KEGG   PATHWAY: ipu04150
Entry
ipu04150                    Pathway                                
Name
mTOR signaling pathway - Ictalurus punctatus (channel catfish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ipu04150  mTOR signaling pathway
ipu04150

Organism
Ictalurus punctatus (channel catfish) [GN:ipu]
Gene
108269294  large neutral amino acids transporter small subunit 1 [KO:K13780]
108279203  slc3a2b; solute carrier family 3 member 2b [KO:K06519]
108267557  4F2 cell-surface antigen heavy chain [KO:K06519]
108277090  sodium-coupled neutral amino acid transporter 9 [KO:K14995]
108256618  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
108270233  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
108277294  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
108273274  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
108256700  atp6v1c1a; V-type proton ATPase subunit C 1-A isoform X1 [KO:K02148]
108269976  V-type proton ATPase subunit C 1-B [KO:K02148]
100528211  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
100528265  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
108269194  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
108279552  V-type proton ATPase subunit F [KO:K02151]
108259956  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100304945  V-type proton ATPase subunit H isoform X1 [KO:K02144]
108277928  ragulator complex protein LAMTOR1 [KO:K20397]
108256197  ragulator complex protein LAMTOR2 [KO:K20398]
100529030  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
108279553  ragulator complex protein LAMTOR4 [KO:K20399]
100528355  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
108266904  folliculin [KO:K09594]
108278774  folliculin-interacting protein 1 isoform X1 [KO:K20400]
108260744  fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
108268916  rraga; ras-related GTP-binding protein A [KO:K16185]
108275365  rragcb; ras-related GTP binding Cb [KO:K16186]
108270433  rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
100528436  rragca; ras-related GTP binding Ca [KO:K16186]
108257059  sesn2; sestrin-2 isoform X1 [KO:K20394]
108255989  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
108260111  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
108256637  GATOR complex protein MIOS [KO:K20407]
108257312  nucleoporin SEH1 isoform X1 [KO:K14299]
108264580  GATOR complex protein WDR24 isoform X1 [KO:K20408]
124626002  GATOR complex protein WDR59 isoform X4 [KO:K20409]
100528323  sec13; protein SEC13 homolog [KO:K14004]
108277033  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
108271895  GATOR complex protein NPRL2 isoform X1 [KO:K20405]
108257124  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
108279378  S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
108280931  E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
108272627  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
108280807  uncharacterized protein LOC108280807 isoform X1 [KO:K16184]
108265039  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108267067  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
108274161  target of rapamycin complex subunit lst8 [KO:K08266]
108263099  telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
108276140  TELO2-interacting protein 1 homolog [KO:K20403]
108276728  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
108255811  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
108273075  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
108264732  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
108275291  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
108271928  zgc:123305 isoform X2 [KO:K15728] [EC:3.1.3.4]
108268131  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
108270137  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
108279004  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108265551  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
108277484  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
108279290  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108276381  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
108260188  eif4e1b; eukaryotic translation initiation factor 4E-1B isoform X2 [KO:K03259]
108263665  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
100528371  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
108269089  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X2 [KO:K03259]
108261064  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108260512  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
108278249  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
108272209  eif4bb; eukaryotic translation initiation factor 4Bb isoform X1 [KO:K03258]
108276111  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
100304560  rps6; 40S ribosomal protein S6 [KO:K02991]
108259502  STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
108271608  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
108280802  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
108268960  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
100528152  cab39l; calcium-binding protein 39-like [KO:K08272]
108260283  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
108258037  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
108255875  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
108279310  tsc1b; TSC complex subunit 1b [KO:K07206]
108258582  tuberin isoform X1 [KO:K07207]
108260306  tbc1d7; TBC1 domain family member 7 [KO:K20396]
100528708  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
108271576  GTP-binding protein Rheb [KO:K07208]
108263660  DNA damage-inducible transcript 4 protein [KO:K08270]
108274112  DNA damage-inducible transcript 4 protein [KO:K08270]
108276209  protein Wnt-1 [KO:K03209]
108263957  protein Wnt-2 [KO:K00182]
108271793  wnt2ba; wingless-type MMTV integration site family, member 2Ba isoform X1 [KO:K00182]
108266047  wnt2bb; wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
108267526  protein Wnt-3a [KO:K00312]
108273758  wnt3; proto-oncogene Wnt-3 [KO:K00312]
108263562  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
108255178  protein Wnt-4a isoform X1 [KO:K00408]
108279752  wnt5b; protein Wnt-5b [KO:K00444]
108265003  protein Wnt-5a [KO:K00444]
108266110  wnt6b; protein Wnt-6 isoform X1 [KO:K00445]
108273177  wnt6a; protein Wnt-6 isoform X1 [KO:K00445]
108275429  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
