KEGG   PATHWAY: apri05168
Entry
apri05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Ahaetulla prasina (Asian vine snake)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
apri05168  Herpes simplex virus 1 infection
apri05168

Organism
Ahaetulla prasina (Asian vine snake) [GN:apri]
Gene
131192017  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
131187047  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
131189602  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
131190217  TNF receptor-associated factor 1-like [KO:K03173] [EC:2.3.2.27]
131186030  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
131189261  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
131203844  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
131199180  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
131191305  IKBKG; NF-kappa-B essential modulator [KO:K07210]
131187726  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
131202857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
131186557  RELA; transcription factor p65 [KO:K04735]
131199195  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
131204100  nectin-1-like isoform X1 [KO:K06081]
131204421  NECTIN2; nectin-2 isoform X1 [KO:K06531]
131185622  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
131186981  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
131191750  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
131197707  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
131196195  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
131191178  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
131186169  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
131196585  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
131197474  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131192086  complement C3-like [KO:K03990]
131192129  A.superbus venom factor 1 [KO:K03990]
131186210  C5; complement C5 [KO:K03994]
131191640  CFP; properdin [KO:K15412]
131203177  TLR2; toll-like receptor 2 [KO:K10159]
131197807  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
131184969  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
131203547  TLR3; toll-like receptor 3 [KO:K05401]
131188367  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
131201839  IRAK4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
131191609  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
131187423  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
131202222  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
131191591  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
131203631  IL1B; interleukin-1 beta [KO:K04519]
131188920  C-C motif chemokine 5-like [KO:K12499]
131197508  IL6; interleukin-6 [KO:K05405]
131189607  tumor necrosis factor-like [KO:K03156]
131191152  interleukin-12 subunit beta-like [KO:K05425]
131190142  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
131202555  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
131187938  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
131201940  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
131190689  interferon kappa-like [KO:K05414]
131190690  interferon kappa-like [KO:K05414]
131190691  interferon tau-2-like [KO:K05414]
131190692  interferon omega-1-like [KO:K05414]
131190693  interferon omega-1-like [KO:K05414]
131190694  interferon omega-1-like [KO:K05414]
131190695  interferon alpha-21-like [KO:K05414]
131185560  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
131187764  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
131185237  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
131188848  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
131197308  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
131187656  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
131187504  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
131185690  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
131187769  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
131194105  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
131188948  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
131200776  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
131196227  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
131190270  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
131201670  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
131203998  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
131204791  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
131199275  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
131199527  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
