KEGG   PATHWAY: caua03013
Entry
caua03013                   Pathway                                
Name
Nucleocytoplasmic transport - Carassius auratus (goldfish)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
caua03013  Nucleocytoplasmic transport
caua03013

Other DBs
GO: 0050658
Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113109147  aaas; aladin [KO:K14320]
113062451  nucleoporin-like protein 2 [KO:K14321]
113062501  nucleoporin-like protein 2 [KO:K14321]
113106961  gle1; nucleoporin GLE1 [KO:K18723]
113041601  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
113055105  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
113069403  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
113065692  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
113050713  rae1; mRNA export factor isoform X1 [KO:K14298]
113038383  nuclear pore complex protein Nup98-Nup96-like isoform X1 [KO:K14297]
113068070  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
113086616  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
113049773  nup88; nuclear pore complex protein Nup88 [KO:K14318]
113109137  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1 [KO:K12172] [EC:2.3.2.-]
113109138  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
113067386  ran GTPase-activating protein 1-like [KO:K14319]
113067767  ran GTPase-activating protein 1-like [KO:K14319]
113056051  ran GTPase-activating protein 1-like [KO:K14319]
113111717  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
113047660  SUMO-conjugating enzyme UBC9-like [KO:K10577]
113092781  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
113042099  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
113049723  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
113071512  SUMO-conjugating enzyme UBC9-B [KO:K10577]
113046812  SUMO-conjugating enzyme UBC9-like [KO:K10577]
113092351  small ubiquitin-related modifier 1 [KO:K12160]
113092815  small ubiquitin-related modifier 3-like [KO:K12160]
113067476  small ubiquitin-related modifier 2 [KO:K12160]
113067867  small ubiquitin-related modifier 2 [KO:K12160]
113055712  small ubiquitin-related modifier 2 [KO:K12160]
113055721  small ubiquitin-related modifier 2 [KO:K12160]
113108846  small ubiquitin-related modifier 3-like [KO:K12160]
113050681  small ubiquitin-related modifier 3-like [KO:K12160]
113050826  small ubiquitin-related modifier 3-like [KO:K12160]
113050865  small ubiquitin-related modifier 1 [KO:K12160]
113097980  small ubiquitin-related modifier 3-like [KO:K12160]
113053602  small ubiquitin-related modifier 3-like isoform X1 [KO:K12160]
113067168  nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
113054909  nuclear pore complex protein Nup85-like isoform X1 [KO:K14304]
113054920  nuclear pore complex protein Nup85-like isoform X1 [KO:K14304]
113067376  nuclear pore complex protein Nup85-like isoform X1 [KO:K14304]
113067856  nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
113070588  protein SEC13 homolog [KO:K14004]
113065095  protein SEC13 homolog [KO:K14004]
113061881  nup107; nuclear pore complex protein Nup107 [KO:K14301]
113059079  nup133; nuclear pore complex protein Nup133 [KO:K14300]
113116203  nucleoporin SEH1-like [KO:K14299]
113060114  nucleoporin SEH1-like [KO:K14299]
113119179  nucleoporin SEH1 isoform X1 [KO:K14299]
113073102  nup43; nucleoporin Nup43 [KO:K14305]
113062831  nup37; LOW QUALITY PROTEIN: nucleoporin Nup37 [KO:K14302]
113060702  LOW QUALITY PROTEIN: protein ELYS-like [KO:K25129]
113117642  LOW QUALITY PROTEIN: protein ELYS-like [KO:K25129]
113073886  protein ELYS-like [KO:K25129]
113113385  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
113066194  nucleoporin p58/p45-like isoform X1 [KO:K14307]
113042483  nucleoporin p58/p45-like isoform X1 [KO:K14307]
113073265  nucleoporin p58/p45-like isoform X1 [KO:K14307]
113083599  nuclear pore complex protein Nup54-like isoform X1 [KO:K14308]
113088018  nuclear pore complex protein Nup54-like [KO:K14308]
113118220  nup205; nuclear pore complex protein Nup205 [KO:K14310]
113064430  nup188; nucleoporin NUP188 homolog [KO:K14311]
113107692  nup155; nuclear pore complex protein Nup155 [KO:K14312]
113061484  nuclear pore complex protein Nup93-like [KO:K14309]
113118328  nup93; nuclear pore complex protein Nup93 [KO:K14309]
113053596  nucleoporin NUP35 [KO:K14313]
113074455  nucleoporin NUP35-like [KO:K14313]
113045942  nucleoporin NDC1 isoform X1 [KO:K14315]
113117407  nucleoporin NDC1-like isoform X1 [KO:K14315]
