KEGG   PATHWAY: lsr04148
Entry
lsr04148                    Pathway                                
Name
Efferocytosis - Lonchura striata domestica (Bengalese finch)
Class
Cellular Processes; Transport and catabolism
Pathway map
lsr04148  Efferocytosis
lsr04148

Organism
Lonchura striata domestica (Bengalese finch) [GN:lsr]
Gene
110477516  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
110468271  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
110478402  PANX1; pannexin-1 [KO:K03443]
110481488  P2RY2; P2Y purinoceptor 2 [KO:K04269]
110481473  P2RY6; P2Y purinoceptor 6 [KO:K04272]
110478353  P2RY12; P2Y purinoceptor 12 [KO:K04298]
110476572  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
110477493  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
110483821  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110472799  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
110475771  ABCA7; phospholipid-transporting ATPase ABCA7 [KO:K05641]
110484102  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
110467958  ADAM17; LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
110471419  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
110476305  mucin-5AC [KO:K05508]
110471061  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
110472386  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
110483466  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
110473033  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110484111  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
110476822  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
110471247  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
110481332  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110475229  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
110470665  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
110477629  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110474302  MFGE8; lactadherin isoform X1 [KO:K17253]
110478767  GAS6; growth arrest-specific protein 6 [KO:K05464]
110474325  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
110469764  CD36; platelet glycoprotein 4 [KO:K06259]
110475265  THBS1; thrombospondin-1 [KO:K16857]
110482957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110478470  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110467832  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110474759  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
110482684  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
110475023  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110482796  transforming growth factor beta-1 proprotein-like [KO:K13375]
110471764  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
110480028  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
110481980  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110471178  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110482768  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
110480733  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
110478273  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
110473464  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110473465  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110484504  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110484512  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110473090  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110475663  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
110472949  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110468265  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110472205  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110468662  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110471701  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110479856  ANO6; anoctamin-6 isoform X1 [KO:K19500]
110475135  ANO3; LOW QUALITY PROTEIN: anoctamin-3 [KO:K19498]
110483123  ANO4; anoctamin-4 isoform X1 [KO:K19499]
110469623  ANO5; anoctamin-5 isoform X1 [KO:K19480]
110485051  ANO9; anoctamin-9 [KO:K19503]
110475758  BSG; basigin isoform X1 [KO:K06535]
110484295  XKR8; XK-related protein 8 [KO:K26813]
110477538  XKR9; LOW QUALITY PROTEIN: XK-related protein 9 [KO:K26814]
110469017  XKR7; XK-related protein 7 [KO:K26811]
110484764  XKR4; XK-related protein 4 [KO:K26811]
110475994  XKR6; XK-related protein 6 [KO:K26811]
110482587  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
110470761  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
110469598  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
110477612  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
110478762  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
110483668  TMEM30A; cell cycle control protein 50A [KO:K26935]
110481515  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
110476177  ITGAV; integrin alpha-V [KO:K06487]
110476970  ITGB3; integrin beta-3 [KO:K06493]
110468285  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
110472106  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
110471396  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
110482731  T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
110472239  STAB1; stabilin-1 [KO:K19020]
110473791  STAB2; stabilin-2 [KO:K19013]
110471669  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110472998  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
110481994  CRK; adapter molecule crk isoform X1 [KO:K04438]
110481320  CRKL; crk-like protein [KO:K04438]
110483393  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
110468444  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
110475527  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110468450  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
110473400  disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
110481627  CALR; calreticulin [KO:K08057]
110472263  C1QA; complement C1q subcomponent subunit A [KO:K03986]
110472265  C1QB; complement C1q subcomponent subunit B [KO:K03987]
110472264  C1QC; complement C1q subcomponent subunit C isoform X2 [KO:K03988]
110477095  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
110482521  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
110483012  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
110481962  SCARF1; scavenger receptor class F member 1 [KO:K24318]
110476178  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
110473500  RAB17; ras-related protein Rab-17 [KO:K07909]
110474606  RAB5A; ras-related protein Rab-5A [KO:K07887]
116184544  RAB5B; ras-related protein Rab-5B [KO:K07888]
110471846  RAB5C; ras-related protein Rab-5C [KO:K07889]
110474621  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
110474071  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
110470437  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
110468725  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
110472091  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
110478155  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
110477653  RAB14; ras-related protein Rab-14 [KO:K07881]
110472116  VPS39; vam6/Vps39-like protein [KO:K20183]
110479369  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
110471531  RAB7A; ras-related protein Rab-7a [KO:K07897]
110473080  RAB7B; LOW QUALITY PROTEIN: ras-related protein Rab-7b [KO:K07898]
110472257  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
110473997  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
110467950  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
110475749  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
110472063  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
110484466  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
110479260  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
110475983  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
110469870  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
110478966  PBX1; pre-B-cell leukemia transcription factor 1 [KO:K09355]
110473089  IL10; interleukin-10 [KO:K05443]
110475305  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X2 [KO:K01052] [EC:3.1.1.13]
110474006  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
110474008  putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
110473020  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
110473454  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
110474449  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
110475406  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
110476052  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
110477031  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
110483690  CD24; signal transducer CD24 [KO:K06469]
110474226  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
110468975  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
110480841  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
110478178  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
lsr00010  Glycolysis / Gluconeogenesis
lsr04140  Autophagy - animal
lsr04145  Phagosome
KO pathway
ko04148   
LinkDB

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