KEGG   PATHWAY: lruf04360
Entry
lruf04360                   Pathway                                
Name
Axon guidance - Lynx rufus (bobcat)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
lruf04360  Axon guidance
lruf04360

Other DBs
GO: 0007411
Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124516061  netrin-G1 isoform X1 [KO:K07522]
124525650  netrin-G2 [KO:K16359]
124504657  leucine-rich repeat-containing protein 4C [KO:K07523]
124523062  leucine-rich repeat-containing protein 4 [KO:K16351]
124519652  netrin-1 [KO:K06843]
124525481  netrin-3 [KO:K06844]
124502291  netrin-4 isoform X1 [KO:K06845]
124517028  netrin receptor DCC [KO:K06765]
124503060  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
124511524  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
124526885  short transient receptor potential channel 1 isoform X1 [KO:K04964]
124520921  short transient receptor potential channel 3 isoform X1 [KO:K04966]
124510242  short transient receptor potential channel 4 isoform X1 [KO:K04967]
124514012  short transient receptor potential channel 5 [KO:K04968]
124504816  short transient receptor potential channel 6 isoform X1 [KO:K04969]
124519949  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
124521006  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124506908  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124504103  calcineurin subunit B type 1 [KO:K06268]
124502506  calcineurin subunit B type 2 [KO:K06268]
124502945  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
124511421  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
124508199  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
124507840  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124528746  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
124504000  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
124519305  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
124501030  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
124522479  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
124519312  cell division control protein 42 homolog [KO:K04393]
124514573  cell division control protein 42 homolog [KO:K04393]
124520429  actin-binding LIM protein 2 [KO:K07520]
124507157  actin-binding LIM protein 1 isoform X1 [KO:K07520]
124507294  actin-binding LIM protein 3 [KO:K07520]
124526140  cytoplasmic protein NCK1 [KO:K07365]
124504646  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124526056  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
124513933  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
124511141  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
124504252  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
124508097  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
124523904  transforming protein RhoA [KO:K04513]
124517572  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124504219  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
124505936  netrin receptor UNC5B isoform X1 [KO:K07521]
124520484  netrin receptor UNC5C isoform X1 [KO:K07521]
124520947  netrin receptor UNC5D [KO:K07521]
124506753  netrin receptor UNC5A [KO:K07521]
124518188  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
124514429  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
124517399  repulsive guidance molecule A [KO:K23096]
124508026  neogenin isoform X1 [KO:K06766]
124522618  myosin light chain 5 [KO:K12753]
124503723  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
124517541  myosin regulatory light chain 12B [KO:K12757]
124517599  myosin regulatory light polypeptide 9 [KO:K12757]
124504834  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
124514888  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
124506715  ephrin-A5 [KO:K05462]
124521669  ephrin-A3 [KO:K05462]
124521678  ephrin-A4-like [KO:K05462]
124521778  ephrin-A1 isoform X1 [KO:K05462]
124519651  ephrin-B3 [KO:K05463]
124521607  ephrin-B1 [KO:K05463]
124516390  ephrin-B2 [KO:K05463]
124524200  ephrin type-A receptor 1 [KO:K05102] [EC:2.7.10.1]
124516323  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
124526474  ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
124515388  ephrin type-A receptor 4 [KO:K05105] [EC:2.7.10.1]
124520477  ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
124526536  ephrin type-A receptor 6 isoform X1 [KO:K05107] [EC:2.7.10.1]
124528634  ephrin type-A receptor 7 isoform X1 [KO:K05108] [EC:2.7.10.1]
124515485  LOW QUALITY PROTEIN: ephrin type-A receptor 8-like [KO:K05109] [EC:2.7.10.1]
124527129  ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
124514391  LOW QUALITY PROTEIN: ephrin type-B receptor 2-like [KO:K05111] [EC:2.7.10.1]
124526513  ephrin type-B receptor 3 [KO:K05112] [EC:2.7.10.1]
124519179  ephrin type-B receptor 4 [KO:K05113] [EC:2.7.10.1]
124523952  ephrin type-B receptor 6 isoform X1 [KO:K05114] [EC:2.7.10.1]
124525633  tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
124510307  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
124518790  ras GTPase-activating protein 1 [KO:K04352]
124516544  ephexin-1 isoform X1 [KO:K07525]
124527565  GTPase HRas isoform X1 [KO:K02833]
124502703  GTPase KRas isoform X1 [KO:K07827]
124516245  GTPase NRas [KO:K07828]
124517731  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
124519861  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124504320  cytoplasmic protein NCK2 [KO:K19862]
124503316  regulator of G-protein signaling 3-like isoform X1 [KO:K07524]
