KEGG   PATHWAY: cide04218
Entry
cide04218                   Pathway                                
Name
Cellular senescence - Ctenopharyngodon idella (grass carp)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
cide04218  Cellular senescence
cide04218

Other DBs
GO: 0090398
Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127495355  transforming growth factor, beta 1a isoform X1 [KO:K13375]
127503585  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
127494595  transforming growth factor beta-2 proprotein [KO:K13376]
127496922  transforming growth factor beta-2 proprotein [KO:K13376]
127498052  transforming growth factor beta-3 proprotein [KO:K13377]
127506415  TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
127498181  TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
127497383  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
127519363  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127520704  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
127499865  mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
127516003  mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
127522801  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
127500750  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127509428  cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
127516057  G1/S-specific cyclin-D1 [KO:K04503]
127506694  G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
127510934  G1/S-specific cyclin-D2b [KO:K10151]
127520610  G1/S-specific cyclin-D3 [KO:K10152]
127503257  retinoblastoma-associated protein [KO:K06618]
127513872  retinoblastoma-like protein 1 [KO:K04681]
127507065  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
127505453  transcription factor E2F1 [KO:K17454]
127505454  transcription factor E2F1-like [KO:K17454]
127498968  transcription factor E2F2 [KO:K09389]
127500812  transcription factor E2F3 isoform X1 [KO:K06620]
127507394  transcription factor E2F4 [KO:K04682]
127505883  transcription factor E2F5 [KO:K04682]
127522246  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127496217  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127504512  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127504906  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127514273  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
127502660  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127512708  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127496190  forkhead box protein O1-A isoform X1 [KO:K07201]
127520074  forkhead box protein O1-B [KO:K07201]
127499197  forkhead box protein O3a [KO:K09408]
127501883  forkhead box protein O3B [KO:K09408]
127510898  cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
127521414  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
127522811  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
127515472  G1/S-specific cyclin-E1 [KO:K06626]
127497239  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
127500840  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
127501183  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
127506985  GTPase KRas isoform X1 [KO:K07827]
127508487  zgc:55558; GTPase KRas [KO:K07827]
127517208  GTPase NRas [KO:K07828]
127515439  ras-related protein R-Ras2 isoform X1 [KO:K07830]
127508034  ras-related protein R-Ras [KO:K07830]
127521489  ras-related protein M-Ras [KO:K07831]
127518891  ras-related protein M-Ras [KO:K07831]
127507367  HRas proto-oncogene, GTPase a [KO:K02833]
127516364  HRas proto-oncogene, GTPase b [KO:K02833]
127499652  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127521951  v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127502735  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127525380  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127498588  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127498690  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127513634  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127503535  TSC complex subunit 1b isoform X1 [KO:K07206]
127512701  TSC complex subunit 1a isoform X1 [KO:K07206]
127520890  tuberin isoform X1 [KO:K07207]
127513887  ras homolog, mTORC1 binding like 1 [KO:K07208]
127517590  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
127499167  phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127523380  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127524433  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
127521691  cyclin-A1 [KO:K06627]
127494198  cyclin-A2 [KO:K06627]
127522950  v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
127502704  protein lin-9 homolog [KO:K21773]
127495960  protein lin-37 homolog [KO:K21774]
127498537  protein lin-52 homolog isoform X1 [KO:K21775]
127521499  protein lin-54 homolog isoform X1 [KO:K21776]
127522189  histone-binding protein RBBP7 isoform X1 [KO:K10752]
127500738  histone-binding protein RBBP4 [KO:K10752]
127510488  LOW QUALITY PROTEIN: forkhead box protein M1 [KO:K09406]
127506190  transcriptional regulator Myc-A [KO:K04377]
127506739  transcriptional regulator Myc-B [KO:K04377]
127510532  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
127516134  cellular tumor antigen p53-like [KO:K04451]
127512451  cellular tumor antigen p53 isoform X1 [KO:K04451]
127522821  ras association domain-containing protein 5 isoform X1 [KO:K08015]
127510760  ras association domain-containing protein 3 isoform X1 [KO:K08015]
127494109  F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
127520053  F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
127499447  homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
127506737  LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 3a [KO:K08826] [EC:2.7.11.1]
127500098  homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
127522462  LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1 [KO:K08826] [EC:2.7.11.1]
127504983  homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
127515760  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127508387  protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
127502235  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127523467  protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
127512734  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
127513167  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
127498956  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127522563  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127504685  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127499431  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127502256  dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127519987  dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127509562  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127513496  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
