Entry
Name
Chemical carcinogenesis - reactive oxygen species
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
ko05208 Chemical carcinogenesis - reactive oxygen species
Ortholog table
Orthology
K03942 NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2 ]
K03943 NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2 ]
K03944 NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K11352 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K03957 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K11351 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K03934 NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2 ]
K03935 NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2 ]
K03936 NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2 ]
K03937 NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938 NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939 NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940 NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2 ]
K03941 NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2 ]
K03967 NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968 NADH dehydrogenase (ubiquinone) 1 subunit C2
K00234 succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1 ]
K00235 succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1 ]
K00236 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237 succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411 ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8 ]
K00412 ubiquinol-cytochrome c reductase cytochrome b subunit
K00413 ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414 ubiquinol-cytochrome c reductase core subunit 1
K00415 ubiquinol-cytochrome c reductase core subunit 2
K00416 ubiquinol-cytochrome c reductase subunit 6
K00417 ubiquinol-cytochrome c reductase subunit 7
K00418 ubiquinol-cytochrome c reductase subunit 8
K00419 ubiquinol-cytochrome c reductase subunit 9
K00420 ubiquinol-cytochrome c reductase subunit 10
K02262 cytochrome c oxidase subunit 3
K02261 cytochrome c oxidase subunit 2
K02263 cytochrome c oxidase subunit 4
K02264 cytochrome c oxidase subunit 5a
K02265 cytochrome c oxidase subunit 5b
K02266 cytochrome c oxidase subunit 6a
K02267 cytochrome c oxidase subunit 6b
K02268 cytochrome c oxidase subunit 6c
K02270 cytochrome c oxidase subunit 7a
K02271 cytochrome c oxidase subunit 7b
K02272 cytochrome c oxidase subunit 7c
K02273 cytochrome c oxidase subunit 8
K02132 F-type H+-transporting ATPase subunit alpha
K02136 F-type H+-transporting ATPase subunit gamma
K02134 F-type H+-transporting ATPase subunit delta
K02135 F-type H+-transporting ATPase subunit epsilon
K02126 F-type H+-transporting ATPase subunit a
K02127 F-type H+-transporting ATPase subunit b
K02128 F-type H+-transporting ATPase subunit c
K02138 F-type H+-transporting ATPase subunit d
K02137 F-type H+-transporting ATPase subunit O
K02131 F-type H+-transporting ATPase subunit 6
K02125 F-type H+-transporting ATPase subunit 8
K05862 voltage-dependent anion channel protein 1
K15040 voltage-dependent anion channel protein 2
K15041 voltage-dependent anion channel protein 3
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K14700 solute carrier family 26 (sulfate anion transporter), member 1
K14701 solute carrier family 26 (sulfate anion transporter), member 2
K14704 solute carrier family 26 (sulfate anion transporter), member 6
K14706 solute carrier family 26 (sulfate anion transporter), member 9
K07415 cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K22369 epoxide hydrolase 4 [EC:3.3.-.-]
K09093 aryl hydrocarbon receptor
K21423 NADPH oxidase 4 [EC:1.6.3.-]
K08009 cytochrome b-245, alpha polypeptide
K08011 neutrophil cytosolic factor 1
K08010 neutrophil cytosolic factor 2
K04357 epidermal growth factor
K05460 hepatocyte growth factor
K04364 growth factor receptor-bound protein 2
K08845 A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 transcription factor AP-1
K04379 proto-oncogene protein c-fos
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K04392 Ras-related C3 botulinum toxin substrate 1
K09408 forkhead box protein O3
K02158 Bcl-2-antagonist of cell death
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NF-kappa-B inhibitor alpha
K04735 transcription factor p65
K02580 nuclear factor NF-kappa-B p105 subunit
K07293 tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K08268 hypoxia-inducible factor 1 alpha
K09097 aryl hydrocarbon receptor nuclear translocator
K05448 vascular endothelial growth factor A
K05638 nuclear factor erythroid 2-related factor 2
Compound
C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C03434 Tetrachlorohydroquinone
C03622 N-Hydroxy-4-aminobiphenyl
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C07557 2,3,7,8-Tetrachlorodibenzodioxin
C14209 4-Hydroxy-17beta-estradiol
C14850 Benzo[a]pyrene-7,8-oxide
C14852 Benzo[a]pyrene-7,8-dihydrodiol
C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C18205 2,2',4,4'-Tetrabromodiphenyl ether
C22355 Benzo[a]pyrene-7,8-diol
C22356 Benzo[a]pyrene-7,8-dione
C22357 17beta-Estradiol-2,3-quinone
C22381 Reactive oxygen species
Reference
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Title
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Journal
Reference
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Title
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Title
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Related pathway
ko00980 Metabolism of xenobiotics by cytochrome P450
ko04064 NF-kappa B signaling pathway
ko05207 Chemical carcinogenesis - receptor activation
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