KEGG   PATHWAY: mcal05146
Entry
mcal05146                   Pathway                                
Name
Amoebiasis - Mus caroli (Ryukyu mouse)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
mcal05146  Amoebiasis
mcal05146

Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110290100  Il1b; interleukin-1 beta [KO:K04519]
110293878  Il1r1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
110302131  Il1r2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285703  Rela; transcription factor p65 [KO:K04735]
110298090  Muc2; mucin-2 [KO:K10955]
110296014  Col1a2; collagen alpha-2(I) chain [KO:K06236]
110304196  Col1a1; collagen alpha-1(I) chain [KO:K06236]
110286404  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
110299671  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
110299672  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
110289599  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
110295504  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
110286219  Col4a5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
110283623  Fn1; fibronectin isoform X1 [KO:K05717]
110302840  Lama2; laminin subunit alpha-2 isoform X3 [KO:K05637]
110312520  Lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
110285111  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
110302955  Lama4; laminin subunit alpha-4 [KO:K06241]
110306938  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
110301253  Lamb2; laminin subunit beta-2 [KO:K06243]
110305044  Lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
110311961  Lamc1; laminin subunit gamma-1 [KO:K05635]
110300039  Lamc2; laminin subunit gamma-2 [KO:K06246]
110312505  Lamc3; laminin subunit gamma-3 isoform X2 [KO:K06247]
110299851  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110285306  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
110303103  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110285572  Gna14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
110303522  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
110285320  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110290514  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110286326  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
110308867  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110308282  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110308334  neuroendocrine secretory protein 55 [KO:K04632]
110284817  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110312675  Rab5a; ras-related protein Rab-5A [KO:K07887]
110291569  ras-related protein Rab-5B [KO:K07888]
110303170  Rab5b; ras-related protein Rab-5B [KO:K07888]
110305560  Rab5c; ras-related protein Rab-5C [KO:K07889]
110305273  ras-related protein Rab-7a [KO:K07897]
110295700  Rab7a; ras-related protein Rab-7a [KO:K07897]
110303526  Rab7b; ras-related protein Rab-7b isoform X1 [KO:K07898]
110291353  Tlr2; toll-like receptor 2 [KO:K10159]
110293229  Tlr4; toll-like receptor 4 [KO:K10160]
110284977  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110295330  Il6; interleukin-6 [KO:K05405]
110294442  C-X-C motif chemokine 3 [KO:K05505]
110294443  growth-regulated alpha protein [KO:K05505]
110295209  C-X-C motif chemokine 2 [KO:K05505]
110305989  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110284110  Tnf; tumor necrosis factor [KO:K03156]
110291699  Il12a; interleukin-12 subunit alpha [KO:K05406]
110304465  Il12b; interleukin-12 subunit beta [KO:K05425]
110290701  Cd1d; antigen-presenting glycoprotein CD1d [KO:K06448]
110290702  antigen-presenting glycoprotein CD1d1-like [KO:K06448]
110303854  Ifng; interferon gamma [KO:K04687]
110285908  Col3a1; collagen alpha-1(III) chain [KO:K19720]
110310271  Ptk2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
110309685  Vcl; vinculin isoform X2 [KO:K05700]
110298906  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110306555  Actn1; alpha-actinin-1 [KO:K05699]
110306718  Arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
110303027  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
110304621  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110311769  integrin beta-2-like protein [KO:K06464]
110303281  Itgb2; integrin beta-2 [KO:K06464]
110298307  Itgam; integrin alpha-M isoform X2 [KO:K06461]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110293023  Prdx1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
110288725  serpin B9-like [KO:K13963]
110307947  serpin B6 isoform X4 [KO:K13963]
110308240  serpin B9-like [KO:K13963]
110302199  Serpinb10; serpin B10 isoform X1 [KO:K13963]
110299340  serpin B4-like [KO:K13963]
110308463  LOW QUALITY PROTEIN: serpin B6-like [KO:K13963]
110308252  serpin B6-like isoform X1 [KO:K13963]
110303371  Serpinb13; serpin B13 isoform X1 [KO:K13963]
110288876  serpin B9-like [KO:K13963]
110300736  serpin B4-like isoform X1 [KO:K13963]
110301966  serpin B4-like isoform X1 [KO:K13963]
110308262  serpin B9-like [KO:K13963]
110288367  serpin B9-like [KO:K13963]
110308182  serpin B6-like [KO:K13963]
110288368  serpin B9-like [KO:K13963]
110309192  cathepsin G [KO:K01319] [EC:3.4.21.20]
110304323  Il10; interleukin-10 [KO:K05443]
110298438  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110292955  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
110306834  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110292511  C8a; complement component C8 alpha chain isoform X1 [KO:K03997]
110292205  C8b; complement component C8 beta chain isoform X2 [KO:K03998]
110284736  C8g; complement component C8 gamma chain [KO:K03999]
110310523  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
mcal00330  Arginine and proline metabolism
mcal00590  Arachidonic acid metabolism
mcal04144  Endocytosis
mcal04210  Apoptosis
mcal04510  Focal adhesion
mcal04610  Complement and coagulation cascades
mcal04612  Antigen processing and presentation
mcal04620  Toll-like receptor signaling pathway
mcal04672  Intestinal immune network for IgA production
mcal04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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