KEGG   PATHWAY: ecb05020
Entry
ecb05020                    Pathway                                
Name
Prion disease - Equus caballus (horse)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ecb05020  Prion disease
ecb05020

Organism
Equus caballus (horse) [GN:ecb]
Gene
100065904  PRNP; major prion protein precursor [KO:K05634]
100067189  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
100062164  NCAM1; neural cell adhesion molecule 1 isoform X9 [KO:K06491]
100055269  LAMC1; laminin subunit gamma-1 [KO:K05635]
100033855  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100055100  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102149085  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100059861  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100051329  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100063746  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100052410  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102148904  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100062954  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
111774159  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100058760  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100067235  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
100066488  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100052709  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100053417  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100034090  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
100057437  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
100071830  RYR3; ryanodine receptor 3 [KO:K04963]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100069290  caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100064276  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100050762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100059103  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100071908  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100146128  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100073016  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100052552  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100053958  CYCS; cytochrome c [KO:K08738]
111768755  cytochrome c, testis-specific [KO:K08738]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100072824  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
807846  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807844  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807855  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807852  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807851  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807853  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807848  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100059569  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100054445  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100057691  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X4 [KO:K03944]
100058835  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100061811  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
111772123  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
111767785  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
111767790  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100052169  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100052985  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
106783042  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100071532  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100066991  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100067562  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100051504  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100057698  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100069079  NDUFAB1; acyl carrier protein, mitochondrial isoform X1 [KO:K03955]
100065070  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100146253  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100630425  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100064695  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100067936  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100070815  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100058402  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100630340  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100064992  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
100060451  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100057623  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100065553  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100060719  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100066330  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2 [KO:K03934] [EC:7.1.1.2]
100066089  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100058223  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
100063168  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100054377  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100071879  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100068855  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100053392  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100629515  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100630892  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100034244  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100050091  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100065940  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X3 [KO:K00236]
100629334  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100053634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
807847  CYTB; cytochrome b [KO:K00412]
100146668  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
100053786  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
100057847  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100051878  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100059627  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
111767815  cytochrome b-c1 complex subunit 8 [KO:K00418]
100630846  cytochrome b-c1 complex subunit 9 [KO:K00419]
100147519  cytochrome b-c1 complex subunit 10 [KO:K00420]
807856  COX3; cytochrome c oxidase subunit III [KO:K02262]
807850  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807845  COX2; cytochrome c oxidase subunit II [KO:K02261]
100053548  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100056171  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100051391  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100061973  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100053420  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100063197  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100051249  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
102149678  cytochrome c oxidase subunit 6B2 [KO:K02267]
100055813  cytochrome c oxidase subunit 6C [KO:K02268]
100053736  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100630209  LOW QUALITY PROTEIN: uncharacterized protein LOC100630209 [KO:K02270]
106782100  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100630758  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100629332  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100630549  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111770393  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
111775959  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100053178  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100059825  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100069978  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
