KEGG   PATHWAY: aamp05208
Entry
aamp05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Arvicola amphibius (Eurasian water vole)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
aamp05208  Chemical carcinogenesis - reactive oxygen species
aamp05208

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119811078  As3mt; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
119800665  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
119800819  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
119800820  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
119800821  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
119800822  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119800823  glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119800824  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
119800825  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
119800828  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
119828086  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
119809017  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809018  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809423  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119822331  LOW QUALITY PROTEIN: glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
119822623  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
119822639  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
119809666  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119822842  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
119823006  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
119823076  glutathione S-transferase theta-2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119810380  Gsto2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
119810407  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
119817036  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805014  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805073  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119826537  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
119826538  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
119806887  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
119815378  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119821089  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119823492  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119804764  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119814379  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119808469  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
119821547  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119822367  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119816292  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119817139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119800371  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119808111  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119803343  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119813558  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119807886  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119810302  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
119822816  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119815606  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119825491  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
119819937  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119807526  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119821505  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
119810151  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
119827973  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
119808788  acyl carrier protein, mitochondrial-like [KO:K03955]
119812443  acyl carrier protein, mitochondrial-like [KO:K03955]
119807454  acyl carrier protein, mitochondrial [KO:K03955]
119810775  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119811058  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
119803407  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119813692  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119818574  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
119800598  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
119806913  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
119804078  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119825606  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119825940  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
119825963  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
119801780  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119811753  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
119823332  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119812927  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119804641  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119804932  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119820696  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119827486  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119814166  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119810090  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119809107  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119803219  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810541  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119816982  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119818379  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119825922  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810417  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119821308  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119814511  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119826441  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119802653  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
119809157  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119816786  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119827624  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
119809004  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119816634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119822897  cytochrome c1, heme protein, mitochondrial [KO:K00413]
119810716  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
119818376  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119817782  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119823100  cytochrome b-c1 complex subunit 7 [KO:K00417]
119826150  cytochrome b-c1 complex subunit 7 [KO:K00417]
119812643  cytochrome b-c1 complex subunit 8 [KO:K00418]
119822943  cytochrome b-c1 complex subunit 10 [KO:K00420]
119824516  cytochrome b-c1 complex subunit 10-like [KO:K00420]
119801810  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119815669  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119808969  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119820956  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119800700  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119823348  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119824540  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119813186  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119826874  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119821317  cytochrome c oxidase subunit 6B2 [KO:K02267]
119803616  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119812348  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119820632  cytochrome c oxidase subunit 6B1 [KO:K02267]
119823502  cytochrome c oxidase subunit 6C-2 [KO:K02268]
119804134  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
119808129  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119821387  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
119810497  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119820589  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
119821824  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119824561  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119804752  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119807117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
119818750  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119809813  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119824069  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119822805  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119818361  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
119806473  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
119814908  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119803617  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119801085  ATP synthase subunit gamma, mitochondrial [KO:K02136]
119816174  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119821561  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
119814896  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
119800757  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119807929  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119827952  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119822775  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119818833  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119812397  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
119826216  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119807061  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119817869  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
119812417  Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
119824792  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
119825399  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119813406  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119824693  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
119821107  Sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119827941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119825355  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
119819330  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
119815810  Cat; catalase [KO:K03781] [EC:1.11.1.6]
119821025  Slc26a1; sulfate anion transporter 1 [KO:K14700]
119815692  Slc26a2; sulfate transporter [KO:K14701]
119809103  Slc26a6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
119827860  Slc26a9; solute carrier family 26 member 9 [KO:K14706]
119808953  cytochrome P450 1A2-like isoform X1 [KO:K07409] [EC:1.14.14.1]
119808954  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
119808956  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
119809971  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
119820543  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
119808952  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
119807802  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
119828107  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
119827559  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
119800184  Ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
119807284  Ephx3; LOW QUALITY PROTEIN: epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
119810005  Ephx4; epoxide hydrolase 4 isoform X1 [KO:K22369] [EC:3.3.-.-]
119816882  Akr1a1; aldo-keto reductase family 1 member A1 isoform X1 [KO:K00002] [EC:1.1.1.2]
119819342  LOW QUALITY PROTEIN: aldo-keto reductase family 1 member A1-like [KO:K00002] [EC:1.1.1.2]
119817583  aldo-keto reductase family 1 member C21-like isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
119816160  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
119816243  aldo-keto reductase family 1 member C15 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
119826549  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
119827766  NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
119802181  NAD(P)H dehydrogenase [quinone] 1-like [KO:K00355] [EC:1.6.5.2]
119824712  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119824713  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119824714  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119818620  Ahr; aryl hydrocarbon receptor isoform X1 [KO:K09093]
119812543  Lpo; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
119802703  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
119802000  cytochrome b-245 light chain [KO:K08009]
119805194  Nox1; NADPH oxidase 1 [KO:K08008]
119825197  Ncf1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
119827668  Ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119803884  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
119806540  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119805132  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119820587  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119813036  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119824883  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119816694  Jun; transcription factor AP-1 [KO:K04448]
119819161  Fos; proto-oncogene c-Fos [KO:K04379]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119813044  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820620  Foxo3; forkhead box protein O3 [KO:K09408]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119814862  Ptpn1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119818958  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119827346  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
119814313  Ptprj; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
119807751  Acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
119828001  low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
119824805  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
119805816  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119805822  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119805823  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119805839  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119805847  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119805907  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119819932  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
119814345  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119818860  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
119827876  Abl2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
119820983  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
119818920  Prkd1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
119806902  Prkd3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
119823930  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119812918  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
119825970  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
119813599  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119818988  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
119801327  Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119810210  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
119818805  Nfe2l2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
119802334  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Redox toxicology of environmental chemicals causing oxidative stress.
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Related
pathway
aamp00190  Oxidative phosphorylation
aamp00980  Metabolism of xenobiotics by cytochrome P450
aamp04010  MAPK signaling pathway
aamp04064  NF-kappa B signaling pathway
aamp04066  HIF-1 signaling pathway
aamp04151  PI3K-Akt signaling pathway
aamp04370  VEGF signaling pathway
aamp05207  Chemical carcinogenesis - receptor activation
aamp05211  Renal cell carcinoma
aamp05215  Prostate cancer
aamp05219  Bladder cancer
aamp05221  Acute myeloid leukemia
aamp05222  Small cell lung cancer
aamp05223  Non-small cell lung cancer
aamp05224  Breast cancer
aamp05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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