131199577  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
131196793  suppressor of cytokine signaling 3-like [KO:K04696]
131193206  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
131195208  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
131190997  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
131201014  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
131191430  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
131196885  IRF9; interferon regulatory factor 9 [KO:K04693]
131189491  zinc finger protein 160-like [KO:K09228]
131189497  zinc finger protein 260-like [KO:K09228]
131189499  zinc finger protein 239-like [KO:K09228]
131189500  zinc finger protein 420-like [KO:K09228]
131189507  zinc finger protein 665-like [KO:K09228]
131189508  zinc finger protein 501-like [KO:K09228]
131189509  zinc finger protein 239-like [KO:K09228]
131189519  zinc finger protein 585A-like [KO:K09228]
131189527  zinc finger protein ZFP2-like [KO:K09228]
131189542  zinc finger protein 14-like [KO:K09228]
131189551  zinc finger protein 429-like [KO:K09228]
131189600  zinc finger protein 271-like [KO:K09228]
131189614  zinc finger protein 84-like [KO:K09228]
131189640  zinc finger protein 84-like [KO:K09228]
131189648  zinc finger protein OZF-like [KO:K09228]
131189656  zinc finger protein 420-like [KO:K09228]
131189834  zinc finger protein 665-like [KO:K09228]
131189836  zinc finger protein 665-like [KO:K09228]
131189837  zinc finger protein 260-like isoform X1 [KO:K09228]
131189841  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
131189842  zinc finger protein 660-like isoform X1 [KO:K09228]
131190281  zinc finger protein 189-like isoform X1 [KO:K09228]
131190289  zinc finger protein 492-like [KO:K09228]
131190303  zinc finger protein 501-like [KO:K09228]
131190309  zinc finger protein 239-like [KO:K09228]
131190316  zinc finger protein 420-like [KO:K09228]
131190349  zinc finger protein 345-like [KO:K09228]
131190352  zinc finger protein 850-like [KO:K09228]
131190355  zinc finger protein OZF-like [KO:K09228]
131190356  zinc finger protein 271-like [KO:K09228]
131190371  zinc finger protein 585A-like [KO:K09228]
131190436  zinc finger protein 419-like [KO:K09228]
131190439  zinc finger protein 664-like [KO:K09228]
131190456  zinc finger protein 678-like [KO:K09228]
131190464  zinc finger protein 436-like [KO:K09228]
131190465  LOW QUALITY PROTEIN: zinc finger protein 91-like [KO:K09228]
131190476  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
131190477  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
131196509  zinc finger protein 777-like isoform X1 [KO:K09228]
131196516  zinc finger protein 398-like isoform X1 [KO:K09228]
131196521  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
131190983  zinc finger protein 84-like [KO:K09228]
131191193  zinc finger protein 271-like isoform X1 [KO:K09228]
131191227  zinc finger protein 883-like isoform X1 [KO:K09228]
131191235  zinc finger protein 239-like [KO:K09228]
131197167  zinc finger protein 594-like [KO:K09228]
131185505  zinc finger protein 84-like isoform X1 [KO:K09228]
131191486  zinc finger protein 726-like [KO:K09228]
131186026  zinc finger protein 664-like [KO:K09228]
131191771  zinc finger protein 493-like [KO:K09228]
131191774  zinc finger protein 436-like isoform X1 [KO:K09228]
131191775  zinc finger protein 420-like isoform X1 [KO:K09228]
131191778  zinc finger protein 436-like isoform X1 [KO:K09228]
131191779  zinc finger protein 883-like isoform X1 [KO:K09228]
131191789  zinc finger protein 585A-like [KO:K09228]
131191790  zinc finger protein 585A-like [KO:K09228]
131191913  zinc finger protein 708-like isoform X1 [KO:K09228]
131191914  zinc finger protein 850-like [KO:K09228]
131191915  zinc finger protein 260-like isoform X1 [KO:K09228]
131191916  zinc finger protein 260-like [KO:K09228]
131191919  zinc finger protein 260-like [KO:K09228]
131191922  zinc finger protein 420-like [KO:K09228]
131191924  zinc finger protein OZF-like [KO:K09228]
131191925  zinc finger protein 501-like [KO:K09228]
131191926  gastrula zinc finger protein XlCGF17.1-like isoform X1 [KO:K09228]
131191927  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
131197704  zinc finger protein 282-like [KO:K09228]
131186200  zinc finger protein OZF-like [KO:K09228]
131186201  gastrula zinc finger protein XlCGF52.1-like isoform X1 [KO:K09228]
131186224  zinc finger protein 345-like [KO:K09228]
131186225  zinc finger protein 345-like [KO:K09228]
131186286  zinc finger protein 91-like [KO:K09228]
131186291  zinc finger protein 665-like [KO:K09228]
131186293  zinc finger protein 883-like isoform X1 [KO:K09228]
