KEGG   PATHWAY: btax05020
Entry
btax05020                   Pathway                                
Name
Prion disease - Budorcas taxicolor (takin)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
btax05020  Prion disease
btax05020

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128058006  PRNP; major prion protein [KO:K05634]
128052162  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
128060977  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
128061859  LAMC1; laminin subunit gamma-1 [KO:K05635]
128045681  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
128053277  LOW QUALITY PROTEIN: stress-induced-phosphoprotein 1-like [KO:K09553]
128068510  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128064207  BAX; apoptosis regulator BAX [KO:K02159]
128053552  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
128055110  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
128071087  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
128047858  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
128065196  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
128063420  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
128052107  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
128051405  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
128055241  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
128048945  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
128052044  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
128070004  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
128061188  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128055367  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
128056196  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
128054117  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
128047885  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128048350  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
128047285  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
128063697  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
128048064  RYR2; ryanodine receptor 2 [KO:K04962]
128054439  RYR3; ryanodine receptor 3 [KO:K04963]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128068977  BAD; bcl2-associated agonist of cell death [KO:K02158]
128050636  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
128058634  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
128059118  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
128047278  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
128068182  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
128069760  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
128070620  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
128068228  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
128062431  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
128047614  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
128048021  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
128069489  cytochrome c 2 [KO:K08738]
128046227  cytochrome c [KO:K08738]
128053843  cytochrome c-like [KO:K08738]
128053924  cytochrome c [KO:K08738]
128054019  cytochrome c-like [KO:K08738]
128061241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128047393  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
8250974  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
8250973  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
8250967  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
8250969  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
8250968  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
8250970  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
8250971  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
128068660  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
128058489  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
128067418  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
128045118  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
128050721  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
128063056  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
128046973  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
128046696  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
128048621  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
128046403  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
128048517  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
128051330  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
128056168  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
128047836  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
128044635  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
128043191  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
128051437  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
128048376  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
128051389  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
128066874  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
128046972  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
128067868  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
128053787  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
128046653  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
128052403  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
128051202  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
128067819  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
128059268  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
128043200  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
128070595  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
128063561  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
128044487  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
128060120  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
128066111  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
128045154  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
128066127  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
128050799  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
128068819  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
128062454  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
128068963  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
128066232  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
128069029  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
128050328  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
128044593  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
128060079  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
128062194  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
128055900  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
128063107  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
128054757  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
8250972  CYTB; cytochrome b [KO:K00412]
128059285  cytochrome c1, heme protein, mitochondrial [KO:K00413]
128065950  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
128063714  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
128045003  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
128045475  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
128046897  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
128059229  cytochrome b-c1 complex subunit 7 [KO:K00417]
128051423  cytochrome b-c1 complex subunit 8 [KO:K00418]
8250966  COX3; cytochrome c oxidase subunit III [KO:K02262]
8250962  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
8250963  COX2; cytochrome c oxidase subunit II [KO:K02261]
128063106  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
128058730  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
128066743  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
128056132  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
128043457  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
128062396  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
128063483  cytochrome c oxidase subunit 6B1 [KO:K02267]
128063570  cytochrome c oxidase subunit 6B2 [KO:K02267]
128056188  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
128063622  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
128071326  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
128053423  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
128070083  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