113068637  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
113116745  nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
113054462  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
113110048  nuclear envelope pore membrane protein POM 121-like isoform X1 [KO:K14316]
113114050  transmembrane protein 33-like [KO:K20724]
113091100  transmembrane protein 33-like [KO:K20724]
113120752  nucleoprotein TPR-like [KO:K09291]
113062668  nucleoprotein TPR-like [KO:K09291]
113062966  nucleoprotein TPR-like isoform X1 [KO:K09291]
113115881  nucleoprotein TPR-like isoform X1 [KO:K09291]
113045802  nucleoprotein TPR-like [KO:K09291]
113048074  nuclear pore complex protein Nup50-like [KO:K14295]
113057109  nuclear pore complex protein Nup50-like [KO:K14295]
113119268  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
113093806  LOW QUALITY PROTEIN: nuclear pore complex protein Nup153-like [KO:K14296]
113092903  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
113050821  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
113066284  importin subunit alpha-5-like isoform X1 [KO:K23940]
113041894  importin subunit alpha-5 isoform X1 [KO:K23940]
113047802  importin subunit alpha-1-like [KO:K15043]
113109862  importin subunit alpha-5-like [KO:K15043]
113046807  importin subunit alpha-1-like [KO:K15043]
113066216  importin subunit alpha-4-like isoform X1 [KO:K23583]
113115423  importin subunit alpha-3-like [KO:K23583]
113098203  importin subunit alpha-4 [KO:K23583]
113058226  importin subunit alpha-3 [KO:K23583]
113074088  importin subunit alpha-4 [KO:K23583]
113119556  importin subunit alpha-7 [KO:K15042]
113079852  importin subunit alpha-6 [KO:K15042]
113116039  importin subunit alpha-6-like isoform X1 [KO:K15042]
113099641  importin subunit alpha-6 [KO:K15042]
113091459  importin subunit alpha-7-like [KO:K15042]
113119133  importin subunit beta-1 [KO:K14293]
113068429  importin subunit beta-1-like [KO:K14293]
113076089  transportin-1-like isoform X1 [KO:K18752]
113094017  transportin-1 isoform X1 [KO:K18752]
113049536  transportin-1 isoform X1 [KO:K18752]
113076700  transportin-2 isoform X1 [KO:K18727]
113097616  transportin-2-like isoform X1 [KO:K18727]
113057859  transportin-2-like [KO:K18727]
113052027  transportin-2-like [KO:K18727]
113046665  transportin-2-like isoform X1 [KO:K18727]
113060416  transportin-3-like [KO:K15436]
113047996  transportin-3 isoform X1 [KO:K15436]
113048007  transportin-3 [KO:K15436]
113071157  transportin-3-like [KO:K15436]
113042332  ipo4; importin-4 [KO:K20221]
113044595  importin-5 [KO:K20222]
113100208  importin-5-like [KO:K20222]
113106489  importin-7 isoform X1 [KO:K20223]
113051776  importin-7-like [KO:K20223]
113048296  ipo8; importin-8 isoform X1 [KO:K18755]
113055187  importin-9 isoform X1 [KO:K20224]
113111177  importin-9-like isoform X1 [KO:K20224]
113096371  ipo11; importin-11 [KO:K25201]
113093339  importin-13-like [KO:K25202]
113120627  importin-13-like [KO:K25202]
113037898  importin-13-like [KO:K25202]
113046043  importin-13-like isoform X1 [KO:K25202]
113066644  snurportin-1-like isoform X1 [KO:K13151]
113043155  snurportin-1-like isoform X1 [KO:K13151]
113043196  snurportin-1-like isoform X1 [KO:K13151]
113079168  snurportin-1-like [KO:K13151]
113076712  exportin-1-like [KO:K14290]
113093179  exportin-1-like [KO:K14290]
113097614  exportin-1-like [KO:K14290]
113117396  exportin-1 [KO:K14290]
113059941  exportin-1-like [KO:K14290]
113055121  exportin-2 [KO:K18423]
113069423  exportin-2-like [KO:K18423]
113048464  exportin-T [KO:K14288]
113085445  exportin-T-like [KO:K14288]
113064893  exportin-T-like isoform X1 [KO:K14288]
113108787  exportin-4-like isoform X1 [KO:K25203]
113071897  LOW QUALITY PROTEIN: exportin-4-like [KO:K25203]
113053389  exportin-4-like [KO:K25203]
113057458  xpo5; exportin-5 isoform X1 [KO:K14289]
113067634  exportin-6 [KO:K25204]
113050570  exportin-6-like [KO:K25204]
113054252  exportin-7 isoform X1 [KO:K18460]
113109791  exportin-7-like [KO:K18460]
113113662  GTP-binding nuclear protein Ran [KO:K07936]
113069566  GTP-binding nuclear protein Ran [KO:K07936]
113041085  elongation factor 1-alpha 2-like [KO:K03231]
113106385  elongation factor 1-alpha 1-like [KO:K03231]
113112673  elongation factor 1-alpha 1-like [KO:K03231]
113119291  elongation factor 1-alpha [KO:K03231]
113119292  elongation factor 1-alpha-like [KO:K03231]
113042367  elongation factor 1-alpha-like [KO:K03231]
113062123  elongation factor 1-alpha-like [KO:K03231]
