KEGG   PATHWAY: clv04510
Entry
clv04510                    Pathway                                
Name
Focal adhesion - Columba livia (rock pigeon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
clv04510  Focal adhesion
clv04510

Other DBs
GO: 0005925
Organism
Columba livia (rock pigeon) [GN:clv]
Gene
102092022  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102090396  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102092442  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102088881  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102090256  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102083797  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102083978  collagen alpha-3(IV) chain [KO:K06237]
102089261  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102085871  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102087195  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
102087375  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102093355  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102089916  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
102091178  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102091755  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102084863  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102091939  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
102087859  LAMA1; laminin subunit alpha-1 [KO:K05637]
110358475  laminin subunit alpha-5-like [KO:K05637]
102092628  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
102096169  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102095906  LAMA4; laminin subunit alpha-4 [KO:K06241]
102091353  LAMB1; laminin subunit beta-1 [KO:K05636]
102097768  LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
102097594  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
102086173  LAMB3; laminin subunit beta-3 [KO:K06244]
102091528  LAMB4; laminin subunit beta-4 [KO:K06245]
102094157  LAMC1; laminin subunit gamma-1 [KO:K05635]
102093606  LAMC2; laminin subunit gamma-2 [KO:K06246]
102091335  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
102087447  CHAD; chondroadherin [KO:K06248]
102093832  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
102091738  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
102098894  COMP; cartilage oligomeric matrix protein [KO:K04659]
102095550  THBS3; thrombospondin-3 [KO:K04659]
102088266  THBS2; thrombospondin-2 [KO:K04659]
102097761  THBS4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
102090641  FN1; fibronectin [KO:K05717]
102083765  SPP1; osteopontin isoform X1 [KO:K06250]
102094351  VTN; vitronectin [KO:K06251]
102097682  TNC; tenascin isoform X4 [KO:K06252]
102096667  TNR; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
102094798  VWF; von Willebrand factor [KO:K03900]
102092084  IBSP; bone sialoprotein 2 [KO:K06253]
102091068  ITGA1; integrin alpha-1 [KO:K06480]
102091733  ITGA2; integrin alpha-2 [KO:K06481]
102098721  ITGA2B; integrin alpha-IIb [KO:K06476]
102092573  ITGA3; integrin alpha-3 [KO:K06482]
102097249  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
102098455  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102088100  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
102085272  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102091471  ITGA9; integrin alpha-9 [KO:K06585]
102094194  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
102097696  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
102089491  ITGB1; integrin beta-1 [KO:K05719]
102089259  ITGB3; integrin beta-3 isoform X3 [KO:K06493]
102087266  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102096917  ITGB5; integrin beta-5 [KO:K06588]
102089659  ITGB6; integrin beta-6 [KO:K06589]
102094007  ITGB8; integrin beta-8 [KO:K06591]
102091819  EMP2; epithelial membrane protein 2 [KO:K26256]
102085857  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102096932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102088608  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102087107  PDGFC; platelet-derived growth factor C [KO:K05450]
102083886  EGF; pro-epidermal growth factor [KO:K04357]
102092089  IGF1; insulin-like growth factor I [KO:K05459]
102087578  VEGFA; vascular endothelial growth factor A [KO:K05448]
102097929  PGF; placenta growth factor [KO:K16859]
102094006  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
102091004  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102084988  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102087625  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102096790  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102089963  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102095316  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102097879  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102094103  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102087545  vascular endothelial growth factor receptor kdr-like isoform X2 [KO:K05096] [EC:2.7.10.1]
102090209  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
102091194  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102094013  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102085803  EMP1; epithelial membrane protein 1 [KO:K26255]
102091546  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
102089656  ARHGAP35; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
102095880  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
102086675  RHOA; transforming protein RhoA [KO:K04513]
102097361  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102084971  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102085726  myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351]
102098030  myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351]
102095544  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102095132  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
102098580  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102098877  myosin regulatory light chain 2, smooth muscle minor isoform isoform X2 [KO:K12757]
102086082  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102096027  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102083732  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102098984  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
102090398  protein phosphatase 1 regulatory subunit 12B [KO:K12329]
102088141  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102093425  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102094050  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102095697  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102098142  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102093468  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102094562  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
102092807  actin, cytoplasmic type 5 [KO:K05692]
102086906  ACTB; actin, cytoplasmic 1 [KO:K05692]
102091503  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102084552  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102088244  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
102090066  LOW QUALITY PROTEIN: alpha-actinin-4-like [KO:K05699]
102096145  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
102097570  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
102090492  FLNB; filamin-B [KO:K27392]
102084396  PXN; paxillin isoform X3 [KO:K05760]
102094280  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
102094852  ZYX; zyxin isoform X2 [KO:K06273]
102096474  VCL; vinculin [KO:K05700]
102097884  PARVB; beta-parvin isoform X1 [KO:K06275]
102098181  PARVG; gamma-parvin isoform X1 [KO:K06275]
102086704  PARVA; alpha-parvin [KO:K06275]
102092469  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102095269  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102098970  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102090893  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
102088707  CTNNB1; catenin beta-1 [KO:K02105]
102084059  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102090291  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102093049  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102083735  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102095297  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102084293  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102084272  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X4 [KO:K02649]
102092838  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102084904  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102094724  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102088090  VAV1; proto-oncogene vav [KO:K05730]
102089895  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
102094213  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102091892  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102092145  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102094546  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102084510  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102088494  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102088276  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102098855  PAK5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
102096449  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102098077  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102090770  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
102091247  CRK; adapter molecule crk [KO:K04438]
102092831  CRKL; crk-like protein [KO:K04438]
102083486  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102093050  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
102089030  RAP1A; ras-related protein Rap-1A [KO:K04353]
102083646  RAP1B; ras-related protein Rap-1b [KO:K07836]
102085840  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102087983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102085027  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102092209  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102088487  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102091371  CAV1; caveolin-1 [KO:K06278]
102098428  CAV3; caveolin-3 [KO:K12959]
102095466  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
102093713  SHC1; SHC-transforming protein 1 [KO:K06279]
102088882  SHC2; SHC-transforming protein 2 [KO:K17447]
102091397  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102088829  SHC4; SHC-transforming protein 4 [KO:K17449]
102098952  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102095838  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
102089495  SOS2; son of sevenless homolog 2 [KO:K03099]
102091763  HRAS; GTPase HRas [KO:K02833]
102096788  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102096091  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102084879  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102086245  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102093196  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
102090134  CCND3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
102090342  inhibitor of apoptosis protein [KO:K16060]
102088054  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
102092853  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
clv04010  MAPK signaling pathway
clv04060  Cytokine-cytokine receptor interaction
clv04070  Phosphatidylinositol signaling system
clv04110  Cell cycle
clv04310  Wnt signaling pathway
clv04512  ECM-receptor interaction
clv04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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