KEGG   PATHWAY: oke04622
Entry
oke04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Oncorhynchus keta (chum salmon)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
oke04622  RIG-I-like receptor signaling pathway
oke04622

Organism
Oncorhynchus keta (chum salmon) [GN:oke]
Gene
118383869  rigi; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
118386002  interferon-induced helicase C domain-containing protein 1-like isoform X1 [KO:K12647] [EC:5.6.2.6]
118400607  NFX1-type zinc finger-containing protein 1-like [KO:K27391]
118389368  NFX1-type zinc finger-containing protein 1-like [KO:K27391]
118377545  fibrous sheath CABYR-binding protein [KO:K12648]
118372177  ATP-dependent RNA helicase DHX58-like [KO:K12649] [EC:5.6.2.6]
118365264  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
118362713  TNF receptor-associated factor 3 [KO:K03174]
118368117  TNF receptor-associated factor 3-like [KO:K03174]
118385999  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
118367113  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
127921382  azi2; LOW QUALITY PROTEIN: 5-azacytidine-induced protein 2 [KO:K12651]
118367051  tbkbp1; TANK-binding kinase 1-binding protein 1 [KO:K12652]
118365187  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
118357648  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
118384422  TANK-binding kinase 1-binding protein 1-like isoform X1 [KO:K12652]
118379875  NF-kappa-B essential modulator-like [KO:K07210]
118376297  LOW QUALITY PROTEIN: NF-kappa-B essential modulator-like [KO:K07210]
127927215  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
127921842  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
118376589  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118363689  irf3; interferon regulatory factor 3 [KO:K05411]
118370930  interferon regulatory factor 7-like [KO:K09447]
118395745  irf7; interferon regulatory factor 7 [KO:K09447]
118384397  LOW QUALITY PROTEIN: interferon a3 [KO:K05414]
118370402  interferon kappa-like [KO:K05414]
127929989  uncharacterized protein LOC127929989 isoform X1 [KO:K05414]
118384396  interferon a3-like [KO:K05414]
127929990  interferon a3-like isoform X1 [KO:K05414]
118384401  interferon a3-like isoform X1 [KO:K05414]
127929991  interferon a3-like [KO:K05414]
118384399  interferon beta-like [KO:K05414]
127929992  interferon a3-like [KO:K05414]
118364724  interferon beta-like [KO:K05414]
118364723  interferon alpha-3-like [KO:K05414]
127914469  interferon beta-like [KO:K05414]
127914470  interferon beta-like [KO:K05414]
127914471  interferon beta-like [KO:K05414]
127914472  interferon beta-like [KO:K05414]
118380665  interferon beta-like [KO:K05414]
127930382  interferon beta-like [KO:K05414]
127930383  interferon beta-like [KO:K05414]
118384763  interferon a3-like [KO:K05414]
127930384  interferon a3-like [KO:K05414]
118365427  ifnphi4; interferon phi 4 isoform X1 [KO:K05414]
118365758  interferon alpha-6-like [KO:K05414]
118380663  interferon a3-like isoform X1 [KO:K05414]
118380664  interferon a3-like [KO:K05414]
118384398  interferon beta-like [KO:K05414]
118384400  interferon a3 isoform X1 [KO:K05414]
118384758  interferon a3-like [KO:K05414]
118384762  interferon beta-like [KO:K05414]
118384764  interferon a3-like isoform X1 [KO:K05414]
118384765  interferon a3-like [KO:K05414]
118384769  interferon alpha-G-like [KO:K05414]
118393895  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
118359756  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
118393704  fadd; protein FADD [KO:K02373]
118402001  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
118394771  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
118401858  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
118395010  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118386445  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
118367039  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118363556  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118366609  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118357674  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
118371603  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118386666  NF-kappa-B inhibitor alpha-like [KO:K04734]
118362691  NF-kappa-B inhibitor alpha-like isoform X1 [KO:K04734]
118372419  NF-kappa-B inhibitor alpha-like [KO:K04734]
118368141  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
118363406  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
118376596  nuclear factor NF-kappa-B p105 subunit-like isoform X2 [KO:K02580]
118368674  transcription factor p65-like isoform X1 [KO:K04735]
118391902  putative transcription factor p65 homolog isoform X1 [KO:K04735]
118385316  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
118385484  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118393434  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
118387519  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118379005  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
118386791  mitogen-activated protein kinase kinase kinase 7-like isoform X7 [KO:K04427] [EC:2.7.11.25]
