KEGG   PATHWAY: otw04068
Entry
otw04068                    Pathway                                
Name
FoxO signaling pathway - Oncorhynchus tshawytscha (Chinook salmon)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
otw04068  FoxO signaling pathway
otw04068

Other DBs
GO: 0009267
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112231247  transforming growth factor beta-1 proprotein [KO:K13375]
112228884  transforming growth factor beta-1 proprotein [KO:K13375]
112240152  transforming growth factor beta-1 proprotein-like [KO:K13375]
112255920  transforming growth factor beta-2 proprotein-like [KO:K13376]
112223175  transforming growth factor beta-2 proprotein [KO:K13376]
112234066  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
112221169  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
112217963  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112256698  transforming growth factor beta-3 proprotein [KO:K13377]
112238812  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112233166  transforming growth factor beta-3 proprotein-like [KO:K13377]
112260530  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112227836  tgfbr1b; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
112226882  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112215283  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112264984  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112225563  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
112239812  LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112239013  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112241489  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112229968  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121843252  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
112228561  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
112229740  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112257537  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112248311  mothers against decapentaplegic homolog 4 [KO:K04501]
112222845  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112219493  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
112263427  mothers against decapentaplegic homolog 4 [KO:K04501]
112264720  mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
112235777  mothers against decapentaplegic homolog 3 [KO:K23605]
112238080  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
112250849  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112260836  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112226590  LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112251091  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112230882  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112220217  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112260362  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112260862  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
112248390  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
112226519  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
112219380  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
112253920  5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
112233576  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
112254606  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
112260549  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112232700  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
112240217  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
112226860  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112217541  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112251290  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
112258406  serine/threonine-protein kinase NLK2 isoform X1 [KO:K04468] [EC:2.7.11.24]
112267223  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112265656  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112257530  S-phase kinase-associated protein 2 [KO:K03875]
112262208  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112220930  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
112226125  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112224788  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112258529  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
112225784  crebbpb; LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
112238381  crebbpa; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
112258813  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
112252524  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
112252789  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
112240744  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
112260046  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
112214760  solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
112252764  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112220751  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112252352  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112224208  mitogen-activated protein kinase 8-like isoform X3 [KO:K04440] [EC:2.7.11.24]
112231415  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
112219617  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112257338  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112223506  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112254134  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
112214206  insulin-like growth factor I isoform X1 [KO:K05459]
112217005  insulin-like growth factor I isoform X1 [KO:K05459]
112218557  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112252377  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112224871  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112255913  insulin-like [KO:K04526]
112259393  insulin [KO:K04526]
112234673  insulin-like [KO:K04526]
112251212  insulin receptor [KO:K04527] [EC:2.7.10.1]
112251449  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
112226585  insulin receptor [KO:K04527] [EC:2.7.10.1]
112260900  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
112229124  insulin receptor substrate 1-B-like [KO:K16172]
112257780  insulin receptor substrate 1-B-like [KO:K16172]
112216688  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
112259956  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
112233838  LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172]
112230587  insulin receptor substrate 2-B-like [KO:K07187]
112214510  insulin receptor substrate 2-B [KO:K07187]
112266609  LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
112225416  insulin receptor substrate 2 [KO:K07187]
112220193  insulin receptor substrate 2-like [KO:K07187]
112241326  insulin receptor substrate 2 [KO:K07187]
112236594  LOW QUALITY PROTEIN: insulin receptor substrate 2-B [KO:K07187]
112267269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112216060  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112260202  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112227144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112251044  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112265788  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112266167  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
