KEGG   PATHWAY: btax04020
Entry
btax04020                   Pathway                                
Name
Calcium signaling pathway - Budorcas taxicolor (takin)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04020  Calcium signaling pathway
btax04020

Other DBs
GO: 0019722
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128043196  ORAI3; protein orai-3 [KO:K16058]
128043359  ORAI2; protein orai-2 [KO:K16057]
128043484  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
128043555  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
128043709  PTAFR; platelet-activating factor receptor [KO:K04279]
128043813  [KO:K04161]
128043941  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
128044454  MCOLN2; mucolipin-2 [KO:K04993]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128044483  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128044554  CASQ1; calsequestrin-1 [KO:K23468]
128044674  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
128044677  CASQ2; calsequestrin-2 [KO:K23445]
128044808  MCOLN3; mucolipin-3 [KO:K04994]
128045179  NGF; beta-nerve growth factor [KO:K02582]
128045516  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
128045701  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
128046225  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
128046331  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128046468  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
128046469  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128046678  HGF; hepatocyte growth factor [KO:K05460]
128046764  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128046777  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
128047068  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
128047085  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
128047278  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128047350  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
128047384  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128047393  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
128047602  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
128047614  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128047858  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
128047957  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
128048008  FGF6; fibroblast growth factor 6 [KO:K04358]
128048064  RYR2; ryanodine receptor 2 [KO:K04962]
128048297  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
128048310  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128048640  AVPR1A; vasopressin V1a receptor [KO:K04226]
128048649  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
128048681  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
128048690  TACR2; substance-K receptor [KO:K04223]
128048751  AGTR1; type-1 angiotensin II receptor [KO:K04166]
128048891  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128048945  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
128048959  FGF23; fibroblast growth factor 23 [KO:K22428]
128048997  MST1; hepatocyte growth factor-like protein [KO:K23441]
128049397  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128049477  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128049625  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
128049626  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
128049691  STIM2; stromal interaction molecule 2 [KO:K18196]
128049813  TACR3; LOW QUALITY PROTEIN: neuromedin-K receptor [KO:K04224]
128049842  CCKAR; cholecystokinin receptor type A [KO:K04194]
128049943  DRD5; D(1B) dopamine receptor [KO:K05840]
128049947  FGF5; fibroblast growth factor 5 [KO:K04358]
128049963  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128050311  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
128050317  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128050341  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
128050399  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128050561  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
128050636  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
128050674  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
128050795  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
128050845  FGF1; fibroblast growth factor 1 [KO:K18496]
128050904  ADRB2; beta-2 adrenergic receptor [KO:K04142]
128051051  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
128051297  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
128051314  TBXA2R; thromboxane A2 receptor [KO:K04264]
128051393  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
128051405  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
128051498  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128051703  FGF22; fibroblast growth factor 22 [KO:K04358]
128052044  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
128052107  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128052307  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128052310  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
128052378  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
128052409  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128052693  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
128052704  FGF17; fibroblast growth factor 17 [KO:K04358]
128053086  TRDN; triadin isoform X1 [KO:K23449]
128053357  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
128053518  OXTR; oxytocin receptor [KO:K04229]
128053757  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
128053785  FGF7; fibroblast growth factor 7 [KO:K04358]
128053854  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
128053855  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
128054050  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128054080  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
128054190  F2R; proteinase-activated receptor 1 [KO:K03914]
128054267  CALM1; calmodulin-1 [KO:K02183]
128054439  RYR3; ryanodine receptor 3 [KO:K04963]
128054467  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
128054499  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
128054518  DRD1; D(1A) dopamine receptor [KO:K04144]
128054615  HRH2; histamine H2 receptor [KO:K04150]
128054647  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
128055110  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
128055233  TFEB; transcription factor EB [KO:K15590]
128055241  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128055664  TGFA; protransforming growth factor alpha [KO:K08774]
128055817  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
128055912  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128056478  TACR1; substance-P receptor [KO:K04222]
128056500  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
128056529  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
128056684  CALM2; calmodulin-2 [KO:K02183]
128056879  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
128056971  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
128057485  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128057718  FGF9; fibroblast growth factor 9 [KO:K04358]
128057720  EDNRB; endothelin receptor type B [KO:K04198]
