Entry Name Platelet activation - Cricetulus griseus (Chinese hamster)
Description Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Cricetulus griseus (Chinese hamster) [GN:
cge ]
Gene 100689071 Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639 ]
100758784 Arhgef1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330 ]
100765006 Arhgef12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532 ]
100761524 Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269 ] [EC:3.1.3.16 ]
100774547 Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269 ] [EC:3.1.3.16 ]
100754718 Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270 ]
100752394 Orai1; calcium release-activated calcium channel protein 1 isoform X2 [KO:K16056 ]
100764450 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958 ]
100758965 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959 ]
100751775 inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960 ]
100689066 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
100760134 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
100770957 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100751979 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
100773337 Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2 [KO:K17704 ]
100689068 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
100689072 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
100689070 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100689067 Gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
100765862 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
100751224 Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X4 [KO:K21290 ]
100751518 Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290 ]
100756352 Vasp; vasodilator-stimulated phosphoprotein isoform X2 [KO:K06274 ]
100752481 Arhgap35; rho GTPase-activating protein 35 isoform X1 [KO:K05732 ]
103161891 low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06472 ]
100768356 Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
100689251 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100769225 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100689252 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100771181 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649 ]
100750761 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
100774067 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100770316 Gp1ba; platelet glycoprotein Ib alpha chain isoform X2 [KO:K06261 ]
100757957 Snap23; synaptosomal-associated protein 23 isoform X1 [KO:K08508 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Li Z, Delaney MK, O'Brien KA, Du X
Title Signaling during platelet adhesion and activation.
Journal Reference Authors Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title Blood platelet biochemistry.
Journal Reference Authors Jurk K, Kehrel BE
Title Platelets: physiology and biochemistry.
Journal Reference Authors Offermanns S
Title Activation of platelet function through G protein-coupled receptors.
Journal Reference Authors Varga-Szabo D, Pleines I, Nieswandt B
Title Cell adhesion mechanisms in platelets.
Journal Reference Authors Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal Reference Authors Bergmeier W, Stefanini L
Title Novel molecules in calcium signaling in platelets.
Journal Reference Authors Cifuni SM, Wagner DD, Bergmeier W
Title CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal Reference Authors Heemskerk JW, Mattheij NJ, Cosemans JM
Title Platelet-based coagulation: different populations, different functions.
Journal Reference Authors Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title Platelet receptors and signaling in the dynamics of thrombus formation.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Angiolillo DJ, Ferreiro JL
Title Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal Reference Authors Joo SJ
Title Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal Reference Authors Harper MT, Poole AW
Title Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal Reference Authors Fitch-Tewfik JL, Flaumenhaft R
Title Platelet granule exocytosis: a comparison with chromaffin cells.
Journal Reference Authors Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal Related cge04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
