KEGG   PATHWAY: lve05208
Entry
lve05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Lipotes vexillifer (Yangtze River dolphin)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
lve05208  Chemical carcinogenesis - reactive oxygen species
lve05208

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103071271  AS3MT; LOW QUALITY PROTEIN: arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
103076713  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103081051  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103078333  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
103078618  GSTM1; LOW QUALITY PROTEIN: glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
103081925  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103082472  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103087449  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
103087887  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103085403  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
103085685  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
103071326  MGST2; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103082194  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
3802087  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3802093  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3802099  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3802089  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3802088  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3802090  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
103085270  NADH-ubiquinone oxidoreductase chain 6-like [KO:K03884] [EC:7.1.1.2]
3802091  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103069803  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
103077470  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
103082014  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
103091475  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
103078685  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103085823  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103072179  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103071324  NDUFA4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [KO:K03948]
103083475  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103071560  NDUFA6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103070385  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
103091533  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
103076341  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103079926  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103089500  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103078571  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103072085  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
103073963  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103087083  uncharacterized protein LOC103087083 [KO:K03957]
103078980  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103076071  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103072640  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103082087  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
103078335  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
103084259  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
103070606  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103086990  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
103086643  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
103090568  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103086989  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X1 [KO:K11351]
103073569  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
103084921  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
103072944  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103084967  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
103090037  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103087074  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103085530  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103068684  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
103070556  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103080397  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
103090475  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103078950  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
103086971  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
103087853  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103087521  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
103076796  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
3802092  CYTB; cytochrome b [KO:K00412]
103081975  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
103089566  cytochrome b-c1 complex subunit 1, mitochondrial-like [KO:K00414]
103072340  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
103080944  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
103090168  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
103081405  cytochrome b-c1 complex subunit 7-like [KO:K00417]
103079404  cytochrome b-c1 complex subunit 7-like [KO:K00417]
103088883  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103071217  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103085535  cytochrome b-c1 complex subunit 9-like [KO:K00419]
103083511  cytochrome b-c1 complex subunit 10-like [KO:K00420]
103082886  cytochrome b-c1 complex subunit 10-like [KO:K00420]
103068399  cytochrome b-c1 complex subunit 10-like [KO:K00420]
3802098  COX3; cytochrome c oxidase subunit III [KO:K02262]
3802094  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3802095  COX2; cytochrome c oxidase subunit II [KO:K02261]
103086428  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
103081720  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
103074089  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
103085487  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
103073019  cytochrome c oxidase subunit 6A2, mitochondrial-like [KO:K02266]
103080257  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
103072827  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103073864  cytochrome c oxidase subunit 6C-like [KO:K02268]
103072782  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
103076103  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
103081207  cytochrome c oxidase subunit 7A1, mitochondrial-like [KO:K02270]
103082153  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
103079623  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
103071977  cytochrome c oxidase subunit 7B, mitochondrial-like isoform X1 [KO:K02271]
103087636  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
103073988  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
103078143  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103087229  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
103070384  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
103082578  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
3802097  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103070520  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103091253  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
103074026  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
103089849  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
103079342  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
103083487  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
103077125  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
103088939  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
3802096  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103069014  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
103073695  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
103087514  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
103087912  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103068650  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103083138  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103091053  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103075399  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103085453  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
103072982  SOD1; superoxide dismutase [Cu-Zn] isoform X1 [KO:K04565] [EC:1.15.1.1]
103076772  CAT; catalase [KO:K03781] [EC:1.11.1.6]
103068768  SLC26A1; LOW QUALITY PROTEIN: sulfate anion transporter 1 [KO:K14700]
103075397  SLC26A2; sulfate transporter [KO:K14701]
103081802  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
103078915  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
103071784  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
103086718  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
103071513  cytochrome P450 1A1-like [KO:K07408] [EC:1.14.14.1]
103083349  cytochrome P450 1B1-like [KO:K07410] [EC:1.14.14.1]
103074317  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
103082628  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
103086935  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
103072261  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
103076421  AKR1A1; alcohol dehydrogenase [NADP(+)] isoform X1 [KO:K00002] [EC:1.1.1.2]
103069218  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103077151  NQO1; LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
103084663  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103071592  AHR; LOW QUALITY PROTEIN: aryl hydrocarbon receptor [KO:K09093]
103083002  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
103083150  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
103090543  cytochrome b-245 light chain-like [KO:K08009]
103087970  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
103072544  NCF1; neutrophil cytosol factor 1 [KO:K08011]
103068860  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103090018  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103091203  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103091499  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103084433  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
103072956  uncharacterized protein LOC103072956 [KO:K04379]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103081765  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103084467  FOXO3; forkhead box protein O3 [KO:K09408]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103086578  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
103074298  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103073166  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
103077635  PTPRJ; receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
103069518  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103088783  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103076172  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
103079814  ABL2; Abelson tyrosine-protein kinase 2 [KO:K08887] [EC:2.7.10.2]
103084165  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
103090978  PRKD1; serine/threonine-protein kinase D1-like [KO:K06070] [EC:2.7.11.13]
103089542  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103069742  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103084538  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103082490  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103073387  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
103075373  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103083057  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
103071090  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
103077914  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
lve00190  Oxidative phosphorylation
lve00980  Metabolism of xenobiotics by cytochrome P450
lve04010  MAPK signaling pathway
lve04064  NF-kappa B signaling pathway
lve04066  HIF-1 signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04370  VEGF signaling pathway
lve05207  Chemical carcinogenesis - receptor activation
lve05211  Renal cell carcinoma
lve05215  Prostate cancer
lve05219  Bladder cancer
lve05221  Acute myeloid leukemia
lve05222  Small cell lung cancer
lve05223  Non-small cell lung cancer
lve05224  Breast cancer
lve05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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