124506687  stromal cell-derived factor 1 isoform X1 [KO:K10031]
124515642  C-X-C chemokine receptor type 4 [KO:K04189]
124514443  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124523010  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124524167  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
124507026  slit homolog 1 protein [KO:K06838]
124520495  slit homolog 2 protein [KO:K06839]
124520428  slit homolog 3 protein isoform X1 [KO:K06850]
124527273  roundabout homolog 1 [KO:K06753]
124527274  roundabout homolog 2 [KO:K06754]
124505884  roundabout homolog 3 [KO:K06755]
124501814  SLIT-ROBO Rho GTPase-activating protein 1 [KO:K07526]
124509966  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
124524089  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526]
124524325  semaphorin-3F isoform X1 [KO:K06840]
124524563  semaphorin-3A [KO:K06840]
124524686  semaphorin-3D [KO:K06840]
124524707  semaphorin-3E [KO:K06840]
124524924  semaphorin-3C [KO:K06840]
124524979  semaphorin-3G [KO:K06840]
124523742  semaphorin-3B [KO:K06840]
124524674  plexin-A1 [KO:K06820]
124525844  plexin-A3 [KO:K06820]
124523477  plexin-A4 [KO:K06820]
124502191  neuropilin-1 isoform X1 [KO:K06724]
124525880  neural cell adhesion molecule L1 isoform X1 [KO:K06550]
124519234  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
124518218  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
124510444  LOW QUALITY PROTEIN: cofilin-1-like [KO:K05765]
124505490  cofilin-1 [KO:K05765]
124508900  cofilin-2 [KO:K05765]
124505621  rho-related GTP-binding protein RhoD [KO:K07530]
124501890  rho-related GTP-binding protein Rho6 [KO:K07531]
124517366  tyrosine-protein kinase Fes/Fps isoform X1 [KO:K07527] [EC:2.7.10.2]
124504179  dihydropyrimidinase-related protein 5 [KO:K07529]
124520502  dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528]
124523528  cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
124526728  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124517332  semaphorin-4B [KO:K06521]
124503780  semaphorin-4F isoform X1 [KO:K06521]
124504224  semaphorin-4C [KO:K06521]
124527698  LOW QUALITY PROTEIN: semaphorin-4D-like [KO:K06521]
124507068  semaphorin-4G [KO:K06521]
124521709  semaphorin-4A-like isoform X1 [KO:K06521]
124526819  semaphorin-5B isoform X1 [KO:K06841]
124508024  semaphorin-5A [KO:K06841]
124524921  semaphorin-6B [KO:K06842]
124521799  semaphorin-6A [KO:K06842]
124508062  semaphorin-6D isoform X1 [KO:K06842]
124515391  semaphorin-6C [KO:K06842]
124525857  plexin-B3 isoform X1 [KO:K06821]
124502237  plexin-B2 [KO:K06821]
124524122  plexin-B1 [KO:K06821]
124524670  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
124523760  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124510904  ras-related protein R-Ras isoform X1 [KO:K07829]
124508417  semaphorin-7A [KO:K06529]
124501121  LOW QUALITY PROTEIN: plexin-C1-like [KO:K06572]
124501220  integrin beta-1 [KO:K05719]
124523508  sonic hedgehog protein [KO:K11988]
124529241  protein patched homolog 1 [KO:K06225]
124525159  smoothened homolog [KO:K06226]
124513500  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124505228  integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
124527605  LOW QUALITY PROTEIN: olfactory receptor 1I1-like [KO:K06272] [EC:2.7.11.1]
124527608  LOW QUALITY PROTEIN: olfactory receptor 1I1-like [KO:K06272] [EC:2.7.11.1]
124527611  LOW QUALITY PROTEIN: olfactory receptor 1I1-like [KO:K06272] [EC:2.7.11.1]
124527232  brother of CDO [KO:K20020]
124524797  protein Wnt-5a [KO:K00444]
124502605  protein Wnt-5b [KO:K00444]
124520701  frizzled-3 [KO:K02329]
124526855  tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
124524655  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
124520612  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124506916  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124521364  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
124514394  protein Wnt-4 [KO:K00408]
124525968  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124527077  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124514827  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124517840  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124514527  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
124523730  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124517688  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
124501833  partitioning defective 3 homolog [KO:K04237]
124516243  protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
124504012  partitioning defective 6 homolog beta [KO:K06093]
124511405  partitioning defective 6 homolog alpha [KO:K06093]
124517013  partitioning defective 6 homolog gamma-like isoform X1 [KO:K06093]
124518280  protein phosphatase Slingshot homolog 1-like isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124505355  protein phosphatase Slingshot homolog 3-like isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124513000  protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124504146  bone morphogenetic protein 7 [KO:K16621]
124503099  growth/differentiation factor 7-like [KO:K20013]
124516263  bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
124520615  bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
lruf04010  MAPK signaling pathway
lruf04060  Cytokine-cytokine receptor interaction
lruf04310  Wnt signaling pathway
lruf04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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