128052458  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
128066651  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
128067277  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
128047302  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
128058482  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
128051117  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
8250965  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
128044778  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
128069351  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
128064942  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
128047760  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
128065156  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
128046837  ATP synthase subunit d, mitochondrial-like [KO:K02138]
128050383  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
128046026  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
8250964  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
128066636  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
128052482  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
128046548  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
128066612  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
128058120  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
128067504  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
128044931  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
128060374  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
128054123  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
128064919  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
128055496  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
128065066  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
128044644  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
128053967  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
128053279  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
128044943  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
128046248  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
128054311  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
128063053  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
128054072  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
128048576  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
128060097  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
128065090  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
128063955  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
128064393  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
128064620  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
128062298  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
128064619  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
128064726  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
128045005  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
128063343  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
128068761  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
128068797  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
128063218  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
128058741  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
128052536  C5; complement C5 [KO:K03994]
128066200  C6; complement component C6 [KO:K03995]
128065984  C7; complement component C7 [KO:K03996]
128045666  C8A; complement component C8 alpha chain [KO:K03997]
128045434  C8B; complement component C8 beta chain [KO:K03998]
128056557  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
128066230  C9; complement component C9 [KO:K04000]
128043402  C1QA; complement C1q subcomponent subunit A isoform X1 [KO:K03986]
128043404  C1QB; complement C1q subcomponent subunit B [KO:K03987]
128043405  C1QC; complement C1q subcomponent subunit C [KO:K03988]
128044370  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
128061031  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
128055080  heat shock 70 kDa protein 1A [KO:K03283]
128055295  heat shock 70 kDa protein 1-like [KO:K03283]
128056106  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
128046440  CAV1; caveolin-1 isoform X1 [KO:K06278]
128046728  CAV2; caveolin-2 [KO:K12958]
128046664  CAV3; caveolin-3 [KO:K12959]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128044536  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
128070075  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
128063662  cytochrome b-245 light chain [KO:K08009]
128048638  NCF4; neutrophil cytosol factor 4 [KO:K08012]
128062323  NCF1; neutrophil cytosol factor 1 [KO:K08011]
128061783  NCF2; neutrophil cytosol factor 2 [KO:K08010]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128071103  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128061475  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
128065610  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128044759  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
128051508  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
128052214  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
128046532  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
128060385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
128046584  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
128056429  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
128050654  EGR1; early growth response protein 1 [KO:K09203]
128064805  C-C motif chemokine 5 [KO:K12499]
128056679  IL1A; interleukin-1 alpha [KO:K04383]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128046952  IL6; interleukin-6 [KO:K05405]
128056772  TNF; tumor necrosis factor [KO:K03156]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128063252  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
128058293  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
128056158  CSNK2B; casein kinase II subunit beta [KO:K03115]
128069375  KIF5C; kinesin heavy chain [KO:K10396]
128058018  KIF5B; kinesin-1 heavy chain [KO:K10396]
128047545  KIF5A; kinesin heavy chain [KO:K10396]
128056603  KLC4; kinesin light chain 4 [KO:K10407]
128063815  KLC3; kinesin light chain 3 [KO:K10407]
128066619  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
128068956  KLC2; kinesin light chain 2 [KO:K10407]
128063978  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
128058048  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
128047715  TUBA8; tubulin alpha-8 chain [KO:K07374]
128068330  tubulin alpha-1D chain [KO:K07374]
128048810  tubulin alpha-1C chain isoform X1 [KO:K07374]
128048811  tubulin alpha-1C chain-like [KO:K07374]
128048812  tubulin alpha-1B chain [KO:K07374]
128048813  tubulin alpha-1A chain isoform X1 [KO:K07374]
128062492  tubulin alpha-3 chain [KO:K07374]
128062504  tubulin alpha-3 chain-like [KO:K07374]
128063435  tubulin beta-3 chain [KO:K07375]
128050745  TUBB4A; tubulin beta-4A chain [KO:K07375]
128058492  TUBB1; tubulin beta-1 chain [KO:K07375]
128067310  TUBB6; tubulin beta-6 chain [KO:K07375]
128055095  TUBB; tubulin beta chain [KO:K07375]
128055224  TUBB4B; tubulin beta-4B chain [KO:K07375]
128055993  tubulin beta-2A chain isoform X1 [KO:K07375]
128055999  tubulin beta-2B chain-like [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
DOI:10.1017/erm.2016.8
Reference
PMID:25584786
  Authors
Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
  Journal
Mol Cell Neurosci 66:12-20 (2015)
DOI:10.1016/j.mcn.2014.12.009
Reference
PMID:20889378
  Authors
Soto C, Satani N
  Title
The intricate mechanisms of neurodegeneration in prion diseases.
  Journal
Trends Mol Med 17:14-24 (2011)
DOI:10.1016/j.molmed.2010.09.001
Reference
PMID:27060771
  Authors
Mays CE, Soto C
  Title
The stress of prion disease.
  Journal
Brain Res 1648:553-560 (2016)
DOI:10.1016/j.brainres.2016.04.009
Reference
PMID:32565065
  Authors
Jones E, Mead S
  Title
Genetic risk factors for Creutzfeldt-Jakob disease.
  Journal
Neurobiol Dis 142:104973 (2020)
DOI:10.1016/j.nbd.2020.104973
Reference
PMID:18245809
  Authors
Kovacs GG, Budka H
  Title
Prion diseases: from protein to cell pathology.
  Journal
Am J Pathol 172:555-65 (2008)
DOI:10.2353/ajpath.2008.070442
Reference
PMID:15695097
  Authors
Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
  Journal
Trends Cell Biol 15:102-11 (2005)
DOI:10.1016/j.tcb.2004.12.002
Reference
PMID:17051207
  Authors
Caughey B, Baron GS
  Title
Prions and their partners in crime.
