KEGG   PATHWAY: aoce04621
Entry
aoce04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Amphiprion ocellaris (clown anemonefish)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
aoce04621  NOD-like receptor signaling pathway
aoce04621

Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111562492  si:dkey-181m9.8; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
111562703  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
111563038  [KO:K03443]
111563087  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C isoform X1 [KO:K10435]
111563123  [KO:K20909]
111563160  antxr1c; anthrax toxin receptor 1 [KO:K20909]
111563258  traf5; TNF receptor-associated factor 5 [KO:K09849]
111563285  [KO:K11220]
111564212  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
111564449  [KO:K17890]
111564487  [KO:K21356] [EC:3.6.5.-]
111564611  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
111564920  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
111565366  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111565795  antxr2a; ANTXR cell adhesion molecule 2a [KO:K20909]
111565824  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
111565847  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
111565875  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
111565947  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111565992  mfn1b; mitofusin-1b [KO:K21356] [EC:3.6.5.-]
111566069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111566134  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111566182  erbin; erbin isoform X1 [KO:K12796]
111566565  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
111566615  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
111566617  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111566670  [KO:K17065] [EC:3.6.5.5]
111566984  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111567063  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111567460  [KO:K04467] [EC:2.7.11.10]
111567489  txn; thioredoxin [KO:K03671]
111567610  sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]
111567655  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
111567677  antxr1b; anthrax toxin receptor 1 isoform X1 [KO:K20909]
111567845  [KO:K10030]
111567847  [KO:K10030]
111568017  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111568127  [KO:K04513]
111568301  nek7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
111568340  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111568465  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
111568495  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
111568701  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
111568702  [KO:K20894]
111568772  pkn2a; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
111568877  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111568922  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111568932  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
111568988  [KO:K11974] [EC:2.3.2.31]
111569514  atg5; autophagy protein 5 [KO:K08339]
111569535  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111569665  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111569671  [KO:K05858] [EC:3.1.4.11]
111569680  [KO:K05858] [EC:3.1.4.11]
111569910  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
111569939  [KO:K01363] [EC:3.4.22.1]
111570370  [KO:K11974] [EC:2.3.2.31]
111570691  txn2; LOW QUALITY PROTEIN: thioredoxin, mitochondrial [KO:K03671]
111570784  [KO:K05414]
111570786  [KO:K05414]
111571002  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111571078  [KO:K04622]
111571704  trip6; thyroid receptor-interacting protein 6 [KO:K12792]
111572260  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
111572427  stat1a; signal transducer and activator of transcription 1a isoform X4 [KO:K11220]
111572700  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111573332  [KO:K21421] [EC:1.-.-.-]
111573802  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
111573807  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
111573843  [KO:K04513]
111573969  [KO:K04570]
111574080  card9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
111574785  [KO:K15040]
111574819  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
111575102  [KO:K04958]
111575123  [KO:K06630]
111575173  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
111575545  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
111575580  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111575581  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
111575648  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111575755  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
111576101  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
111576256  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
111576450  traf3; TNF receptor-associated factor 3 [KO:K03174]
111576719  nampt2; nicotinamide phosphoribosyltransferase 2 [KO:K03462] [EC:2.4.2.12]
111576738  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111577161  [KO:K08009]
111577201  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
111577290  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111577292  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111577431  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111577436  antxr1d; anthrax toxin receptor 1 [KO:K20909]
111577530  jun; transcription factor AP-1 isoform X1 [KO:K04448]
111577551  [KO:K04734]
111577584  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111577975  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
111578016  pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
111578164  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111578326  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111578651  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111578827  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
111579085  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
111579809  antxr1a; anthrax toxin receptor 1 [KO:K20909]
111579931  [KO:K02161]
111580152  [KO:K03173] [EC:2.3.2.27]
111580159  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a [KO:K12804]
111580213  [KO:K10030]
111580357  [KO:K04513]
111580399  [KO:K04519]
111580650  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
111580690  [KO:K04513]
111580849  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
111581271  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111581300  [KO:K03443]
111581320  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
111581409  [KO:K04467] [EC:2.7.11.10]
111581478  [KO:K08846] [EC:2.7.11.1]
111581711  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
111582004  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
111582017  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111582047  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111582355  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111582467  [KO:K01370] [EC:3.4.22.36]
111582710  rela; transcription factor p65 isoform X1 [KO:K04735]
111583181  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111583331  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
111583379  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
111583532  fadd; protein FADD [KO:K02373]
111583696  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
111583748  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111583887  [KO:K04519]
111584314  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111584372  irf7; interferon regulatory factor 7 [KO:K09447]
111584474  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111584600  irf3; interferon regulatory factor 3 isoform X2 [KO:K05411]
111584665  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
111585284  txnipa; thioredoxin interacting protein a [KO:K20910]
111585529  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
111586358  [KO:K05858] [EC:3.1.4.11]
111586360  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
111586917  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
111587054  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
111587194  casr; LOW QUALITY PROTEIN: extracellular calcium-sensing receptor [KO:K04612]
111587485  [KO:K04513]
111587590  [KO:K12804]
111587627  [KO:K04448]
111587713  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
111587724  [KO:K10030]
111587875  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
111588050  [KO:K20910]
111588085  sugt1; protein SGT1 homolog isoform X3 [KO:K12795]
111588089  [KO:K04398] [EC:3.4.22.61]
111588095  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111588107  [KO:K04398] [EC:3.4.22.61]
111588283  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
111588422  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
111588460  [KO:K05131]
111588622  [KO:K05131]
111588684  [KO:K02161]
111589113  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
111589175  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118469251  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
129347225  [KO:K11974] [EC:2.3.2.31]
129348076  [KO:K03671]
129348539  [KO:K08341]
129349380  [KO:K17890]
129349650  atg12; ubiquitin-like protein ATG12 [KO:K08336]
129349790  [KO:K21356] [EC:3.6.5.-]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
aoce04010  MAPK signaling pathway
aoce04140  Autophagy - animal
aoce04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

DBGET integrated database retrieval system