KEGG   PATHWAY: mun04151
Entry
mun04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04151  PI3K-Akt signaling pathway
mun04151

Other DBs
GO: 0043491
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539385  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
110539463  Il6; interleukin-6 [KO:K05405]
110539533  Fgf16; fibroblast growth factor 16 [KO:K04358]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110540164  Col4a5; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237]
110540240  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110540260  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110540287  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
110540697  [KO:K06071] [EC:2.7.11.13]
110540777  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110541171  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110541303  Ifnb1; interferon beta [KO:K05415]
110541403  Itga10; integrin alpha-10 [KO:K06586]
110541773  Tlr2; toll-like receptor 2 [KO:K10159]
110541888  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
110541917  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
110542126  Vegfc; vascular endothelial growth factor C [KO:K05449]
110542391  Ptk2; focal adhesion kinase 1 isoform X4 [KO:K05725] [EC:2.7.10.2]
110542459  Mtcp1; protein p13 MTCP-1 [KO:K16837]
110542507  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110542666  [KO:K05439]
110542667  [KO:K05439]
110543198  [KO:K05414]
110543200  [KO:K05414]
110543443  [KO:K05439]
110543786  Il3ra; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
110543906  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110544130  [KO:K05414]
110544619  [KO:K05414]
110544642  [KO:K07828]
110544653  [KO:K04467] [EC:2.7.11.10]
110544765  Nras; GTPase NRas [KO:K07828]
110544846  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
110545060  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
110545481  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110545505  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110545561  Ntf3; neurotrophin-3 [KO:K04356]
110545659  Itgb3; integrin beta-3 [KO:K06493]
110545672  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110545702  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
110545821  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110545848  Pkn1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
110545874  Il2; interleukin-2 [KO:K05429]
110545886  Fgf2; fibroblast growth factor 2 [KO:K18497]
110546030  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 [KO:K16340] [EC:3.1.3.16]
110546189  Lamc1; laminin subunit gamma-1 [KO:K05635]
110546194  Lamc2; laminin subunit gamma-2 [KO:K06246]
110546214  Pspn; persephin [KO:K25416]
110546254  Nrtn; neurturin isoform X2 [KO:K25414]
110546347  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110546356  Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
110546441  Fgf3; fibroblast growth factor 3 [KO:K04358]
110546517  Fgf19; fibroblast growth factor 19 [KO:K22603]
110546548  Fgf4; fibroblast growth factor 4 [KO:K04358]
110546586  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110546688  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110546690  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110546940  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
110546968  Pgf; placenta growth factor [KO:K16859]
110547004  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110547057  [KO:K05438]
110547073  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110547163  Tgfa; protransforming growth factor alpha [KO:K08774]
110547261  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110547298  Ins; insulin [KO:K04526]
110547372  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110547488  Ywhae; 14-3-3 protein epsilon [KO:K06630]
110547502  Irs1; insulin receptor substrate 1 isoform X1 [KO:K16172]
110547507  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
110547508  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
110547784  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
110547817  Fgf18; fibroblast growth factor 18 [KO:K04358]
110547825  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
110547925  Itgb4; integrin beta-4 isoform X3 [KO:K06525]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110548014  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
110548161  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110548204  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
110548219  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
110548220  Sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
110548328  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110548465  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110548560  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110548577  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110548579  Vwf; von Willebrand factor [KO:K03900]
110548616  Fgf6; fibroblast growth factor 6 [KO:K04358]
110548628  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110548635  Fgf23; fibroblast growth factor 23 [KO:K22428]
110548730  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110548759  Il4; interleukin-4 [KO:K05430]
110548883  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
110548884  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
110549018  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110549164  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110549169  Comp; cartilage oligomeric matrix protein [KO:K04659]
110549176  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110549202  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110549233  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110549337  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110549625  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110549737  Fgf9; fibroblast growth factor 9 [KO:K04358]
110549775  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110549781  Eif4e1b; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 1B [KO:K03259]
110549859  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
110549884  Itgb6; integrin beta-6 [KO:K06589]
110549942  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
110550003  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110550083  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110550131  Vtn; vitronectin isoform X2 [KO:K06251]
110550171  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
110550186  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
110550189  [KO:K06238]
110550200  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110550225  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
