KEGG   PATHWAY: lcf04068
Entry
lcf04068                    Pathway                                
Name
FoxO signaling pathway - Lates calcarifer (barramundi perch)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
lcf04068  FoxO signaling pathway
lcf04068

Other DBs
GO: 0009267
Organism
Lates calcarifer (barramundi perch) [GN:lcf]
Gene
108876160  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
108886089  transforming growth factor beta-2 proprotein [KO:K13376]
108872574  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
108895683  transforming growth factor beta-3 proprotein [KO:K13377]
108892510  transforming growth factor beta-3 proprotein [KO:K13377]
108898453  LOW QUALITY PROTEIN: TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
108889085  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108881978  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108876301  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108888967  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
108878621  mothers against decapentaplegic homolog 4 [KO:K04501]
108884647  mothers against decapentaplegic homolog 4 [KO:K04501]
108896340  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
108886506  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
108887878  smad3a; mothers against decapentaplegic homolog 3 [KO:K23605]
108883583  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
108874097  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
108879064  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108883567  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108878615  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
108880315  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
108872967  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
108883443  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
108881469  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
108872825  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X2 [KO:K07200]
108892803  uncharacterized protein LOC108892803 [KO:K07200]
108890113  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
108877931  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
108899896  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
108900731  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
108895890  E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
108875518  histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
108877577  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108889106  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108886160  crebbpb; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108885407  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108886237  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
108881085  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
108879977  LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
108888287  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108873059  mapk8b; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
108874078  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108899231  LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
108901469  serine/threonine-protein kinase 4 [KO:K04411]
108897582  insulin-like growth factor I [KO:K05459]
108900498  igf3; insulin-like growth factor 3 isoform X1 [KO:K05459]
108897720  igf1rb; insulin-like growth factor 1b receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
108875244  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108882783  insulin-like [KO:K04526]
108890171  insulin [KO:K04526]
108893384  insulin-like [KO:K04526]
108890250  insulin [KO:K04526]
108884165  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
108881334  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
108897056  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
108899730  irs2b; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
108902081  insulin receptor substrate 2-B [KO:K07187]
108900631  insulin receptor substrate 2 isoform X1 [KO:K07187]
108876542  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108892325  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108883763  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108888220  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108882207  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
108880106  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108883804  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
108883666  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108895428  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108891083  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
108902763  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108875232  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
108886759  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
108891107  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108892003  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
108881598  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108891507  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108897292  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108882522  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108898795  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108892520  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108893445  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108897414  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108889640  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
108899469  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
108896848  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
108891669  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
108881792  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
108893933  forkhead box protein O1-A [KO:K07201]
108876119  foxo1a; forkhead box protein O1-A [KO:K07201]
108880906  foxo3b; forkhead box protein O3B [KO:K09408]
108902036  foxo3a; forkhead box protein O3a [KO:K09408]
108900294  LOW QUALITY PROTEIN: forkhead box protein O6b [KO:K09408]
108872571  foxo4; forkhead box protein O6 [KO:K12358]
108898544  forkhead box protein O3-like [KO:K17847]
108880909  LOW QUALITY PROTEIN: metabotropic glutamate receptor 1 [KO:K04603]
108902017  LOW QUALITY PROTEIN: metabotropic glutamate receptor 1b [KO:K04603]
108878151  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
108883655  homer protein homolog 3 isoform X1 [KO:K15010]
108887932  homer protein homolog 2 isoform X1 [KO:K15010]
108902769  homer protein homolog 3 [KO:K15010]
108895453  homer protein homolog 1 isoform X3 [KO:K15010]
108898966  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K17848]
108883001  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
108877565  casein kinase I [KO:K08960] [EC:2.7.11.1]
