KEGG   PATHWAY: nni04148
Entry
nni04148                    Pathway                                
Name
Efferocytosis - Nipponia nippon (crested ibis)
Class
Cellular Processes; Transport and catabolism
Pathway map
nni04148  Efferocytosis
nni04148

Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104008738  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104008742  STAB1; stabilin-1 [KO:K19020]
104008826  SGK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
104009062  [KO:K07293] [EC:3.1.3.48]
104009420  ANO3; anoctamin-3 [KO:K19498]
104009493  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
104009499  ANO5; anoctamin-5 [KO:K19480]
104009628  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
104009665  XKR9; XK-related protein 9 [KO:K26814]
104009696  [KO:K08268]
104009874  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104009899  ITGB3; integrin beta-3 [KO:K06493]
104010118  [KO:K08057]
104010140  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
104010205  RAB17; ras-related protein Rab-17 [KO:K07909]
104010208  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104010304  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
104010322  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
104010338  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104010430  PBX1; pre-B-cell leukemia transcription factor 1 [KO:K09355]
104010665  VPS8; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
104010691  ANO7; anoctamin-7 [KO:K19501]
104010702  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104010749  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
104010750  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104010773  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104011179  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
104011197  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
104011202  C1QA; complement C1q subcomponent subunit A [KO:K03986]
104011204  C1QC; complement C1q subcomponent subunit C [KO:K03988]
104011205  C1QB; complement C1q subcomponent subunit B [KO:K03987]
104011297  [KO:K00411] [EC:7.1.1.8]
104011302  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
104011408  ANO9; anoctamin-9 [KO:K19503]
104011434  CRKL; crk-like protein [KO:K04438]
104011593  PQLC2L; putative uncharacterized protein C3orf55 homolog [KO:K23678]
104011627  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
104011717  ANO4; anoctamin-4 [KO:K19499]
104011942  ABCA1; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 1 [KO:K05641]
104012087  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
104012104  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104012458  [KO:K01370] [EC:3.4.22.36]
104012652  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104012952  ATP11C; phospholipid-transporting ATPase IG [KO:K26934]
104013010  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
104013024  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
104013068  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
104013097  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104013114  IL10; interleukin-10 [KO:K05443]
104013120  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
104013122  RAB7B; ras-related protein Rab-7b [KO:K07898]
104013157  [KO:K01052] [EC:3.1.1.13]
104013179  PPARD; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta [KO:K04504]
104013194  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104013235  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104013374  STAB2; stabilin-2 [KO:K19013]
104013536  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
104013573  [KO:K01052] [EC:3.1.1.13]
104013638  ANO6; anoctamin-6 [KO:K19500]
104013901  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104013967  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104013989  [KO:K01052] [EC:3.1.1.13]
104014074  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
104014097  [KO:K26935]
104014118  CD47; LOW QUALITY PROTEIN: leukocyte surface antigen CD47 [KO:K06266]
104014182  PROS1; vitamin K-dependent protein S [KO:K03908]
104014199  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104014224  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20413]
104014260  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
104014303  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
104014431  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
104014695  XKR6; XK-related protein 6 [KO:K26811]
104015059  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104015299  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
104015304  ITGAV; integrin alpha-V [KO:K06487]
104015522  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
104015598  XKR8; XK-related protein 8 [KO:K26813]
104015768  DNMT3A; LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
104015835  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
104015925  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
104016008  CRK; adapter molecule crk [KO:K04438]
104016069  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
104016115  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104016213  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104016304  ABCA7; ATP-binding cassette sub-family A member 7 [KO:K05641]
104016317  BSG; basigin [KO:K06535]
104016382  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104016462  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104016464  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104016741  SCARF1; LOW QUALITY PROTEIN: scavenger receptor class F member 1 [KO:K24318]
104016847  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
104016939  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
104017047  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104017050  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
104017085  MFGE8; lactadherin isoform X1 [KO:K17253]
104017378  PANX1; pannexin-1 [KO:K03443]
104017466  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
104017470  CX3CL1; fractalkine [KO:K05508]
104018318  XKR7; XK-related protein 7 [KO:K26811]
104018787  ITGB5; integrin beta-5 [KO:K06588]
104018793  CALR3; calreticulin-3 [KO:K08057]
104018809  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104019154  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
104019257  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
104019349  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
104019411  GAS6; growth arrest-specific protein 6 [KO:K05464]
104019418  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934]
104019481  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
104019537  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
104019586  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934]
104019754  XKR4; XK-related protein 4 [KO:K26811]
104020053  [KO:K06551]
104020099  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104020294  THBS1; thrombospondin-1 [KO:K16857]
104020353  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
104020360  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104020385  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
104020415  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
104020439  VPS39; vam6/Vps39-like protein [KO:K20183]
104020473  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
104020567  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104020584  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104020711  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104020754  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
104021286  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104021344  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104021434  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104021606  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
104021716  [KO:K04261]
104021875  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104022032  TMEM30A; cell cycle control protein 50A [KO:K26935]
104022095  [KO:K06834] [EC:3.4.24.-]
104022104  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104022338  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104022374  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104022462  MERTK; LOW QUALITY PROTEIN: tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
104022609  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
104022617  [KO:K04397] [EC:3.4.22.60]
104022657  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
104022717  P2RY6; P2Y purinoceptor 6 [KO:K04272]
104022718  P2RY2; P2Y purinoceptor 2 [KO:K04269]
104022872  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
104022931  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
104023029  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
104023200  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
104023215  RAB14; ras-related protein Rab-14 [KO:K07881]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
nni00010  Glycolysis / Gluconeogenesis
nni04140  Autophagy - animal
nni04145  Phagosome
KO pathway
ko04148   

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