128057812  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
128057846  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
128058011  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128058107  [KO:K04282]
128058135  TNNC2; troponin C, skeletal muscle [KO:K12042]
128058189  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
128058230  [KO:K02183]
128058250  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
128058303  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
128058335  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128058542  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
128058634  [KO:K05862]
128058642  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
128058829  [KO:K04632]
128058874  NTSR1; neurotensin receptor type 1 [KO:K04211]
128058891  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
128059118  [KO:K15040]
128059256  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
128059420  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
128059603  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
128060722  P2RX3; P2X purinoceptor 3 [KO:K05217]
128060743  PDGFD; platelet-derived growth factor D [KO:K05450]
128060873  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
128060923  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
128061017  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
128061188  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128061226  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
128061269  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
128061462  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
128061581  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
128061593  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
128061700  AVPR1B; vasopressin V1b receptor [KO:K04227]
128061892  [KO:K05850] [EC:7.2.2.10]
128062014  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
128062068  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128062284  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
128062344  P2RX2; P2X purinoceptor 2 [KO:K05216]
128062357  EDNRA; endothelin-1 receptor [KO:K04197]
128062418  ADORA2A; adenosine receptor A2a [KO:K04266]
128062428  PDGFC; platelet-derived growth factor C [KO:K05450]
128062431  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
128062493  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
128062518  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
128062554  P2RX7; P2X purinoceptor 7 [KO:K05220]
128062606  P2RX4; P2X purinoceptor 4 [KO:K05218]
128062797  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
128062979  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128063111  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
128063135  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
128063240  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
128063396  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
128063420  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
128063423  [KO:K04282]
128063697  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
128063741  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
128063810  CALM3; calmodulin-3 [KO:K02183]
128064162  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
128064178  FGF21; fibroblast growth factor 21 [KO:K22429]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128064257  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
128064401  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
128064511  P2RX5; P2X purinoceptor 5 [KO:K05219]
128064512  P2RX1; P2X purinoceptor 1 [KO:K05215]
128064538  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
128064567  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
128064784  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
128065005  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
128065116  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
128065144  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
128065152  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
128065196  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
128065233  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128065652  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128065968  FGF10; fibroblast growth factor 10 [KO:K04358]
128066098  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
128066123  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
128066262  FGF18; fibroblast growth factor 18 [KO:K04358]
128066365  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128066728  [KO:K03916]
128066803  [KO:K04809]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128067338  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
128067669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
128067818  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
128067938  FGF8; fibroblast growth factor 8 [KO:K04358]
128067942  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
128067997  ADRB1; beta-1 adrenergic receptor [KO:K04141]
128068006  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
128068182  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
128068228  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
128068312  ADRB3; beta-3 adrenergic receptor [KO:K04143]
128068325  VEGFC; vascular endothelial growth factor C [KO:K05449]
128068355  FGF20; fibroblast growth factor 20 [KO:K04358]
128068375  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128068545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
128068704  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
128068711  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
128068748  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
128068942  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
128068993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
128069166  FGF4; fibroblast growth factor 4 [KO:K04358]
128069196  FGF3; fibroblast growth factor 3 [KO:K04358]
128069264  FGF19; fibroblast growth factor 19 [KO:K22603]
128069702  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
128069760  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
128069928  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
128070004  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
128070059  GRPR; gastrin-releasing peptide receptor [KO:K04169]
128070228  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
128070292  HRH1; histamine H1 receptor [KO:K04149]
128070311  VEGFD; vascular endothelial growth factor D [KO:K05449]
128070322  FGF16; fibroblast growth factor 16 [KO:K04358]
128070360  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
128070564  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
128070620  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
128070914  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128071087  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
btax04010  MAPK signaling pathway
btax04070  Phosphatidylinositol signaling system
btax04210  Apoptosis
btax04720  Long-term potentiation
btax04730  Long-term depression
KO pathway
ko04020   

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