118362329  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
118368467  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
118381203  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118385561  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
118387265  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118369466  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118402372  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118373295  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118387819  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118385734  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118375883  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118367713  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118357754  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118360165  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118360174  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118401077  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118360604  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
118361231  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118373032  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118395817  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
118365973  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
118389610  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
118366309  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118399916  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118392440  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
118392441  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118396910  interleukin-8-like [KO:K10030]
118365565  interleukin-8-like [KO:K10030]
118384796  permeability factor 2-like [KO:K10030]
118384797  permeability factor 2-like [KO:K10030]
118392643  permeability factor 2-like [KO:K10030]
118367411  tumor necrosis factor [KO:K03156]
118378789  tumor necrosis factor-like [KO:K03156]
118380315  tumor necrosis factor [KO:K03156]
118394530  interleukin-12 subunit alpha-like [KO:K05406]
118395174  uncharacterized protein LOC118395174 [KO:K05406]
118396950  uncharacterized protein LOC118396950 [KO:K05406]
118380892  interleukin-12 subunit beta-like [KO:K05425]
118376493  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
118389797  interleukin-12 subunit beta-like isoform X1 [KO:K05425]
118376823  interleukin-12 subunit beta-like [KO:K05425]
118390834  interleukin-12 subunit beta-like [KO:K05425]
118373092  permeability factor 2-like [KO:K12671]
118373734  LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase-like [KO:K12968] [EC:3.5.4.37]
118373735  adar; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
118359809  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
118368930  zgc:92594; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
118360923  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
118397270  ftr86; finTRIM family, member 86 [KO:K10652] [EC:2.3.2.27]
118364970  E3 ubiquitin/ISG15 ligase TRIM25 isoform X2 [KO:K10652] [EC:2.3.2.27]
118389202  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]
118392168  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]
118382671  E3 ubiquitin-protein ligase TRIM47-like isoform X1 [KO:K10652] [EC:2.3.2.27]
118368914  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
118375573  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
118388378  cyldb; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
118373428  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
118382141  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
118400112  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
118364467  autophagy protein 5-like [KO:K08339]
118367522  autophagy protein 5-like [KO:K08339]
118374050  ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
127915256  ubiquitin-like protein ATG12 [KO:K08336]
118386221  NLR family member X1-like [KO:K12653]
118372926  stimulator of interferon genes protein-like [KO:K12654]
118381455  stimulator of interferon genes protein-like [KO:K12654]
118359558  otud5a; OTU domain-containing protein 5-A isoform X1 [KO:K12655] [EC:3.4.19.12]
118360963  sike1; suppressor of IKBKE 1 [KO:K12656]
118370595  putative ATP-dependent RNA helicase an3 isoform X1 [KO:K11594] [EC:5.6.2.7]
118363203  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
118372373  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
118366722  ATP-dependent RNA helicase DDX3Y-like isoform X4 [KO:K11594] [EC:5.6.2.7]
127928012  pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1 [KO:K09578] [EC:5.2.1.8]
127919400  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like [KO:K09578] [EC:5.2.1.8]
127922158  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like [KO:K09578] [EC:5.2.1.8]
118382238  LOW QUALITY PROTEIN: triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
127923862  LOW QUALITY PROTEIN: triokinase/FMN cyclase-like [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
oke04010  MAPK signaling pathway
oke04120  Ubiquitin mediated proteolysis
oke04210  Apoptosis
KO pathway
ko04622   
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