KEGG   PATHWAY: npr04148
Entry
npr04148                    Pathway                                
Name
Efferocytosis - Nanorana parkeri (Xizang Plateau frog)
Class
Cellular Processes; Transport and catabolism
Pathway map
npr04148  Efferocytosis
npr04148

Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108794589  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108794597  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108793513  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
108792468  caspase-7-like [KO:K04397] [EC:3.4.22.60]
108790873  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
108787306  PANX1; pannexin-1 [KO:K03443]
108796044  P2Y purinoceptor 2-like [KO:K04269]
108784435  P2RY2; P2Y purinoceptor 2 [KO:K04269]
108784439  P2RY6; P2Y purinoceptor 6 [KO:K04272]
108794779  P2RY12; P2Y purinoceptor 12 [KO:K04298]
108804675  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
108796856  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108791467  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
108799210  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
108794435  ABCA1; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 1 [KO:K05641]
108786993  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
108789869  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
108789826  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
108796952  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
108795666  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
108784253  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
108789084  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108792372  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108791966  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
108789811  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
108799511  EPO; erythropoietin [KO:K05437]
108799818  EPOR; erythropoietin receptor [KO:K05079]
108798500  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108794889  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108798393  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
108785475  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
108795632  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108799956  MFGE8; lactadherin isoform X1 [KO:K17253]
108792207  GAS6; growth arrest-specific protein 6 [KO:K05464]
108801088  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
108792726  CD36; platelet glycoprotein 4 [KO:K06259]
108796832  THBS1; thrombospondin-1 [KO:K16857]
108784101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108798706  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108788581  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
108790814  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
108790202  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108800768  transforming growth factor beta-1-like [KO:K13375]
108784529  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
108802336  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
108796871  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
108804479  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108785806  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108785601  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108798063  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
108804838  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108804839  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108787378  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108788240  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
108793180  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108800085  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
108794525  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108791934  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108794413  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108791570  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108792108  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108789456  ANO6; anoctamin-6 [KO:K19500]
108793133  anoctamin-3-like [KO:K19498]
108787172  ANO4; anoctamin-4 isoform X1 [KO:K19499]
108792275  ANO5; LOW QUALITY PROTEIN: anoctamin-5 [KO:K19480]
108802175  ANO7L1; LOW QUALITY PROTEIN: anoctamin-7 [KO:K19501]
108790993  ANO9; anoctamin-9 [KO:K19503]
108790345  BSG; basigin isoform X1 [KO:K06535]
108795602  XKR8; XK-related protein 8 [KO:K26813]
108791757  XKR9; XK-related protein 9 [KO:K26814]
108786984  XKR7; XK-related protein 7 [KO:K26811]
108789968  XKR4; XK-related protein 4 [KO:K26811]
108798183  XK-related protein 6 [KO:K26811]
108795175  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
108793825  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
108791701  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
108793200  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
108795768  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
108788998  TMEM30A; cell cycle control protein 50A isoform X1 [KO:K26935]
108797304  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
108794469  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108797421  ITGB3; integrin beta-3 [KO:K06493]
108791265  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
108795852  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
108789922  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
108787998  hepatitis A virus cellular receptor 1 homolog [KO:K20413]
108791869  STAB1; stabilin-1 [KO:K19020]
108789607  STAB2; stabilin-2 [KO:K19013]
108792768  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108796559  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
108801710  CRK; adapter molecule crk isoform X1 [KO:K04438]
108802369  CRKL; crk-like protein isoform X1 [KO:K04438]
108792222  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108790880  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
108794473  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108784770  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
108795410  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
108801525  CALR; calreticulin [KO:K08057]
108783796  calreticulin-like [KO:K08057]
108803991  C1QA; complement C1q subcomponent subunit A [KO:K03986]
108804086  C1QB; complement C1q subcomponent subunit B [KO:K03987]
108803990  complement C1q subcomponent subunit C-like [KO:K03988]
108797935  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
108784108  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
108794075  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
108801701  SCARF1; scavenger receptor class F member 1 [KO:K24318]
108797616  GULP1; PTB domain-containing engulfment adapter protein 1 [KO:K23285]
108789831  RAB17; ras-related protein Rab-17 [KO:K07909]
108797632  RAB5A; ras-related protein Rab-5A [KO:K07887]
108790530  RAB5B; ras-related protein Rab-5B [KO:K07888]
108784960  ras-related protein Rab-5B-like [KO:K07888]
108788937  RAB5C; ras-related protein Rab-5C [KO:K07889]
108792629  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
108794834  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
108795003  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
108799763  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108791497  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108794344  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
108787466  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
108793654  RAB14; ras-related protein Rab-14 [KO:K07881]
108789292  VPS39; vam6/Vps39-like protein [KO:K20183]
108788881  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
108790460  ras-related protein Rab-7a-like [KO:K07897]
108784979  RAB7A; ras-related protein Rab-7a [KO:K07897]
108799479  lysosomal amino acid transporter 1 homolog [KO:K23678]
108803891  lysosomal amino acid transporter 1 homolog [KO:K23678]
108794160  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
108796227  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
108793530  antizyme inhibitor 2 isoform X1 [KO:K01581] [EC:4.1.1.17]
108789525  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
108804259  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
108796192  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
108796200  LOW QUALITY PROTEIN: cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
108788867  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
108788868  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
108788869  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
108792106  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
108795865  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
108792107  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
108793465  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
108784293  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
108801625  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
108789127  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
108793183  IL10; interleukin-10 [KO:K05443]
108788862  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
108788872  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
108801424  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
108790364  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
108802930  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
108790557  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
108794122  serine/threonine-protein kinase Sgk1-A isoform X1 [KO:K13302] [EC:2.7.11.1]
108797636  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
108784384  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
108790634  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
108798021  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
npr00010  Glycolysis / Gluconeogenesis
npr04140  Autophagy - animal
npr04145  Phagosome
KO pathway
ko04148   
LinkDB

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