110550362  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110550381  [KO:K05462]
110550406  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
110550419  Sgk1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
110550451  Fgf10; fibroblast growth factor 10 [KO:K04358]
110550501  Fgf21; fibroblast growth factor 21 [KO:K22429]
110550525  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110550539  Itga11; integrin alpha-11 [KO:K06587]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110550703  Tsc1; hamartin isoform X1 [KO:K07206]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110550902  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
110550903  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
110551008  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110551097  F2r; proteinase-activated receptor 1 [KO:K03914]
110551197  Itga3; integrin alpha-3 isoform X2 [KO:K06482]
110551201  Col1a1; collagen alpha-1(I) chain [KO:K06236]
110551211  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110551350  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110551353  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110551374  Efna2; ephrin-A2 [KO:K05462]
110551437  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110551598  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110551603  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110551705  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
110551706  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
110551766  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110551875  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
110551893  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
110552024  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110552062  Chad; chondroadherin [KO:K06248]
110552201  Itga4; integrin alpha-4 [KO:K06483]
110552267  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
110552284  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
110552295  Lama1; laminin subunit alpha-1 [KO:K05637]
110552301  Itgb7; integrin beta-7 [KO:K06590]
110552302  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
110552352  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
110552478  Epor; erythropoietin receptor isoform X1 [KO:K05079]
110552526  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110552573  Thbs2; thrombospondin-2 [KO:K04659]
110552616  Angpt1; angiopoietin-1 isoform X2 [KO:K05465]
110552633  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110552849  Sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
110552932  Artn; artemin isoform X1 [KO:K25415]
110552948  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110552966  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110553013  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110553023  Tsc2; tuberin isoform X1 [KO:K07207]
110553027  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110553235  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
110553236  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
110553430  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110553478  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
110553533  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
110553593  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110553742  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110553748  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110553868  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110554009  Lama5; laminin subunit alpha-5 [KO:K06240]
110554214  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110554243  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
110554250  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110554354  Tnr; tenascin-R isoform X2 [KO:K06252]
110554808  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110554841  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110554946  Fgfr2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
110554970  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
110555127  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110555390  Gsk3b; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
110555551  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110555572  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110555606  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110555614  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
110555699  Foxo3; forkhead box protein O3 [KO:K09408]
110555733  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
110555779  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
110555822  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
110555839  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
110555864  Ywhag; 14-3-3 protein gamma [KO:K16198]
110556144  Rps6; small ribosomal subunit protein eS6 [KO:K02991]
110556251  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110556314  Il7; interleukin-7 [KO:K05431]
110556367  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110556525  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
110556579  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110556613  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110556649  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
110556651  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110556769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110556771  Epo; erythropoietin isoform X2 [KO:K05437]
110556776  Fgf8; fibroblast growth factor 8 isoform X4 [KO:K04358]
110556827  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110556868  Col1a2; collagen alpha-2(I) chain [KO:K06236]
110556884  Thbs3; thrombospondin-3 isoform X2 [KO:K04659]
110556899  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110556913  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110556944  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110556971  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110557288  Fn1; fibronectin isoform X1 [KO:K05717]
110557305  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110557441  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110557450  Ywhah; 14-3-3 protein eta [KO:K16198]
110557460  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110557477  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110557573  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
110557599  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
110557636  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
110557688  Itga9; integrin alpha-9 [KO:K06585]