127499696  protein C-ets-1 isoform X1 [KO:K02678]
127524204  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
127499931  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127522287  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
127517001  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127517204  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
127510537  mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
127510539  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127505446  zgc:171775; LOW QUALITY PROTEIN: STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127515000  growth arrest and DNA-damage-inducible, alpha, b isoform X1 [KO:K04402]
127522598  growth arrest and DNA-damage-inducible, beta a [KO:K04402]
127518010  growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
127496831  growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
127503716  growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
127498920  growth arrest and DNA-damage-inducible, beta b [KO:K04402]
127498819  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
127499394  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
127512710  G2/mitotic-specific cyclin-B1 [KO:K05868]
127515821  G2/mitotic-specific cyclin-B2 [KO:K21770]
127516277  G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
127495341  double-strand break repair protein MRE11 isoform X1 [KO:K10865]
127503524  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
127503525  DNA repair protein RAD50-like isoform X1 [KO:K10866] [EC:3.6.-.-]
127504091  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
127497919  nibrin [KO:K10867]
127496255  serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
127513317  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
127494167  cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
127518117  cell cycle checkpoint control protein RAD9B [KO:K10995]
127496089  cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
127499415  serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
127504163  serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
127494206  sequestosome-1 isoform X1 [KO:K14381]
127501956  transcription factor GATA-4-like [KO:K09183]
127502347  transcription factor GATA-4-like [KO:K09183]
127525667  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
127515912  transcription factor p65 [KO:K04735]
127501686  interleukin-6 [KO:K05405]
127516705  C-X-C motif chemokine 19 [KO:K10030]
127511914  interleukin-8 [KO:K10030]
127502180  insulin-like growth factor-binding protein 3 [KO:K10138]
127515273  plasminogen activator inhibitor 1 [KO:K03982]
127503719  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
127522414  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
127517896  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
127517920  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
127499397  mRNA decay activator protein ZFP36L1 [KO:K18753]
127494967  zgc:114130; mRNA decay activator protein ZFP36L1 [KO:K18753]
127501814  mRNA decay activator protein ZFP36L1b [KO:K18753]
127523769  mRNA decay activator protein ZFP36L2-A-like [KO:K18753]
127523790  mRNA decay activator protein ZFP36L2-A-like [KO:K18753]
127524765  mRNA decay activator protein ZFP36L2-like [KO:K18753]
127498270  mRNA decay activator protein ZFP36L1a [KO:K18753]
127522496  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127516967  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127513360  transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
127499641  transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
127515870  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
127503143  si:dkeyp-50d11.2; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
127524775  calpain 1, (mu/I) large subunit a isoform X1 [KO:K01367] [EC:3.4.22.52]
127520138  calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
127498406  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
127498407  calpain-8-like [KO:K01367] [EC:3.4.22.52]
127521576  calpain-8 [KO:K03853] [EC:3.4.22.53]
127521577  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127524777  calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
127520139  calpain 2, (m/II) large subunit b isoform X1 [KO:K03853] [EC:3.4.22.53]
127520684  calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
127515547  calmodulin-like protein 4a [KO:K02183]
127507638  calmodulin-like protein 4 [KO:K02183]
127494994  calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
127502289  calmodulin-1b [KO:K02183]
127523824  calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
127524770  calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
127504069  calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
127498959  calmodulin-1a [KO:K02183]
127515598  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127494678  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127504005  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127513672  protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
127520624  protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
127509346  calcineurin subunit B type 1b [KO:K06268]
127524878  calcineurin subunit B type 1 [KO:K06268]
127501241  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
127514671  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
127504966  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
127507856  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127515993  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
127502032  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
127514964  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127522689  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127499474  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127517038  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
127510559  ADP/ATP translocase 1 [KO:K05863]
127519433  ADP/ATP translocase 3 [KO:K05863]
127525677  ADP/ATP translocase 2 [KO:K05863]
127513667  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
127525672  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
127504160  voltage-dependent anion-selective channel protein 1 [KO:K05862]
127523219  voltage-dependent anion-selective channel protein 2 [KO:K15040]
127517701  voltage-dependent anion-selective channel protein 3 [KO:K15041]
127521015  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
127525266  calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
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Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
cide04020  Calcium signaling pathway
cide04068  FoxO signaling pathway
cide04110  Cell cycle
cide04115  p53 signaling pathway
cide04150  mTOR signaling pathway
KO pathway
ko04218   
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