100146850  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100630568  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
807854  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100058893  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100069523  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100053347  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100064131  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100052170  ATP5PD; ATP synthase subunit d, mitochondrial isoform X2 [KO:K02138]
100052131  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100066379  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
807849  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100050805  PSMA6; proteasome subunit alpha type-6 isoform X2 [KO:K02730] [EC:3.4.25.1]
100064293  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100050569  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
100064417  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
100057828  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100061457  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
100056224  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100050987  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
100072870  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100067317  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100068477  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100055325  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100052570  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100051957  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100059821  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100058456  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100062573  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100064604  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100049903  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
100051468  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
100053987  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
100059081  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100057015  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X2 [KO:K03032]
100147612  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100058668  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100063689  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100071770  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100055920  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100067363  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100050948  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100216429  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100051409  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
100064192  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102150324  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
100067655  C5; complement C5 [KO:K03994]
100065952  C6; complement component C6 [KO:K03995]
100066126  C7; complement component C7 isoform X3 [KO:K03996]
100059461  C8A; complement component C8 alpha chain [KO:K03997]
100059423  C8B; complement component C8 beta chain [KO:K03998]
100147492  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
100034183  C9; complement component C9 precursor [KO:K04000]
100058097  C1QA; complement C1q subcomponent subunit A [KO:K03986]
100071667  C1QB; complement C1q subcomponent subunit B [KO:K03987]
100058056  C1QC; complement C1q subcomponent subunit C [KO:K03988]
100050827  HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
100051595  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100050904  heat shock 70 kDa protein 1-like [KO:K03283]
100009679  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111769297  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
100068764  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100055975  CAV1; caveolin-1 [KO:K06278]
100071136  CAV2; caveolin-2 [KO:K12958]
100058881  CAV3; caveolin-3 [KO:K12959]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100051333  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100050132  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100049843  CYBA; cytochrome b-245 light chain isoform X1 [KO:K08009]
100069566  NCF4; neutrophil cytosol factor 4 [KO:K08012]
100146522  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100051787  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100072574  EGR1; early growth response protein 1 [KO:K09203]
100033925  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
100064969  IL1A; interleukin-1 alpha precursor [KO:K04383]
100034237  IL1B; interleukin-1 beta [KO:K04519]
100052414  IL1B; interleukin-1 beta [KO:K04519]
111768185  interleukin-1 beta-like [KO:K04519]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100033834  TNF; tumor necrosis factor [KO:K03156]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100063080  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100067965  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100058658  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
100061228  KIF5B; kinesin-1 heavy chain [KO:K10396]
100050542  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100056413  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
100055017  KLC4; kinesin light chain 4 [KO:K10407]
100055290  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100147291  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
100052297  KLC2; kinesin light chain 2 [KO:K10407]
100059285  tubulin alpha-1D chain [KO:K07374]
100051840  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100051901  tubulin alpha-1C chain [KO:K07374]
100052388  tubulin alpha-3 chain [KO:K07374]
100054576  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
100065732  tubulin alpha-3 chain [KO:K07374]
100059249  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100146855  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100059091  tubulin alpha-1B chain [KO:K07374]
100072403  tubulin alpha-3 chain [KO:K07374]
100050361  tubulin beta-2B chain [KO:K07375]
100056684  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100051013  TUBB; tubulin beta chain [KO:K07375]
100058421  TUBB6; tubulin beta-6 chain [KO:K07375]
100629875  TUBB2A; tubulin beta-2A chain [KO:K07375]
100059595  TUBB4B; tubulin beta-4B chain [KO:K07375]
100065776  TUBB4A; tubulin beta-4A chain [KO:K07375]
111772826  TUBB3; tubulin beta-3 chain [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
DOI:10.1017/erm.2016.8
Reference
PMID:25584786
  Authors
Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
  Journal
Mol Cell Neurosci 66:12-20 (2015)
DOI:10.1016/j.mcn.2014.12.009
Reference
PMID:20889378
  Authors
Soto C, Satani N
  Title
The intricate mechanisms of neurodegeneration in prion diseases.
  Journal
Trends Mol Med 17:14-24 (2011)
DOI:10.1016/j.molmed.2010.09.001
Reference
PMID:27060771
  Authors
Mays CE, Soto C
  Title
The stress of prion disease.
  Journal
Brain Res 1648:553-560 (2016)
DOI:10.1016/j.brainres.2016.04.009
Reference
PMID:32565065
  Authors
Jones E, Mead S
  Title
Genetic risk factors for Creutzfeldt-Jakob disease.
  Journal
Neurobiol Dis 142:104973 (2020)
DOI:10.1016/j.nbd.2020.104973
Reference
PMID:18245809
  Authors
Kovacs GG, Budka H
  Title
Prion diseases: from protein to cell pathology.
  Journal
Am J Pathol 172:555-65 (2008)
DOI:10.2353/ajpath.2008.070442
Reference
PMID:15695097
  Authors
Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
  Journal
Trends Cell Biol 15:102-11 (2005)
DOI:10.1016/j.tcb.2004.12.002
Reference
PMID:17051207
  Authors
Caughey B, Baron GS
  Title
Prions and their partners in crime.
  Journal
Nature 443:803-10 (2006)
DOI:10.1038/nature05294
Reference
PMID:11592845
  Authors
Chiesa R, Harris DA
  Title
Prion diseases: what is the neurotoxic molecule?
