KEGG   PATHWAY: mcal04510
Entry
mcal04510                   Pathway                                
Name
Focal adhesion - Mus caroli (Ryukyu mouse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcal04510  Focal adhesion
mcal04510

Other DBs
GO: 0005925
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110283623  Fn1; fibronectin isoform X1 [KO:K05717]
110284402  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110284478  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110284518  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110285111  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
110285202  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110285279  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
110285481  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110285491  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
110285509  Itga6; integrin alpha-6 isoform X2 [KO:K06485]
110285510  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110285541  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110286219  Col4a5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
110286404  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
110286479  Pak3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
110286671  Xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
110286681  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110287326  Vegfd; vascular endothelial growth factor D [KO:K05449]
110287345  Flna; filamin-A isoform X1 [KO:K04437]
110288037  [KO:K06269] [EC:3.1.3.16]
110288173  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110289008  Itga4; integrin alpha-4 [KO:K06483]
110289369  Itga8; integrin alpha-8 [KO:K06584]
110289454  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110289599  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
110289726  Shc4; SHC-transforming protein 4 [KO:K17449]
110289784  Itgb6; integrin beta-6 [KO:K06589]
110290127  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110290661  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110290697  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
110290706  Thbs3; thrombospondin-3 [KO:K04659]
110290710  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110291192  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110291521  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110292364  Tln1; talin-1 isoform X4 [KO:K06271]
110292411  [KO:K04513]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110292624  [KO:K02649]
110292855  Tnc; tenascin isoform X1 [KO:K06252]
110292982  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
110293177  Tnr; tenascin-R isoform X1 [KO:K06252]
110293509  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
110293615  Col6a3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
110293855  Pxn; paxillin isoform X1 [KO:K05760]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110294013  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110294038  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110294216  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110294526  Spp1; osteopontin [KO:K06250]
110294607  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110294798  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
110294931  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110295174  Myl10; myosin regulatory light chain 10 [KO:K12756]
110295282  Ibsp; bone sialoprotein 2 isoform X1 [KO:K06253]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110295381  Actb; actin, cytoplasmic 1 [KO:K05692]
110295447  Reln; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
110295504  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
110295806  Vwf; von Willebrand factor [KO:K03900]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110295947  Met; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
110296014  Col1a2; collagen alpha-2(I) chain [KO:K06236]
110296327  Emp1; epithelial membrane protein 1 [KO:K26255]
110296334  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110296563  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110296653  Cav2; caveolin-2 [KO:K12958]
110296656  Cav1; caveolin-1 [KO:K06278]
110296907  Cav3; caveolin-3 [KO:K12959]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110297068  Zyx; zyxin isoform X1 [KO:K06273]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110297432  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
110297547  Parva; alpha-parvin [KO:K06275]
110297590  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110297818  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110297825  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110297840  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
110297879  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110298189  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
110298300  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110298899  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
110298906  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110299313  Tnn; tenascin-N [KO:K06252]
110299376  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
110299671  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
110299672  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110299902  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
110299930  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110300039  Lamc2; laminin subunit gamma-2 [KO:K06246]
110300171  Vegfc; vascular endothelial growth factor C [KO:K05449]
110300418  Comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
110300419  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110301052  Ctnnb1; catenin beta-1 [KO:K02105]
110301253  Lamb2; laminin subunit beta-2 [KO:K06243]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110301527  Itga9; integrin alpha-9 [KO:K06585]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110301610  Itga11; integrin alpha-11 [KO:K06587]
110301861  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
110301905  Col6a6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
110301934  [KO:K06238]
110301979  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
110302303  [KO:K16060]
110302359  Tln2; talin-2 [KO:K06271]
110302433  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110302840  Lama2; laminin subunit alpha-2 isoform X3 [KO:K05637]
110302898  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
110302933  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X4 [KO:K06270]
110302943  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110302948  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
110302955  Lama4; laminin subunit alpha-4 [KO:K06241]
110302997  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
110303320  Rap1b; ras-related protein Rap-1b [KO:K07836]
110303444  Shc2; SHC-transforming protein 2 [KO:K17447]
110303716  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
110304009  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304196  Col1a1; collagen alpha-1(I) chain [KO:K06236]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110304271  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
110304283  Actg1; actin, cytoplasmic 2 [KO:K05692]
110304308  Itga3; integrin alpha-3 [KO:K06482]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110304471  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110304730  Chad; chondroadherin [KO:K06248]
110304761  Itga2b; integrin alpha-IIb [KO:K06476]
110304771  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110304772  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110305044  Lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
110305072  Itgb3; integrin beta-3 [KO:K06493]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110305233  Crk; adapter molecule crk isoform X1 [KO:K04438]
110305591  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110305821  Vtn; vitronectin [KO:K06251]
110306555  Actn1; alpha-actinin-1 [KO:K05699]
110306686  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
110306770  Arhgap5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
110306938  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307029  Pgf; placenta growth factor [KO:K16859]
110307232  Itgb8; integrin beta-8 [KO:K06591]
110307562  Itga1; integrin alpha-1 [KO:K06480]
110307773  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
110307848  Thbs4; thrombospondin-4 [KO:K04659]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110308074  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
110308134  Shc3; SHC-transforming protein 3 [KO:K17448]
110308670  [KO:K00907] [EC:2.7.11.18]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308932  Flnb; filamin-B isoform X1 [KO:K27392]
110309132  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
110309685  Vcl; vinculin isoform X2 [KO:K05700]
110310031  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110310133  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110310271  Ptk2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
110310274  Parvb; beta-parvin isoform X1 [KO:K06275]
110310431  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
110310456  Itga5; integrin alpha-5 [KO:K06484]
110310547  Itgb7; integrin beta-7 [KO:K06590]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110310654  Parvg; gamma-parvin isoform X1 [KO:K06275]
110310932  Thbs1; thrombospondin-1 isoform X2 [KO:K16857]
110311058  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110311174  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110311365  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110311434  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110311493  Itgb5; integrin beta-5 [KO:K06588]
110311596  Crkl; crk-like protein [KO:K04438]
110311846  Emp2; epithelial membrane protein 2 [KO:K26256]
110311961  Lamc1; laminin subunit gamma-1 [KO:K05635]
110312338  [KO:K12757]
110312339  Myl12b; myosin regulatory light chain 12B [KO:K12757]
110312346  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110312395  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110312505  Lamc3; laminin subunit gamma-3 isoform X2 [KO:K06247]
110312516  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
110312520  Lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
110312587  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
110312609  Thbs2; thrombospondin-2 [KO:K04659]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mcal04010  MAPK signaling pathway
mcal04060  Cytokine-cytokine receptor interaction
mcal04070  Phosphatidylinositol signaling system
mcal04110  Cell cycle
mcal04151  PI3K-Akt signaling pathway
mcal04310  Wnt signaling pathway
mcal04512  ECM-receptor interaction
mcal04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

DBGET integrated database retrieval system