  Journal
Nature 443:803-10 (2006)
DOI:10.1038/nature05294
Reference
PMID:11592845
  Authors
Chiesa R, Harris DA
  Title
Prion diseases: what is the neurotoxic molecule?
  Journal
Neurobiol Dis 8:743-63 (2001)
DOI:10.1006/nbdi.2001.0433
Reference
PMID:17085779
  Authors
Fasano C, Campana V, Zurzolo C
  Title
Prions: protein only or something more? Overview of potential prion cofactors.
  Journal
J Mol Neurosci 29:195-214 (2006)
DOI:10.1385/JMN:29:3:195
Reference
PMID:14705136
  Authors
Roucou X, Gains M, LeBlanc AC
  Title
Neuroprotective functions of prion protein.
  Journal
J Neurosci Res 75:153-61 (2004)
DOI:10.1002/jnr.10864
Reference
PMID:10398674
  Authors
Harris DA
  Title
Cellular biology of prion diseases.
  Journal
Clin Microbiol Rev 12:429-44 (1999)
Reference
PMID:15890824
  Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
  Title
Prion biology relevant to bovine spongiform encephalopathy.
  Journal
J Anim Sci 83:1455-76 (2005)
DOI:10.2527/2005.8361455x
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
  Journal
Biochem Biophys Res Commun 483:1148-1155 (2017)
DOI:10.1016/j.bbrc.2016.07.118
Reference
PMID:31618844
  Authors
Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
Prion Protein in Glioblastoma Multiforme.
  Journal
Int J Mol Sci 20:E5107 (2019)
DOI:10.3390/ijms20205107
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:30710214
  Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
  Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
  Journal
Mol Neurobiol 56:6035-6045 (2019)
DOI:10.1007/s12035-019-1505-6
Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
  Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
DOI:10.1093/abbs/gmt014
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:29194372
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
  Journal
Pathogens 6:E63 (2017)
DOI:10.3390/pathogens6040063
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:18420416
  Authors
Ferreiro E, Oliveira CR, Pereira CM
  Title
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
  Journal
Neurobiol Dis 30:331-42 (2008)
DOI:10.1016/j.nbd.2008.02.003
Reference
PMID:16844381
  Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
  Title
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
  Journal
Neurobiol Dis 23:669-78 (2006)
DOI:10.1016/j.nbd.2006.05.011
Reference
PMID:21980554
  Authors
Torres M, Encina G, Soto C, Hetz C
  Title
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
  Journal
Commun Integr Biol 4:258-61 (2011)
DOI:10.4161/cib.4.3.15019
Reference
PMID:25766616
  Authors
Ciechanover A, Kwon YT
  Title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
  Journal
Exp Mol Med 47:e147 (2015)
DOI:10.1038/emm.2014.117
Reference
PMID:17466621
  Authors
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ
  Title
Disease-associated prion protein oligomers inhibit the 26S proteasome.
  Journal
Mol Cell 26:175-88 (2007)
DOI:10.1016/j.molcel.2007.04.001
Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
  Title
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
  Journal
Science 284:339-43 (1999)
DOI:10.1126/science.284.5412.339
Reference
PMID:14532116
  Authors
Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
  Title
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
  Journal
EMBO J 22:5435-45 (2003)
DOI:10.1093/emboj/cdg537
Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
  Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
  Journal
Front Cell Neurosci 13:350 (2019)
DOI:10.3389/fncel.2019.00350
Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
Reference
PMID:21196165
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
Reference
PMID:23479001
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
  Journal
Cell Mol Biol Lett 18:209-30 (2013)
DOI:10.2478/s11658-013-0085-0
Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
  Journal
Front Aging Neurosci 9:120 (2017)
DOI:10.3389/fnagi.2017.00120
Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
DOI:10.1074/jbc.M410966200
Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
DOI:10.1073/pnas.0408612101
Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
DOI:10.1186/1750-1326-5-6
Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
DOI:10.1007/s12035-018-1193-7
Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
btax00190  Oxidative phosphorylation
btax03050  Proteasome
btax04020  Calcium signaling pathway
btax04140  Autophagy - animal
btax04141  Protein processing in endoplasmic reticulum
btax04142  Lysosome
btax04144  Endocytosis
btax04210  Apoptosis
btax04330  Notch signaling pathway
btax04610  Complement and coagulation cascades
btax04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

DBGET integrated database retrieval system