112260699  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112250738  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112260309  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112244626  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
112252131  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112226747  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112248937  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112230790  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
112234933  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112250872  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112220315  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112224117  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
112223683  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112223895  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112224128  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112223622  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112263933  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112253032  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112254533  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112224277  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112223442  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112250387  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112256640  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112225150  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112261841  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112230362  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265711  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112224566  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265172  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112217662  RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
112231417  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112267273  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112237373  sgk1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
112264320  serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
112229574  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121846459  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
112215824  serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
112254332  serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
112222127  serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
112233608  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
112234075  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
112239895  foxo1a; forkhead box protein O1-A [KO:K07201]
112218371  forkhead box protein O1-A [KO:K07201]
112228186  forkhead box protein O1-A [KO:K07201]
112217801  foxo3b; forkhead box protein O3B [KO:K09408]
112261501  forkhead box protein O3 [KO:K09408]
112250331  forkhead box protein O3-like [KO:K09408]
112256920  forkhead box protein O3 [KO:K09408]
112256219  forkhead box protein O4 [KO:K12358]
112220917  forkhead box protein O4 [KO:K12358]
112246612  forkhead box protein O3-like [KO:K17847]
112246120  forkhead box protein O6-like [KO:K17847]
112232976  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
112217708  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
112261499  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
112244609  homer protein homolog 3 isoform X1 [KO:K15010]
112250730  homer3b; homer protein homolog 3b isoform X1 [KO:K15010]
112260318  homer protein homolog 3 isoform X1 [KO:K15010]
112220280  LOW QUALITY PROTEIN: homer protein homolog 1 [KO:K15010]
112242394  homer protein homolog 2 [KO:K15010]
112252119  homer protein homolog 3 isoform X1 [KO:K15010]
112248952  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
112230821  homer protein homolog 1 [KO:K15010]
112216339  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
112226146  casein kinase I [KO:K08960] [EC:2.7.11.1]
112258765  casein kinase I [KO:K08960] [EC:2.7.11.1]
112258792  casein kinase I [KO:K08960] [EC:2.7.11.1]
112224408  casein kinase I [KO:K08960] [EC:2.7.11.1]
112235861  il6; interleukin-6 [KO:K05405]
112264462  interleukin-6-like isoform X1 [KO:K05405]
112236527  interleukin-10 [KO:K05443]
121846822  il10; interleukin-10 [KO:K05443]
112258660  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112225989  signal transducer and activator of transcription 3-like isoform X1 [KO:K04692]
112256330  egf; pro-epidermal growth factor [KO:K04357]
112232691  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
112226767  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112260663  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112227760  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
112234604  growth factor receptor-bound protein 2 [KO:K04364]
112230281  growth factor receptor-bound protein 2 [KO:K04364]
112264096  growth factor receptor-bound protein 2 [KO:K04364]
112258867  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112265983  LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
112230419  son of sevenless homolog 1 isoform X1 [KO:K03099]
112262240  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
112255836  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
112252501  GTPase HRas [KO:K02833]
112218668  GTPase HRas [KO:K02833]
112252543  GTPase KRas isoform X1 [KO:K07827]
112226270  zgc:55558 [KO:K07827]
112218714  kras; GTPase KRas isoform X1 [KO:K07827]
121843711  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
112215764  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
112222214  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
112248687  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112265332  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
112262497  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112250875  map2k2a; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112231367  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112237794  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
112262493  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251950  mapk3; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251959  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112237408  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112242516  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112252549  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112214239  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112214240  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
112221631  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221641  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112215918  mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
112254157  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221833  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
112216970  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112216971  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112235071  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112218743  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112216384  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112254710  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112216259  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112252028  protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
