KEGG   PATHWAY: pbi04060
Entry
pbi04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Python bivittatus (Burmese python)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pbi04060  Cytokine-cytokine receptor interaction
pbi04060

Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103059204  C-C motif chemokine 4-like [KO:K12964]
107326181  CCL28; C-C motif chemokine 28 [KO:K05513]
103060149  C-X-C motif chemokine 3-like [KO:K05505]
103060378  interleukin-8-like [KO:K10030]
112541766  CXCL13; C-X-C motif chemokine 13 [KO:K10030]
107326627  alveolar macrophage chemotactic factor-like isoform X1 [KO:K10030]
103067044  C-X-C motif chemokine 11-1-like [KO:K12672]
112541767  interleukin-8-like [KO:K10032]
103061515  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103054463  C-X-C motif chemokine 16 [KO:K10035]
103063709  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
103064841  lymphotactin [KO:K05507]
103054752  IL15; interleukin-15 [KO:K05433]
103064242  EPO; erythropoietin isoform X1 [KO:K05437]
103053760  somatotropin [KO:K05438]
103057526  PRL; prolactin [KO:K05439]
112542478  THPO; thrombopoietin [KO:K06854]
103067892  myelomonocytic growth factor-like [KO:K05423]
103053032  LEP; leptin [KO:K05424]
103067562  IL6; interleukin-6 [KO:K05405]
103058607  IL11; interleukin-11 [KO:K05417]
112540630  interleukin-12 subunit beta-like [KO:K05425]
112542313  interleukin-12 subunit beta-like [KO:K05425]
112540372  IL23A; interleukin-23 subunit alpha [KO:K05426]
112541632  IL27; interleukin-27 subunit alpha [KO:K22629]
103062331  EBI3; interleukin-27 subunit beta isoform X2 [KO:K24476]
103059070  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
103052969  CNTF; ciliary neurotrophic factor [KO:K05420]
103056186  cardiotrophin-1-like isoform X2 [KO:K05422]
103056822  cardiotrophin-2-like [KO:K24382]
103050960  LIF; leukemia inhibitory factor [KO:K05419]
103050412  IL10; interleukin-10 [KO:K05443]
112540106  IL22; interleukin-22 [KO:K05445]
112540279  interferon omega-1-like [KO:K05441]
112540104  interferon gamma-like [KO:K04687]
103055254  IL1B; interleukin-1 beta [KO:K04519]
103064725  interleukin-1 receptor antagonist protein-like [KO:K05481]
103057475  interleukin-1 family member 10-like [KO:K05488]
103051616  interleukin-1 receptor antagonist protein-like [KO:K05488]
103051323  interleukin-18 isoform X1 [KO:K05482]
112542096  interleukin-17F-like [KO:K05494]
103060115  IL17B; interleukin-17B [KO:K05490]
112541048  IL17C; interleukin-17C [KO:K05491]
103061985  IL17D; interleukin-17D [KO:K05492]
112542039  IL25; interleukin-25 [KO:K05493]
103059854  IL16; pro-interleukin-16 [KO:K22628]
103049576  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103052729  tumor necrosis factor-like [KO:K03156]
112540157  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
103051809  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103056295  tumor necrosis factor ligand superfamily member 15-like [KO:K05478]
103056379  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103052237  EDA; ectodysplasin-A isoform X1 [KO:K05480]
103057660  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
103063026  CD40LG; CD40 ligand [KO:K03161]
112540158  uncharacterized protein LOC112540158 [KO:K05472]
103051822  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476]
103064413  TGFB1; transforming growth factor beta-1 [KO:K13375]
103067099  transforming growth factor beta-2-like [KO:K13376]
103063485  TGFB2; transforming growth factor beta-2 [KO:K13376]
103061116  TGFB3; transforming growth factor beta-3 [KO:K13377]
112541743  GDF15; growth/differentiation factor 15 [KO:K05504]
103057125  GDF2; growth/differentiation factor 2 isoform X2 [KO:K05503]
103048192  BMP10; bone morphogenetic protein 10 [KO:K22670]
103048017  INHA; inhibin alpha chain [KO:K05500]
103050207  BMP3; bone morphogenetic protein 3 [KO:K05496]
103048806  growth/differentiation factor 11 [KO:K22679]
103059251  MSTN; growth/differentiation factor 8 [KO:K05497]
103061666  INHBA; inhibin beta A chain [KO:K04667]
103053999  INHBB; inhibin beta B chain [KO:K22687]
103068250  GDF3; growth/differentiation factor 3 [KO:K05495]
103062933  NODAL; nodal homolog [KO:K04666]
103049825  GDF9; growth/differentiation factor 9 [KO:K22673]
103060389  inhibin beta E chain-like [KO:K22689]
103062590  AMH; muellerian-inhibiting factor [KO:K04665]
103059412  BMP2; bone morphogenetic protein 2 [KO:K21283]
103064164  bone morphogenetic protein 2-A-like [KO:K21283]
103054912  BMP4; bone morphogenetic protein 4 [KO:K04662]
103060219  GDF5; growth/differentiation factor 5 [KO:K04664]
103048533  GDF6; growth/differentiation factor 6 [KO:K20012]
103059117  growth/differentiation factor 7 [KO:K20013]
103067097  BMP15; bone morphogenetic protein 15 [KO:K05498]
103056076  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
103067592  BMP6; bone morphogenetic protein 6 [KO:K16620]
103055144  BMP7; bone morphogenetic protein 7 [KO:K16621]
103058384  bone morphogenetic protein 8A [KO:K16622]
103056531  ACKR4; atypical chemokine receptor 4 [KO:K04186]
103056404  CCR7; C-C chemokine receptor type 7 [KO:K04182]
103056465  CCR4; C-C chemokine receptor type 4 [KO:K04179]
103054863  C-C chemokine receptor type 5-like [KO:K04180]
103054628  C-C chemokine receptor type 5-like [KO:K04180]
103053382  CCR10; C-C chemokine receptor type 10 [KO:K04185]
103048542  C-X-C chemokine receptor type 2 [KO:K05050]
103049463  C-X-C chemokine receptor type 3 [KO:K04188]
112541710  C-X-C chemokine receptor type 3-2-like [KO:K04188]
103048374  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
103066628  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103064332  ACKR3; atypical chemokine receptor 3 [KO:K04304]
103057632  CXCR6; C-X-C chemokine receptor type 6 isoform X2 [KO:K04191]