131186295  zinc finger protein 665-like [KO:K09228]
131186296  zinc finger protein 501-like [KO:K09228]
131186298  zinc finger protein 226-like [KO:K09228]
131186300  zinc finger protein with KRAB and SCAN domains 1-like [KO:K09228]
131192028  zinc finger protein 493-like isoform X1 [KO:K09228]
131192030  zinc finger protein 345-like [KO:K09228]
131192031  zinc finger protein 883-like isoform X1 [KO:K09228]
131192033  zinc finger protein ZFP2-like isoform X1 [KO:K09228]
131192037  zinc finger protein 850-like [KO:K09228]
131192043  zinc finger protein 287-like [KO:K09228]
131198078  zinc finger protein 271-like [KO:K09228]
131198289  uncharacterized protein LOC131198289 [KO:K09228]
131186509  uncharacterized protein LOC131186509 [KO:K09228]
131192480  zinc finger protein 271-like isoform X1 [KO:K09228]
131192482  zinc finger protein 268-like [KO:K09228]
131192487  zinc finger protein 420-like [KO:K09228]
131192503  zinc finger protein 239-like [KO:K09228]
131192519  zinc finger protein 850-like [KO:K09228]
131192520  zinc finger protein 420-like [KO:K09228]
131192521  zinc finger protein 850-like [KO:K09228]
131192524  zinc finger protein 883-like [KO:K09228]
131192543  zinc finger protein 383-like isoform X1 [KO:K09228]
131192647  zinc finger protein 420-like isoform X1 [KO:K09228]
131192649  zinc finger protein 420-like isoform X1 [KO:K09228]
131192653  zinc finger protein 585A-like isoform X1 [KO:K09228]
131192654  zinc finger protein 585B-like isoform X1 [KO:K09228]
131192655  zinc finger protein 420-like [KO:K09228]
131192658  zinc finger protein 493-like [KO:K09228]
131192661  zinc finger protein 493-like isoform X1 [KO:K09228]
131192663  zinc finger protein 850-like [KO:K09228]
131192668  putative zinc finger protein 66 [KO:K09228]
131192673  zinc finger protein 665-like [KO:K09228]
131192674  zinc finger protein 665-like isoform X1 [KO:K09228]
131192676  zinc finger protein 708-like [KO:K09228]
131192677  zinc finger protein 85-like [KO:K09228]
131192679  zinc finger protein 708-like [KO:K09228]
131192680  zinc finger protein 708-like isoform X1 [KO:K09228]
131192681  zinc finger protein 493-like isoform X1 [KO:K09228]
131192682  zinc finger protein 345-like isoform X1 [KO:K09228]
131192686  zinc finger protein 260-like [KO:K09228]
131192688  zinc finger protein 260-like [KO:K09228]
131192692  zinc finger protein 665-like isoform X1 [KO:K09228]
131192696  zinc finger protein ZFP2-like [KO:K09228]
131192697  zinc finger protein 723-like [KO:K09228]
131192698  zinc finger protein 665-like isoform X1 [KO:K09228]
131192704  zinc finger protein 883-like [KO:K09228]
131192707  zinc finger protein 345-like [KO:K09228]
131192711  zinc finger protein 883-like isoform X1 [KO:K09228]
131192712  zinc finger protein 737-like isoform X1 [KO:K09228]
131192715  zinc finger protein 260-like [KO:K09228]
131192716  zinc finger protein 260-like [KO:K09228]
131192720  zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
131192726  zinc finger protein 160-like isoform X1 [KO:K09228]
131192727  zinc finger protein 260-like [KO:K09228]
131192730  zinc finger protein 883-like [KO:K09228]
131192732  zinc finger protein 1 homolog [KO:K09228]
131192734  zinc finger protein 845-like isoform X1 [KO:K09228]
131192735  zinc finger protein 260-like isoform X1 [KO:K09228]
131192740  zinc finger protein 506-like [KO:K09228]
131192746  zinc finger protein 3-like isoform X1 [KO:K09228]
131192751  zinc finger protein 85-like isoform X1 [KO:K09228]
131192754  zinc finger protein with KRAB and SCAN domains 7-like [KO:K09228]
131192756  zinc finger protein 501-like isoform X1 [KO:K09228]
131192760  zinc finger protein 501-like [KO:K09228]
131192764  zinc finger protein OZF-like [KO:K09228]
131192769  zinc finger protein 665-like [KO:K09228]
131192770  zinc finger protein OZF-like [KO:K09228]
131192771  zinc finger protein OZF-like [KO:K09228]
131192772  zinc finger protein OZF-like [KO:K09228]
131192773  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
131192775  zinc finger protein OZF-like [KO:K09228]
131192776  zinc finger protein OZF-like [KO:K09228]
131192779  zinc finger protein OZF-like [KO:K09228]
131192780  zinc finger protein OZF-like [KO:K09228]
131192781  zinc finger protein OZF-like [KO:K09228]
131192786  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
131192791  zinc finger protein 239-like isoform X1 [KO:K09228]
131192798  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
131192836  LOW QUALITY PROTEIN: zinc finger protein 91-like [KO:K09228]
131192839  LOW QUALITY PROTEIN: zinc finger protein 91-like [KO:K09228]
131192840  zinc finger protein 493-like [KO:K09228]
131192843  zinc finger protein 420-like [KO:K09228]
