Entry Name Platelet activation - Sciurus carolinensis (gray squirrel)
Description Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Sciurus carolinensis (gray squirrel) [GN:
ncar ]
Gene 124979863 LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639 ]
124973058 LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639 ]
124982345 protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270 ]
124990787 calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056 ]
124970932 inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
124983533 inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
124964255 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
124962318 amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
124992673 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
124988012 guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
124991078 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
124975134 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
124991973 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
124980224 phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290 ]
124981277 phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
124965656 LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein-like [KO:K06274 ]
124966409 LOW QUALITY PROTEIN: rho GTPase-activating protein 35-like [KO:K05732 ]
124993167 low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06472 ]
124994061 high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
124963509 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
124986648 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
124968815 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Li Z, Delaney MK, O'Brien KA, Du X
Title Signaling during platelet adhesion and activation.
Journal Reference Authors Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title Blood platelet biochemistry.
Journal Reference Authors Jurk K, Kehrel BE
Title Platelets: physiology and biochemistry.
Journal Reference Authors Offermanns S
Title Activation of platelet function through G protein-coupled receptors.
Journal Reference Authors Varga-Szabo D, Pleines I, Nieswandt B
Title Cell adhesion mechanisms in platelets.
Journal Reference Authors Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal Reference Authors Bergmeier W, Stefanini L
Title Novel molecules in calcium signaling in platelets.
Journal Reference Authors Cifuni SM, Wagner DD, Bergmeier W
Title CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal Reference Authors Heemskerk JW, Mattheij NJ, Cosemans JM
Title Platelet-based coagulation: different populations, different functions.
Journal Reference Authors Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title Platelet receptors and signaling in the dynamics of thrombus formation.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Angiolillo DJ, Ferreiro JL
Title Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal Reference Authors Joo SJ
Title Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal Reference Authors Harper MT, Poole AW
Title Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal Reference Authors Fitch-Tewfik JL, Flaumenhaft R
Title Platelet granule exocytosis: a comparison with chromaffin cells.
Journal Reference Authors Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal Related ncar04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