103057871  XCR1; chemokine XC receptor 1 [KO:K04193]
103066608  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
112541087  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103061889  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
103065038  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
103058565  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
112542849  interleukin-9 receptor-like [KO:K05073]
103064799  IL21R; interleukin-21 receptor [KO:K05075]
112541835  cytokine receptor-like factor 2 [KO:K05078]
112541096  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
103051752  interleukin-5 receptor subunit alpha-like isoform X1 [KO:K05066]
103062434  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
103059889  EPOR; erythropoietin receptor [KO:K05079]
103052977  GHR; growth hormone receptor [KO:K05080]
103057862  thrombopoietin receptor isoform X1 [KO:K05082]
112542138  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
103065468  LEPR; leptin receptor [KO:K05062]
103050892  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
112542239  interleukin-6 receptor subunit beta-like [KO:K05060]
103057304  interleukin-6 receptor subunit beta-like [KO:K05060]
112542588  interleukin-31 receptor subunit alpha-like [KO:K05060]
103061645  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
112540224  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
103053316  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
112541592  IL23R; interleukin-23 receptor [KO:K05065]
103051047  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
103052961  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
103066326  ciliary neurotrophic factor receptor subunit alpha-like [KO:K05059]
103054090  LIFR; leukemia inhibitory factor receptor [KO:K05058]
103053699  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
103067073  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103065200  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
112540929  interleukin-20 receptor subunit alpha-like [KO:K05136]
103048387  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
103048905  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
103049141  IFNLR1; interferon lambda receptor 1 isoform X2 [KO:K05140]
103064969  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103063466  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103056914  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103049152  IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133]
112542425  interleukin-1 receptor type 1-like [KO:K04386]
103056190  interleukin-1 receptor accessory protein [KO:K04723]
103067821  interleukin-1 receptor accessory protein-like isoform X1 [KO:K04723]
103053232  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
103059853  interleukin-1 receptor-like 2 [KO:K05172]
103060093  IL18R1; interleukin-18 receptor 1 [KO:K05173]
103060328  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
103049521  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
103054071  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
103049284  IL17RB; interleukin-17 receptor B [KO:K05165]
103054316  IL17RE; interleukin-17 receptor E [KO:K05168]
112540361  T-cell surface glycoprotein CD4-like [KO:K06454]
103051818  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103049228  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
103053956  tumor necrosis factor receptor superfamily member 1B-like [KO:K05141]
103057098  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
103048668  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
103050181  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
103064527  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
103057498  tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
103065227  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
103051261  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
103051899  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
103063431  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103056968  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
103049556  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
103067162  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X2 [KO:K05147]
103061276  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
103064466  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103050211  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
112540417  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
103067316  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X2 [KO:K05150]
107326135  uncharacterized protein LOC107326135 [KO:K05151]
103050615  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
103056674  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
103064130  RELL2; RELT-like protein 2 [KO:K26541]
103050629  RELL1; RELT-like protein 1 [KO:K26541]
103059881  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
103057562  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103063579  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103063037  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
103055188  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
103060123  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
103067229  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
103063353  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
103048675  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
103049229  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
103053590  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
103063746  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
103058301  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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