110557800  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110557889  Osm; oncostatin-M isoform X2 [KO:K05418]
110557978  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110558019  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110558140  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110558300  Lpar3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
110558380  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110558424  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110558489  Csf3; granulocyte colony-stimulating factor [KO:K05423]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110558629  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110558972  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
110558987  Lamb1; laminin subunit beta-1 [KO:K05636]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110559141  Nr4a1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X1 [KO:K04465]
110559159  Itgav; integrin alpha-V [KO:K06487]
110559223  Lama2; laminin subunit alpha-2 [KO:K05637]
110559252  Lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
110559281  Kitlg; kit ligand isoform X1 [KO:K05461]
110559284  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110559286  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110559335  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
110559352  Angpt2; angiopoietin-2 [KO:K05466]
110559383  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110559398  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110559682  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
110559812  Lamb3; laminin subunit beta-3 isoform X3 [KO:K06244]
110559917  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110560079  [KO:K05429]
110560093  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
110560104  Tnxb; tenascin-X isoform X1 [KO:K06252]
110560146  Areg; amphiregulin [KO:K09782]
110560157  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110560360  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110560607  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110560640  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
110560656  Ntf4; neurotrophin-4 [KO:K12457]
110560695  Myb; transcriptional activator Myb isoform X4 [KO:K09420]
110560872  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
110561085  Itga2; integrin alpha-2 [KO:K06481]
110561134  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110561175  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110561220  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
110561245  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110561277  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110561302  Thbs4; thrombospondin-4 [KO:K04659]
110561393  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
110561622  Igf1; insulin-like growth factor I isoform X5 [KO:K05459]
110561719  [KO:K04736]
110561882  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
110562176  Gys2; glycogen [starch] synthase, liver isoform X3 [KO:K00693] [EC:2.4.1.11]
110562241  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
110562528  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
110562552  Nos3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
110562821  Spp1; osteopontin [KO:K06250]
110562822  Ibsp; bone sialoprotein 2 [KO:K06253]
110562952  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110563129  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110563160  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
110563280  Itga6; integrin alpha-6 isoform X3 [KO:K06485]
110563307  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110563345  Tnn; tenascin-N [KO:K06252]
110563396  [KO:K05439]
110563397  [KO:K05439]
110563491  Tnc; tenascin isoform X1 [KO:K06252]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110563813  Ghr; growth hormone receptor [KO:K05080]
110563905  [KO:K05439]
110563924  Hsp90b1; endoplasmin [KO:K09487]
110564033  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
110564049  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
110564212  Ywhaq; 14-3-3 protein theta [KO:K16197]
110564258  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110564316  Fgf20; fibroblast growth factor 20 [KO:K04358]
110564378  Ngf; beta-nerve growth factor [KO:K02582]
110564591  [KO:K05439]
110564593  [KO:K05439]
110564594  [KO:K05439]
110564627  [KO:K10167]
110564629  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110564641  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
110564656  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
110564688  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110564967  Lama4; laminin subunit alpha-4 [KO:K06241]
110564977  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110565064  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110565075  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110565083  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110565216  Lamb2; laminin subunit beta-2 [KO:K06243]
110565263  Ereg; proepiregulin [KO:K09784]
110565312  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110565332  Tlr4; toll-like receptor 4 [KO:K10160]
110565383  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
110565673  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
110565679  Them4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
110565703  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110565714  Rheb; GTP-binding protein Rheb [KO:K07208]
110565735  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
110565800  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
110565807  [KO:K02991]
110565822  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
110565823  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110566621  Prlr; prolactin receptor isoform X1 [KO:K05081]
132646742  [KO:K05414]
132646744  [KO:K05414]
132646745  [KO:K05414]
132646746  [KO:K05414]
132646775  [KO:K05414]
132649468  [KO:K02991]
132652364  [KO:K02991]
132655066  [KO:K10167]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mun00010  Glycolysis / Gluconeogenesis
mun04010  MAPK signaling pathway
mun04012  ErbB signaling pathway
mun04062  Chemokine signaling pathway
mun04064  NF-kappa B signaling pathway
mun04068  FoxO signaling pathway
mun04110  Cell cycle
mun04115  p53 signaling pathway
mun04150  mTOR signaling pathway
mun04210  Apoptosis
mun04370  VEGF signaling pathway
mun04510  Focal adhesion
mun04620  Toll-like receptor signaling pathway
mun04630  JAK-STAT signaling pathway
mun04662  B cell receptor signaling pathway
mun04910  Insulin signaling pathway
KO pathway
ko04151   

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