113062124  elongation factor 1-alpha-like [KO:K03231]
113044406  elongation factor 1-alpha 1-like [KO:K03231]
113056940  elongation factor 1-alpha 1 [KO:K03231]
113098299  elongation factor 1-alpha 2 [KO:K03231]
113082137  elongation factor 1-alpha 2-like [KO:K03231]
113109505  phax; phosphorylated adapter RNA export protein [KO:K14291]
113113847  nuclear cap-binding protein subunit 1-like [KO:K12882]
113057649  nuclear cap-binding protein subunit 1 [KO:K12882]
113039714  nuclear cap-binding protein subunit 2-like [KO:K12883]
113065220  nuclear cap-binding protein subunit 2 [KO:K12883]
113115424  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
113115730  RNA-binding protein 8A-like [KO:K12876]
113059267  RNA-binding protein 8A [KO:K12876]
113107225  protein mago nashi homolog [KO:K12877]
113069935  protein mago nashi homolog [KO:K12877]
113044404  protein CASC3-like [KO:K14323]
113046708  protein CASC3 isoform X1 [KO:K14323]
113048917  eukaryotic initiation factor 4A-I-like [KO:K13025] [EC:5.6.2.7]
113055575  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
113084883  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
113111261  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
113111286  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
113119896  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
113044984  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
113052127  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
113105709  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
113108562  histone deacetylase complex subunit SAP18 [KO:K14324]
113108814  histone deacetylase complex subunit SAP18 [KO:K14324]
113053398  histone deacetylase complex subunit SAP18-like [KO:K14324]
113048922  RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
113067791  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
113067792  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
113060777  pinin-like [KO:K13114]
113060961  pinin-like [KO:K13114]
113080425  pinin-like [KO:K13114]
113117620  pinin-like [KO:K13114]
113052800  THO complex subunit 4-like [KO:K12881]
113046578  THO complex subunit 4-like isoform X1 [KO:K12881]
113045250  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
113111371  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
113111921  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
113048454  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
113064934  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
113113930  regulator of nonsense transcripts 3B-like [KO:K14328]
113108141  regulator of nonsense transcripts 3A-like isoform X1 [KO:K14328]
113108477  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
113057883  regulator of nonsense transcripts 3B-like [KO:K14328]
113057893  regulator of nonsense transcripts 3B-like isoform X1 [KO:K14328]
113053088  regulator of nonsense transcripts 3A-like isoform X1 [KO:K14328]
113113761  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
113038521  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
113064342  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
113064343  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
113114188  nxt2; NTF2-related export protein 2 [KO:K14285]
113090831  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
113095737  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
113117446  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
113106910  partner of Y14 and mago B-like [KO:K14294]
113052680  partner of Y14 and mago B-like isoform X1 [KO:K14294]
113089466  partner of Y14 and mago B-like isoform X1 [KO:K14294]
113046116  THO complex subunit 1-like [KO:K12878]
113039930  THO complex subunit 1-like [KO:K12878]
113113390  THO complex subunit 2-like isoform X1 [KO:K12879]
113113393  THO complex subunit 2-like isoform X1 [KO:K12879]
113066371  THO complex subunit 5 homolog [KO:K13174]
113066567  THO complex subunit 5 homolog isoform X1 [KO:K13174]
113042881  THO complex subunit 5 homolog isoform X1 [KO:K13174]
113042910  THO complex subunit 5 homolog isoform X1 [KO:K13174]
113045588  thoc6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
113092090  THO complex subunit 7 homolog [KO:K13176]
113076102  THO complex subunit 7 homolog [KO:K13176]
113055257  THO complex subunit 7 homolog [KO:K13176]
113114275  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
caua03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

DBGET integrated database retrieval system