  Journal
Neurobiol Dis 8:743-63 (2001)
DOI:10.1006/nbdi.2001.0433
Reference
PMID:17085779
  Authors
Fasano C, Campana V, Zurzolo C
  Title
Prions: protein only or something more? Overview of potential prion cofactors.
  Journal
J Mol Neurosci 29:195-214 (2006)
DOI:10.1385/JMN:29:3:195
Reference
PMID:14705136
  Authors
Roucou X, Gains M, LeBlanc AC
  Title
Neuroprotective functions of prion protein.
  Journal
J Neurosci Res 75:153-61 (2004)
DOI:10.1002/jnr.10864
Reference
PMID:10398674
  Authors
Harris DA
  Title
Cellular biology of prion diseases.
  Journal
Clin Microbiol Rev 12:429-44 (1999)
Reference
PMID:15890824
  Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
  Title
Prion biology relevant to bovine spongiform encephalopathy.
  Journal
J Anim Sci 83:1455-76 (2005)
DOI:10.2527/2005.8361455x
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
  Journal
Biochem Biophys Res Commun 483:1148-1155 (2017)
DOI:10.1016/j.bbrc.2016.07.118
Reference
PMID:31618844
  Authors
Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
Prion Protein in Glioblastoma Multiforme.
  Journal
Int J Mol Sci 20:E5107 (2019)
DOI:10.3390/ijms20205107
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:30710214
  Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
  Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
  Journal
Mol Neurobiol 56:6035-6045 (2019)
DOI:10.1007/s12035-019-1505-6
Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
  Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
DOI:10.1093/abbs/gmt014
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:29194372
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
  Journal
Pathogens 6:E63 (2017)
DOI:10.3390/pathogens6040063
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:18420416
  Authors
Ferreiro E, Oliveira CR, Pereira CM
  Title
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
  Journal
Neurobiol Dis 30:331-42 (2008)
DOI:10.1016/j.nbd.2008.02.003
Reference
PMID:16844381
  Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
  Title
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
  Journal
Neurobiol Dis 23:669-78 (2006)
DOI:10.1016/j.nbd.2006.05.011
Reference
PMID:21980554
  Authors
Torres M, Encina G, Soto C, Hetz C
  Title
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
  Journal
Commun Integr Biol 4:258-61 (2011)
DOI:10.4161/cib.4.3.15019
Reference
PMID:25766616
  Authors
Ciechanover A, Kwon YT
  Title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
  Journal
Exp Mol Med 47:e147 (2015)
DOI:10.1038/emm.2014.117
Reference
PMID:17466621
  Authors
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ
  Title
Disease-associated prion protein oligomers inhibit the 26S proteasome.
  Journal
Mol Cell 26:175-88 (2007)
DOI:10.1016/j.molcel.2007.04.001
Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
  Title
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
  Journal
Science 284:339-43 (1999)
DOI:10.1126/science.284.5412.339
Reference
PMID:14532116
  Authors
Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
  Title
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
  Journal
EMBO J 22:5435-45 (2003)
DOI:10.1093/emboj/cdg537
Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
  Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
  Journal
Front Cell Neurosci 13:350 (2019)
DOI:10.3389/fncel.2019.00350
Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
Reference
PMID:21196165
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
Reference
PMID:23479001
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
  Journal
Cell Mol Biol Lett 18:209-30 (2013)
DOI:10.2478/s11658-013-0085-0
Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
  Journal
Front Aging Neurosci 9:120 (2017)
DOI:10.3389/fnagi.2017.00120
Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
DOI:10.1074/jbc.M410966200
Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
DOI:10.1073/pnas.0408612101
Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
DOI:10.1186/1750-1326-5-6
Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
DOI:10.1007/s12035-018-1193-7
Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
ecb00190  Oxidative phosphorylation
ecb03050  Proteasome
ecb04020  Calcium signaling pathway
ecb04140  Autophagy - animal
ecb04141  Protein processing in endoplasmic reticulum
ecb04142  Lysosome
ecb04144  Endocytosis
ecb04210  Apoptosis
ecb04330  Notch signaling pathway
ecb04610  Complement and coagulation cascades
ecb04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

DBGET integrated database retrieval system