KEGG   PATHWAY: aamp05415
Entry
aamp05415                   Pathway                                
Name
Diabetic cardiomyopathy - Arvicola amphibius (Eurasian water vole)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
aamp05415  Diabetic cardiomyopathy
aamp05415

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119816753  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
119812189  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
119812571  Gfpt2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
119806840  Gfpt1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
119800462  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119800784  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
119808786  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119814221  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
119821433  Tnni3; troponin I, cardiac muscle [KO:K12044]
119817089  Ryr2; ryanodine receptor 2 [KO:K04962]
119820485  Pln; cardiac phospholamban [KO:K05852]
119824551  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119826284  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119813074  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119823260  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
119801880  Agt; angiotensinogen isoform X1 [KO:K09821]
119828011  Ren; renin [KO:K01380] [EC:3.4.23.15]
119800259  mast cell protease 4-like [KO:K01329] [EC:3.4.21.39]
119800347  chymase-like [KO:K01329] [EC:3.4.21.39]
119800240  mast cell protease 4-like [KO:K01329] [EC:3.4.21.39]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119822474  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
119805427  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
119825197  Ncf1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
119802000  cytochrome b-245 light chain [KO:K08009]
119827668  Ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
119824015  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119822752  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119817416  type-1A angiotensin II receptor [KO:K04166]
119826658  Agtr1; type-1 angiotensin II receptor [KO:K04166]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119802075  Mmp2; 72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
119815014  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
119807796  Col1a2; collagen alpha-2(I) chain [KO:K06236]
119811687  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
119803905  Col3a1; collagen alpha-1(III) chain [KO:K19720]
119821456  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
119827432  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
119819138  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119803986  Cd36; platelet glycoprotein 4 [KO:K06259]
119822872  Ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
119822804  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
119805279  Pdk3; pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
119812531  Pdk2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
119806697  Pdk4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119827346  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
119819026  Ptpa; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
119801984  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119804974  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
119825387  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119807529  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119802120  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
119816609  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
119817978  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
119805421  Ins; insulin [KO:K04526]
119825604  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119820738  Irs1; insulin receptor substrate 1 [KO:K16172]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119808488  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
119802804  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
119800356  Tbc1d4; TBC1 domain family member 4 isoform X1 [KO:K17902]
119806976  Mpc1l; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
119820663  Mpc1; mitochondrial pyruvate carrier 1 [KO:K22138]
119827844  Mpc2; mitochondrial pyruvate carrier 2 [KO:K22139]
119817593  mitochondrial pyruvate carrier 2-like [KO:K22139]
119801461  Pdha2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
119804661  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
119827042  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
119815378  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119821089  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119823492  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119804764  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119814379  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119808469  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
119821547  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119822367  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119816292  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119817139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119800371  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119808111  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119803343  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119813558  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119807886  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119810302  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
119822816  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119815606  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119825491  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
119819937  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119807526  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119821505  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
119810151  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
119827973  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
119808788  acyl carrier protein, mitochondrial-like [KO:K03955]
119812443  acyl carrier protein, mitochondrial-like [KO:K03955]
119807454  acyl carrier protein, mitochondrial [KO:K03955]
119810775  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119811058  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
119803407  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119813692  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119818574  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
119800598  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
119806913  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
119804078  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119825606  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119825940  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
119825963  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
119801780  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119811753  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
119823332  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119812927  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119804641  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119804932  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119820696  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119827486  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119814166  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119810090  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119809107  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119803219  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810541  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119816982  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119818379  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119825922  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810417  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119821308  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119814511  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119826441  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119802653  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
119809157  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119816786  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119827624  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
119809004  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119816634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119822897  cytochrome c1, heme protein, mitochondrial [KO:K00413]
119810716  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
119818376  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119817782  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119823100  cytochrome b-c1 complex subunit 7 [KO:K00417]
119826150  cytochrome b-c1 complex subunit 7 [KO:K00417]
119812643  cytochrome b-c1 complex subunit 8 [KO:K00418]
119822943  cytochrome b-c1 complex subunit 10 [KO:K00420]
119824516  cytochrome b-c1 complex subunit 10-like [KO:K00420]
119801810  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119815669  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119808969  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119820956  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119800700  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119823348  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119824540  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119813186  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119826874  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119821317  cytochrome c oxidase subunit 6B2 [KO:K02267]
119803616  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119812348  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119820632  cytochrome c oxidase subunit 6B1 [KO:K02267]
119823502  cytochrome c oxidase subunit 6C-2 [KO:K02268]
119804134  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
119808129  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119821387  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
119810497  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119820589  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
119821824  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119824561  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119804752  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119807117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
119818750  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119809813  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119824069  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119822805  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119818361  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
119806473  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
119814908  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119803617  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119801085  ATP synthase subunit gamma, mitochondrial [KO:K02136]
119816174  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119821561  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
119814896  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
119800757  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119807929  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119827952  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119822775  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119818833  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119812397  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
119826216  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119807061  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119817869  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
119812417  Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
119824792  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
119825399  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119813406  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119824693  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119827941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119820784  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119807052  Nos3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
119814898  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119815417  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119807305  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific-like [KO:K00134] [EC:1.2.1.12]
119809429  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119809155  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119815493  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119809687  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119816981  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119823438  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
119823565  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
119804638  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119804679  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119805300  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119805853  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119812736  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826241  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826248  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119826257  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119806583  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
119800152  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119807293  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119827962  Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
119804667  G6pd; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
119812138  Gsr; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
119826264  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
119810460  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119814613  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
119809845  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
119814344  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814366  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814933  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
119824882  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119812098  angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
119812858  angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
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Reference
PMID:28231848
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Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
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Diagnostic approaches for diabetic cardiomyopathy.
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Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
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Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
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Nat Rev Cardiol 17:585-607 (2020)
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Reference
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Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
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Int J Mol Sci 20:E2833 (2019)
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Reference
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  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
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Trends Pharmacol Sci 39:452-467 (2018)
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Reference
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  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
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Front Endocrinol (Lausanne) 8:72 (2017)
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Reference
PMID:28177068
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Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
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Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
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Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
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Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
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Reference
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  Authors
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  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
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Reference
PMID:21626163
  Authors
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  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
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Heart Fail Rev 17:325-44 (2012)
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Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
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Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
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Can J Cardiol S0828-282X(20)31115-6 (2020)
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Reference
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  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
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Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
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World J Diabetes 10:490-510 (2019)
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Diabetic cardiomyopathy.
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J Card Fail 16:971-9 (2010)
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Reference
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  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
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Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
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Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
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Diabetes 57:3297-306 (2008)
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Reference
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Role of mitochondrial dysfunction in insulin resistance.
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Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
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Mol Cell Biochem 386:233-49 (2014)
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Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
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Acta Pharmacol Sin 40:1-8 (2019)
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Reference
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  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
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J Am Coll Cardiol 47:693-700 (2006)
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Reference
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Related
pathway
aamp00010  Glycolysis / Gluconeogenesis
aamp00020  Citrate cycle (TCA cycle)
aamp00190  Oxidative phosphorylation
aamp00520  Amino sugar and nucleotide sugar metabolism
aamp03320  PPAR signaling pathway
aamp04071  Sphingolipid signaling pathway
aamp04150  mTOR signaling pathway
aamp04210  Apoptosis
aamp04260  Cardiac muscle contraction
aamp04350  TGF-beta signaling pathway
aamp04614  Renin-angiotensin system
aamp04910  Insulin signaling pathway
aamp04930  Type II diabetes mellitus
aamp04931  Insulin resistance
aamp04933  AGE-RAGE signaling pathway in diabetic complications
aamp04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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