KEGG   PATHWAY: aoce04621
Entry
aoce04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Amphiprion ocellaris (clown anemonefish)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
aoce04621  NOD-like receptor signaling pathway
aoce04621

Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111588422  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
111581478  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
111582017  optineurin-like isoform X1 [KO:K07210]
111581409  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
111567460  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
111577292  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111581711  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111577551  NF-kappa-B inhibitor alpha-like [KO:K04734]
111583748  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111582710  transcription factor p65-like isoform X1 [KO:K04735]
111583887  interleukin-1 beta-like isoform X1 [KO:K04519]
111580399  interleukin-1 beta-like [KO:K04519]
111573783  interleukin-6-like [KO:K05405]
111579085  tumor necrosis factor-like [KO:K03156]
111575173  tumor necrosis factor-like [KO:K03156]
111567845  interleukin-8-like [KO:K10030]
111567847  interleukin-8-like [KO:K10030]
111580213  interleukin-8-like [KO:K10030]
111587724  platelet factor 4-like [KO:K10030]
111572260  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
111566069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111577584  syngr1; synaptogyrin-1 isoform X1 [KO:K04403]
111578164  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111568495  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
111565366  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111578326  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111575648  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111577431  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111569535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111582355  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111586917  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111565824  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111565847  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
111587875  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111572700  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111566984  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111589175  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111587627  jun; transcription factor AP-1 [KO:K04448]
111577530  transcription factor AP-1-like isoform X1 [KO:K04448]
111564449  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
111569514  atg5; autophagy protein 5 [KO:K08339]
111563132  atg12; ubiquitin-like protein ATG12 [KO:K08336]
111577201  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
111568877  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111568932  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
111563087  autophagy-related protein 8-like isoform X1 [KO:K10435]
111568400  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111568922  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111587054  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
111588085  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
111568702  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
111587713  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
111576256  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
111562492  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
111570370  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
111568988  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
111583181  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111571704  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
111566182  erbin; erbin isoform X1 [KO:K12796]
111580650  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
111584314  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111568017  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111580152  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111576861  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111563258  TNF receptor-associated factor 5-like [KO:K09849]
111571002  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111574080  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
111582004  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
111583331  mucin-2-like [KO:K12648]
111576450  traf3; TNF receptor-associated factor 3 [KO:K03174]
111576738  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111566565  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111575755  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
111584600  interferon regulatory factor 3-like [KO:K05411]
111584372  irf7; interferon regulatory factor 7 [KO:K09447]
111570784  interferon a3-like [KO:K05414]
111570786  interferon a3-like [KO:K05414]
111565875  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
111563123  anthrax toxin receptor 2-like [KO:K20909]
111563160  anthrax toxin receptor 1-like [KO:K20909]
111565795  antxr2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
111579809  antxr1; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
111567677  anthrax toxin receptor 1-like [KO:K20909]
111577436  anthrax toxin receptor 1-like [KO:K20909]
111578016  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111582467  caspase-1-like [KO:K01370] [EC:3.4.22.36]
111579931  apoptosis regulator Bcl-2-like [KO:K02161]
111588684  apoptosis regulator Bcl-2-like [KO:K02161]
111575580  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111573969  bcl-2-like protein 1 [KO:K04570]
111589113  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111563038  pannexin-1-like [KO:K03443]
111581300  panx1; pannexin-1 [KO:K03443]
111584009  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
111575581  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
111568465  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
111587194  casr; extracellular calcium-sensing receptor [KO:K04612]
111572598  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
111571078  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
111586358  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
111569671  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111569680  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111577975  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
111581271  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
111569665  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
111575102  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111568340  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111566134  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111575545  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
111574785  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
111577290  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111583379  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111576101  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
111564920  dhx33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
111565992  mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
111564487  mitofusin-2-like [KO:K21356] [EC:3.6.5.-]
111588283  mitofusin-2-like [KO:K06030] [EC:3.6.5.-]
111568701  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
111585529  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
111578651  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111566670  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111567063  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111576719  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
111578827  nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
111573332  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
111577161  cytochrome b-245 light chain [KO:K08009]
111588050  thioredoxin-interacting protein-like [KO:K20910]
111585284  txnip; thioredoxin-interacting protein [KO:K20910]
111567489  txn; thioredoxin [KO:K03671]
111570691  txn2; thioredoxin, mitochondrial [KO:K03671]
111568301  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
111581320  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
111564611  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
111573802  heat shock protein HSP 90-alpha 1 [KO:K04079]
111573807  heat shock protein HSP 90-alpha [KO:K04079]
111587590  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
111580159  pstpip1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
111588089  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111588095  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111588107  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111586360  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111583532  fadd; FAS-associated death domain protein [KO:K02373]
111566615  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111583696  TP53-binding protein 1-like isoform X1 [KO:K20915]
111573843  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111580849  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111587485  rho-related GTP-binding protein RhoA-C [KO:K04513]
111568127  rho-related GTP-binding protein RhoA-B [KO:K04513]
111580690  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
111584665  serine/threonine-protein kinase N1-like [KO:K06071] [EC:2.7.11.13]
111564212  pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
111568772  pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
111562703  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
111575123  14-3-3 protein epsilon [KO:K06630]
111588622  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
111588460  interferon alpha/beta receptor 2-like [KO:K05131]
111582047  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111574819  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
111572427  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111563285  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111566617  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
111576216  interferon regulatory factor 8-like isoform X1 [KO:K04693]
111567655  TIR domain-containing adapter molecule 1-like [KO:K05842]
111565947  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111569910  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
111567610  tmem173; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
aoce04010  MAPK signaling pathway
aoce04140  Autophagy - animal
aoce04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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