131192845  zinc finger protein 493-like [KO:K09228]
131192846  zinc finger protein 43-like [KO:K09228]
131187321  zinc finger protein 436-like [KO:K09228]
131193100  zinc finger protein 850-like isoform X1 [KO:K09228]
131193102  zinc finger protein 850-like isoform X1 [KO:K09228]
131193104  zinc finger protein 883-like [KO:K09228]
131193105  zinc finger protein 268-like isoform X1 [KO:K09228]
131193109  zinc finger protein 268-like [KO:K09228]
131193110  zinc finger protein 268-like [KO:K09228]
131193112  zinc finger protein 268-like [KO:K09228]
131193113  zinc finger protein 268-like [KO:K09228]
131193114  zinc finger protein 268-like [KO:K09228]
131193115  zinc finger protein OZF-like [KO:K09228]
131193117  zinc finger protein 271-like [KO:K09228]
131193118  zinc finger protein 84-like [KO:K09228]
131193119  zinc finger protein OZF-like [KO:K09228]
131193120  zinc finger protein 271-like [KO:K09228]
131193122  zinc finger protein 84-like [KO:K09228]
131193124  zinc finger protein 252-like [KO:K09228]
131193126  zinc finger protein 135-like [KO:K09228]
131193130  zinc finger protein 135-like isoform X1 [KO:K09228]
131193136  zinc finger protein 850-like [KO:K09228]
131193138  zinc finger protein 208-like [KO:K09228]
131193251  zinc finger protein 3-like [KO:K09228]
131193415  zinc finger protein 665-like isoform X1 [KO:K09228]
131193416  zinc finger protein 493-like isoform X1 [KO:K09228]
131193418  zinc finger protein 493-like isoform X1 [KO:K09228]
131193419  zinc finger protein 420-like [KO:K09228]
131193420  zinc finger protein 595-like isoform X1 [KO:K09228]
131193424  zinc finger protein 420-like isoform X1 [KO:K09228]
131193434  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
131193440  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
131193441  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
131193460  zinc finger protein 850-like [KO:K09228]
131193461  zinc finger protein 850-like [KO:K09228]
131193466  zinc finger protein 850-like [KO:K09228]
131193471  zinc finger protein 850-like isoform X1 [KO:K09228]
131193472  zinc finger protein 383-like isoform X1 [KO:K09228]
131193475  zinc finger protein 268-like [KO:K09228]
131193476  zinc finger protein 252-like [KO:K09228]
131193480  zinc finger protein OZF-like [KO:K09228]
131193483  zinc finger protein 420-like [KO:K09228]
131193484  zinc finger protein 84-like [KO:K09228]
131193487  zinc finger protein 271-like [KO:K09228]
131193488  zinc finger protein 501-like isoform X1 [KO:K09228]
131193489  zinc finger protein 84-like [KO:K09228]
131193490  zinc finger protein 271-like [KO:K09228]
131193491  zinc finger protein 271-like [KO:K09228]
131193492  zinc finger protein 658B-like [KO:K09228]
131193493  zinc finger protein OZF-like [KO:K09228]
131193494  zinc finger protein 84-like [KO:K09228]
131193495  zinc finger protein 271-like [KO:K09228]
131193496  zinc finger protein OZF-like [KO:K09228]
131193503  zinc finger protein 84-like [KO:K09228]
131193518  zinc finger protein 208-like [KO:K09228]
131193519  zinc finger protein 208-like [KO:K09228]
131193521  zinc finger protein 850-like [KO:K09228]
131193522  zinc finger protein 850-like [KO:K09228]
131193523  zinc finger protein 208-like [KO:K09228]
131193525  zinc finger protein 850-like [KO:K09228]
131193528  zinc finger protein 268-like [KO:K09228]
131193529  zinc finger protein 850-like [KO:K09228]
131193530  zinc finger protein 850-like [KO:K09228]
131193532  zinc finger protein 850-like [KO:K09228]
131193534  zinc finger protein 850-like [KO:K09228]
131193535  zinc finger protein 84-like [KO:K09228]
131193537  zinc finger protein 84-like [KO:K09228]
131193563  zinc finger protein 493-like [KO:K09228]
131193596  zinc finger protein 84-like [KO:K09228]
131193610  ZNF3; zinc finger protein 3 [KO:K09228]
131193670  zinc finger protein 665-like [KO:K09228]
131193698  zinc finger protein 436-like [KO:K09228]
131193711  zinc finger protein 420-like [KO:K09228]
131188495  uncharacterized protein LOC131188495 [KO:K09228]
131190377  zinc finger protein 850-like [KO:K09228]
131192660  zinc finger protein 271-like isoform X1 [KO:K09228]
131202531  IFNG; interferon gamma [KO:K04687]
131192114  IFNGR1; interferon gamma receptor 1 [KO:K05132]
131199419  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
131189824  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
131192718  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
131184528  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
131184820  PML; protein PML [KO:K10054] [EC:2.3.2.-]
131191900  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
131191777  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
