Entry Name NOD-like receptor signaling pathway - Hemiscyllium ocellatum (epaulette shark)
Description Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map hoc04621 NOD-like receptor signaling pathway
Organism Hemiscyllium ocellatum (epaulette shark) [GN:
hoc ]
Gene 132805786 gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622 ]
132815068 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
132817675 trpm2; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 2 [KO:K04977 ] [EC:3.6.1.13 ]
132817881 nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734 ]
132819859 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
132820485 brcc3; lys-63-specific deubiquitinase isoform X1 [KO:K11864 ] [EC:3.4.19.-]
132821030 tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
132823437 vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
132823672 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
132823931 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
132825953 card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
132826793 itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
132828404 itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
132830513 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630 ]
132831144 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
132832250 nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
132834324 trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982 ] [EC:2.7.11.1 ]
132835111 vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
132837033 vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Vandenabeele P, Bertrand MJ
Title The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
Journal Reference Authors Strober W, Murray PJ, Kitani A, Watanabe T
Title Signalling pathways and molecular interactions of NOD1 and NOD2.
Journal Reference Authors Estornes Y, Bertrand MJ
Title IAPs, regulators of innate immunity and inflammation.
Journal Reference Authors Jakopin Z
Title Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
Journal Reference Authors Caruso R, Warner N, Inohara N, Nunez G
Title NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Journal Reference Authors Murray PJ
Title Beyond peptidoglycan for Nod2.
Journal Reference Authors Lecat A, Piette J, Legrand-Poels S
Title The protein Nod2: an innate receptor more complex than previously assumed.
Journal Reference Authors Man SM, Kanneganti TD
Title Converging roles of caspases in inflammasome activation, cell death and innate immunity.
Journal Reference Authors Broz P, Dixit VM
Title Inflammasomes: mechanism of assembly, regulation and signalling.
Journal Reference Authors Man SM, Kanneganti TD
Title Regulation of inflammasome activation.
Journal Reference Authors Jo EK, Kim JK, Shin DM, Sasakawa C
Title Molecular mechanisms regulating NLRP3 inflammasome activation.
Journal Reference Authors Broz P, Monack DM
Title Newly described pattern recognition receptors team up against intracellular pathogens.
Journal Reference Authors Rathinam VA, Vanaja SK, Fitzgerald KA
Title Regulation of inflammasome signaling.
Journal Reference Authors Sutterwala FS, Haasken S, Cassel SL
Title Mechanism of NLRP3 inflammasome activation.
Journal Reference Authors Latz E, Xiao TS, Stutz A
Title Activation and regulation of the inflammasomes.
Journal Reference Authors Blander JM
Title A long-awaited merger of the pathways mediating host defence and programmed cell death.
Journal Reference Authors von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
Title Recognition of bacteria by inflammasomes.
Journal Reference Authors Abais JM, Xia M, Zhang Y, Boini KM, Li PL
Title Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
Journal Reference Authors Storek KM, Monack DM
Title Bacterial recognition pathways that lead to inflammasome activation.
Journal Reference Authors Hu H, Sun SC
Title Ubiquitin signaling in immune responses.
Journal Reference Authors Guo H, Callaway JB, Ting JP
Title Inflammasomes: mechanism of action, role in disease, and therapeutics.
Journal Reference Authors Man SM, Kanneganti TD
Title Gasdermin D: the long-awaited executioner of pyroptosis.
Journal Reference Authors Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Title TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Journal Reference Authors Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
Title IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
Journal Reference Authors Heilig R, Broz P
Title Function and mechanism of the pyrin inflammasome.
Journal Reference Authors Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
Title RNase L activates the NLRP3 inflammasome during viral infections.
Journal Related hoc04620 Toll-like receptor signaling pathway
KO pathway
