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110549202  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110555765  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
110552020  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
110559388  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110550916  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110552026  Stat4; signal transducer and activator of transcription 4 [KO:K11222]
110550874  signal transducer and activator of transcription 5A [KO:K11223]
110550889  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
110561573  Stat6; signal transducer and activator of transcription 6 isoform X2 [KO:K11225]
110556519  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110564569  Cish; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
110555271  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
110562882  Socs2; suppressor of cytokine signaling 2 isoform X1 [KO:K04695]
110550317  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
110550951  Socs4; suppressor of cytokine signaling 4 [KO:K04697]
110561838  Socs5; suppressor of cytokine signaling 5 [KO:K04698]
110554277  Socs7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
110562654  Socs6; suppressor of cytokine signaling 6 [KO:K04699]
110557800  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110556651  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
110550083  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110546587  Pim1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110546940  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
110548628  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110550225  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
110546586  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110559600  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
110559602  aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
110559604  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
110559605  aldehyde oxidase 4 isoform X1 [KO:K00157] [EC:1.2.3.1]
110545655  Gfap; glial fibrillary acidic protein isoform X1 [KO:K05640]
110561775  Stam; signal transducing adapter molecule 1 [KO:K04705]
110559375  Stam2; signal transducing adapter molecule 2 [KO:K04705]
110562689  Ptpn2; tyrosine-protein phosphatase non-receptor type 2 isoform X2 [KO:K18026] [EC:3.1.3.48]
110548584  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
110554089  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110545943  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110550529  Pias1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
110564806  Pias2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063] [EC:2.3.2.-]
110562520  E3 SUMO-protein ligase PIAS2-like [KO:K16063] [EC:2.3.2.-]
110560313  Pias3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
110555610  Pias4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
110566913  Fhl1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
110561957  four and a half LIM domains protein 1-like [KO:K14365]
110546380  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
110547825  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
110547073  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110556913  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110548161  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
mun04010  MAPK signaling pathway
mun04060  Cytokine-cytokine receptor interaction
mun04110  Cell cycle
mun04120  Ubiquitin mediated proteolysis
mun04151  PI3K-Akt signaling pathway
mun04210  Apoptosis
KO pathway
ko04630   
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