131192761  tapasin-like [KO:K08058]
131184558  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
131187991  CALR3; calreticulin-3 [KO:K08057]
131193571  CALR; calreticulin [KO:K08057]
131193959  calreticulin-like [KO:K08057]
131189852  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
131189854  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
131189866  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
131184584  B2M; beta-2-microglobulin [KO:K08055]
131192802  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
131192803  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
131192806  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
131192807  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
131192809  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
131192810  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
131192811  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
131192812  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
131192813  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
131192814  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
131192816  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
131192818  class II histocompatibility antigen, M alpha chain [KO:K06752]
131192830  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
131193612  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
131192279  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
131200624  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
131200702  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131197634  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
131187034  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131196302  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
131191378  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131188166  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
131189498  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131204269  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131187974  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131186039  TSC1; hamartin isoform X1 [KO:K07206]
131185165  TSC2; tuberin isoform X1 [KO:K07207]
131198745  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
131186985  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
131203682  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
131196333  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
131188719  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
131191907  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
131194732  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
131195476  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
131204489  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
131187526  serine/arginine-rich splicing factor 5-like [KO:K12893]
131187535  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
131189150  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
131185565  SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
131186494  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
131190671  ALYREF; THO complex subunit 4 [KO:K12881]
131194640  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
131200848  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
131193455  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
131183951  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
131188800  FADD; FAS-associated death domain protein [KO:K02373]
131202018  BID; BH3-interacting domain death agonist [KO:K04726]
131197615  apoptosis regulator BAX-like isoform X1 [KO:K02159]
131198324  apoptosis regulator BAX-like [KO:K02159]
131194729  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
131186774  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
131194707  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
131194852  BCL2L1; bcl-2-like protein 1 [KO:K04570]
131201685  cytochrome c iso-1/iso-2 [KO:K08738]
131197716  cytochrome c [KO:K08738]
131202060  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
131187089  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
131202823  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
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MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
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  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
apri03040  Spliceosome
apri03050  Proteasome
apri04115  p53 signaling pathway
apri04210  Apoptosis
apri04620  Toll-like receptor signaling pathway
apri04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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