108889126  csnk1e; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
108897837  interleukin-6 [KO:K05405]
108890002  interleukin-10 [KO:K05443]
108901193  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108885177  LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
108894667  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
108883329  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
108898666  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
108886692  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
108882268  son of sevenless homolog 1 isoform X2 [KO:K03099]
108875409  GTPase HRas [KO:K02833]
108875379  GTPase KRas isoform X1 [KO:K07827]
108881007  zgc:55558; GTPase KRas [KO:K07827]
108897545  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108900163  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
108878154  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
108886445  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108877315  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
108883596  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X2 [KO:K04369] [EC:2.7.12.2]
108881026  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108891348  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108901376  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
108875352  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108901401  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108882620  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108876452  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
108884069  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
108882672  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
108898963  LOW QUALITY PROTEIN: cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
108886434  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
108898499  protein arginine N-methyltransferase 1 isoform X2 [KO:K11434] [EC:2.1.1.319]
108881173  foxg1a; forkhead box protein G1 [KO:K09385]
108879393  forkhead box protein G1c [KO:K09385]
108872909  forkhead box protein G1b [KO:K09385]
108889030  G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
108894316  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
108894246  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
108898800  ccnp; cyclin N-terminal domain-containing protein 2 [KO:K21770]
108902096  G2/mitotic-specific cyclin-B3 [KO:K21771]
108884596  G1/S-specific cyclin-D1 [KO:K04503]
108877824  G1/S-specific cyclin-D1 [KO:K04503]
108879779  G1/S-specific cyclin-D1 [KO:K04503]
108886219  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
108901859  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
108880592  cyclin Dx [KO:K10151]
108897225  ccng2; cyclin-G2 [KO:K10146]
108876993  LOW QUALITY PROTEIN: cyclin-G2-like [KO:K10146]
108896541  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
108875868  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
108886473  LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
108890605  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
108890602  cdkn1ba; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108883075  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
108885228  LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
108894767  LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
108878162  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
108883487  serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
108892537  serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
108882519  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
108891774  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108874969  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108883699  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
108878958  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
108901136  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
108901137  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
108872556  cd40lg; CD40 ligand [KO:K04389]
108879004  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108896263  bcl-2-like protein 11 isoform X2 [KO:K16341]
108885067  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108875098  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108878871  LOW QUALITY PROTEIN: BCL6A transcription repressor a [KO:K15618]
108883741  bcl6ab; BCL6A transcription repressor b [KO:K15618]
108897318  bnip4; BCL2 interacting protein 4 [KO:K15464]
108874129  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
108887314  ubiquitin-like protein ATG12 [KO:K08336]
108880006  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
108894307  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108901949  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
108887330  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
108883043  catalase [KO:K03781] [EC:1.11.1.6]
108883098  superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
108873779  LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108889731  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
108898233  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
108884388  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
108885148  g6pc1a.2; LOW QUALITY PROTEIN: glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108885149  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108888663  glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
108886652  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108886653  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108876681  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
108897830  glucose-6-phosphatase catalytic subunit 1-like isoform X2 [KO:K01084] [EC:3.1.3.9]
108886648  LOW QUALITY PROTEIN: glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
108892301  interleukin-7 receptor subunit alpha [KO:K05072]
108875542  interleukin-7 receptor subunit alpha [KO:K05072]
108884182  klf2b; Krueppel-like factor 2b [KO:K17845]
108896958  Krueppel-like factor 2 [KO:K17845]
108874189  sphingosine 1-phosphate receptor 1 [KO:K04288]
108881338  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
108875106  V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
108875221  LOW QUALITY PROTEIN: V(D)J recombination-activating protein 2 [KO:K10988]
108888649  F-box only protein 32 [KO:K10305]
108895653  F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
lcf00010  Glycolysis / Gluconeogenesis
lcf00020  Citrate cycle (TCA cycle)
lcf00190  Oxidative phosphorylation
lcf04010  MAPK signaling pathway
lcf04110  Cell cycle
lcf04120  Ubiquitin mediated proteolysis
lcf04140  Autophagy - animal
lcf04210  Apoptosis
lcf04350  TGF-beta signaling pathway
lcf04910  Insulin signaling pathway
KO pathway
ko04068   
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