108276349  protein Wnt-7a [KO:K00572]
108280000  wnt7ba; protein Wnt-7b [KO:K00572]
108255289  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
108268464  protein Wnt-8a isoform X1 [KO:K00714]
108268465  protein Wnt-8a isoform X1 [KO:K00714]
108262937  protein Wnt-8b [KO:K00714]
108267524  protein Wnt-9a [KO:K01064]
108259511  wnt9b; protein Wnt-9b [KO:K01064]
108266076  protein Wnt-10a [KO:K01357]
108276208  wnt10b; protein Wnt-10b [KO:K01357]
108259816  wnt11f2; protein Wnt-11 isoform X1 [KO:K01384]
108277378  protein Wnt-11 [KO:K01384]
128632699  protein Wnt-11-like isoform X1 [KO:K01384]
108279512  protein Wnt-16 [KO:K01558]
108273289  fzd7b; frizzled-7b [KO:K02432]
108267025  fzd7a; frizzled-7a [KO:K02432]
108259097  frizzled-2 [KO:K02235]
108257739  fzd3a; frizzled-3a isoform X1 [KO:K02329]
108270052  fzd3b; frizzled-3b isoform X1 [KO:K02329]
108277754  frizzled-4 [KO:K02354]
108266738  frizzled-5 [KO:K02375]
108272300  fzd8a; frizzled-8a [KO:K02375]
108256595  frizzled-6 [KO:K02376]
108260460  fzd9a; frizzled-9 [KO:K02842]
108266036  fzd10; frizzled-10 [KO:K02842]
108263895  fzd9b; frizzled-9b [KO:K02842]
108268658  low-density lipoprotein receptor-related protein 5 [KO:K03068]
108279868  low-density lipoprotein receptor-related protein 6 [KO:K03068]
108268006  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
108264349  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
108268205  segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
108276110  dvl1a; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
108258646  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b isoform X1 [KO:K03083] [EC:2.7.11.26]
108266408  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100304592  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
108276487  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108268297  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108265675  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108259964  insulin [KO:K04526]
108259786  insulin [KO:K04526]
108280599  insulin [KO:K04526]
100305062  igf1; insulin-like growth factor I precursor [KO:K05459]
108267827  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
108271091  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
100304999  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
108256494  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
100528114  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
108270875  son of sevenless homolog 1 isoform X1 [KO:K03099]
108263000  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
128631210  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100528230  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
108259582  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
108258948  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
108274959  kras; GTPase KRas isoform X2 [KO:K07827]
100305071  GTPase NRas [KO:K07828]
108279928  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108276324  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X5 [KO:K04366] [EC:2.7.11.1]
108255012  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124627985  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100528123  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
108271291  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
108255782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108256206  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108270094  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
108260206  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
108269104  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108256425  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
108263555  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
108278298  insulin receptor substrate 1-B isoform X1 [KO:K16172]
108267519  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
108272037  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
108260231  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108275608  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108276156  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108280664  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108271155  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108269686  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108273661  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108257355  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
108264442  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
108263416  akt3a; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108264340  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108269621  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108259077  akt3b; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108263650  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108260242  target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
108278965  rictorb; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
108268783  prr5a; proline-rich protein 5a isoform X1 [KO:K20411]
108279541  proline-rich protein 5 isoform X2 [KO:K20411]
108259205  proline-rich protein 5-like isoform X1 [KO:K20411]
108274418  proline-rich protein 5-like isoform X1 [KO:K20411]
108271788  rhoca; ras homolog family member Ca [KO:K04513]
108275781  rhoac; rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
108265463  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
108254710  transforming protein RhoA [KO:K04513]
108265880  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
100528424  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
108259727  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108273127  prkcaa; protein kinase C, alpha, a isoform X2 [KO:K02677] [EC:2.7.11.13]
108258960  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
108260780  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108266582  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108276211  serine/threonine-protein kinase Sgk1 isoform X4 [KO:K13302] [EC:2.7.11.1]
108273319  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
108256136  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ipu00561  Glycerolipid metabolism
ipu04010  MAPK signaling pathway
ipu04140  Autophagy - animal
ipu04810  Regulation of actin cytoskeleton
ipu04910  Insulin signaling pathway
KO pathway
ko04150   
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