112252080  protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
112253136  forkhead box protein G1 [KO:K09385]
112267175  forkhead box protein G1-like [KO:K09385]
112244930  foxg1a; forkhead box protein G1 [KO:K09385]
112265972  forkhead box protein G1-like [KO:K09385]
112256829  forkhead box protein G1-like [KO:K09385]
112255550  forkhead box protein G1 [KO:K09385]
112230962  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112220405  G2/mitotic-specific cyclin-B1 [KO:K05868]
112264049  G2/mitotic-specific cyclin-B1-like [KO:K05868]
112249181  G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
112263712  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
112259703  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
112231150  G2/mitotic-specific cyclin-B3 [KO:K21771]
112218887  G1/S-specific cyclin-D1 [KO:K04503]
112252678  G1/S-specific cyclin-D1 [KO:K04503]
112263573  G1/S-specific cyclin-D1 [KO:K04503]
112249039  G1/S-specific cyclin-D1 [KO:K04503]
112214224  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112252585  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112216983  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112218786  ccnd2a; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112259254  ccndx; LOW QUALITY PROTEIN: cyclin Dx [KO:K10151]
112263138  cyclin-G2 isoform X1 [KO:K10146]
112232838  cyclin-G2 [KO:K10146]
112257322  cyclin-G2 [KO:K10146]
112220028  cyclin-G2 isoform X2 [KO:K10146]
112238791  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
112230133  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
112217839  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112254565  cyclin-dependent kinase inhibitor 1C [KO:K06625]
112214357  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112216848  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112214453  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112216753  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112218171  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112240696  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112218825  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112252634  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112264064  retinoblastoma-like protein 2 [KO:K16332]
112249362  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112241904  plk1; serine/threonine-protein kinase PLK1 isoform X1 [KO:K06631] [EC:2.7.11.21]
112220000  serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
112248580  serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
112262795  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
112260461  serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
112226947  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
112256743  serine/threonine-protein kinase PLK4-like isoform X1 [KO:K08863] [EC:2.7.11.21]
112250716  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112251192  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
112260284  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112249878  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112252104  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112263967  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112230512  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112219828  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
112219829  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112230565  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112248817  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
112227088  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112251074  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112248671  tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389]
112263074  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112253141  bcl2l11; bcl-2-like protein 11 isoform X2 [KO:K16341]
112255614  bcl-2-like protein 11 isoform X1 [KO:K16341]
112227478  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
112236919  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
112260186  B-cell lymphoma 6 protein [KO:K15618]
112227128  B-cell lymphoma 6 protein isoform X1 [KO:K15618]
121846647  B-cell lymphoma 6 protein homolog [KO:K15618]
112247788  B-cell lymphoma 6 protein-like isoform X1 [KO:K15618]
112257438  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
112253054  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
112214475  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
112236301  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
112240763  ubiquitin-like protein ATG12 [KO:K08336]
112247686  ubiquitin-like protein ATG12 [KO:K08336]
112253764  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112214757  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
112252285  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112229012  gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
112225868  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112238146  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112260042  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
112218377  cat; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
112230404  catalase [KO:K03781] [EC:1.11.1.6]
112265579  catalase [KO:K03781] [EC:1.11.1.6]
112250306  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
112267156  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
112227813  pck2; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
112266975  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112215306  LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112258789  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
112224175  glucose-6-phosphatase catalytic subunit 1-like isoform X1 [KO:K01084] [EC:3.1.3.9]
112224176  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
112236295  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
112224512  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
112223541  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
112257526  interleukin-7 receptor subunit alpha [KO:K05072]
112219510  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
112250790  klf2a; Krueppel-like factor 2 [KO:K17845]
112252192  Krueppel-like factor 2 [KO:K17845]
112239790  Krueppel-like factor 2 [KO:K17845]
112226589  Krueppel-like factor 2 [KO:K17845]
112252084  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
112251541  sphingosine 1-phosphate receptor 1 [KO:K04288]
112250771  sphingosine 1-phosphate receptor 4 [KO:K04293]
112252176  sphingosine 1-phosphate receptor 4 [KO:K04293]
112218685  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
112218682  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
112217736  fbxo25; F-box only protein 25 [KO:K10305]
112241695  F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
otw00010  Glycolysis / Gluconeogenesis
otw00020  Citrate cycle (TCA cycle)
otw00190  Oxidative phosphorylation
otw04010  MAPK signaling pathway
otw04110  Cell cycle
otw04120  Ubiquitin mediated proteolysis
otw04140  Autophagy - animal
otw04210  Apoptosis
otw04350  TGF-beta signaling pathway
otw04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

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