KEGG   PATHWAY: pcad04144
Entry
pcad04144                   Pathway                                
Name
Endocytosis - Physeter catodon (sperm whale)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pcad04144  Endocytosis
pcad04144

Other DBs
GO: 0006897
Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
112067148  ADP-ribosylation factor 6 isoform X2 [KO:K07941]
102990690  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102988075  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
102973790  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
102990868  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
102978946  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102986218  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102977482  dynamin-3 [KO:K01528] [EC:3.6.5.5]
114483869  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
102989343  DNM1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
102991476  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
114484958  dynamin-2-like [KO:K23484] [EC:3.6.5.5]
102988893  CLTA; clathrin light chain A isoform X8 [KO:K04644]
102985112  CLTB; clathrin light chain B isoform X1 [KO:K04645]
102987265  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
114483887  AP-2 complex subunit alpha-1 [KO:K11824]
102980743  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
102976240  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
102978548  AP2B1; AP-2 complex subunit beta [KO:K11825]
102973393  AP2M1; AP-2 complex subunit mu [KO:K11826]
102990597  AP2S1; AP-2 complex subunit sigma [KO:K11827]
102984579  AP-2 complex subunit sigma-like [KO:K11827]
102994402  EH domain-containing protein 2 [KO:K12469]
102978050  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102995949  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102990094  ZFYVE9; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9 [KO:K04679]
102988528  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
102983450  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102978015  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
102989819  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
102985437  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102982044  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102982240  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114483863  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102994124  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
102980192  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
102995121  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
102977116  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X9 [KO:K12470]
102981589  SH3GL3; endophilin-A3 [KO:K11247]
102996847  endophilin-A2 [KO:K11247]
102981809  SH3GL2; endophilin-A1 [KO:K11247]
102976701  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
102982526  myc box-dependent-interacting protein 1 [KO:K12562]
114487309  BIN1; myc box-dependent-interacting protein 1 [KO:K12562]
102978953  AMPH; amphiphysin [KO:K12562]
102996244  EPN3; epsin-3 isoform X6 [KO:K12471]
102983760  EPN2; epsin-2 isoform X1 [KO:K12471]
102989345  EPN1; epsin-1 isoform X1 [KO:K12471]
102979648  EPS15; epidermal growth factor receptor substrate 15 isoform X2 [KO:K12472]
102995150  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
102973189  SPART; spartin isoform X1 [KO:K19366]
102993845  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102995919  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X11 [KO:K13305] [EC:2.3.2.26]
102980125  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102993207  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
102978576  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
102982983  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
102988231  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
102995467  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
102990840  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
102984457  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102987879  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
102988057  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
112064940  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102995584  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
102995856  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050]
102989559  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102981560  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102995100  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102996848  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
114485015  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
102978788  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
102988242  GRK4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
102988311  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
102979868  G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
102986742  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
102984518  ARRB1; beta-arrestin-1 [KO:K04439]
102981146  WASL; LOW QUALITY PROTEIN: actin nucleation-promoting factor WASL [KO:K23612]
102983608  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
102994897  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102984528  actin-related protein 3 isoform X1 [KO:K18584]
102981282  LOW QUALITY PROTEIN: actin-related protein 3-like [KO:K18584]
102995811  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X2 [KO:K05757]
102996647  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X3 [KO:K05757]
102986342  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
102994582  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
102991986  actin-related protein 2/3 complex subunit 2 [KO:K05758]
112065100  ARPC2; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2 [KO:K05758]
102994479  actin-related protein 2/3 complex subunit 2 [KO:K05758]
102984263  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102975714  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102987316  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102995014  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102997003  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5-like [KO:K05754]
102987994  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
102982234  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
102978035  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
102982689  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
102974358  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102994908  heat shock 70 kDa protein 1B [KO:K03283]
102995190  heat shock 70 kDa protein 1B [KO:K03283]
102995465  heat shock 70 kDa protein 1-like [KO:K03283]
102989030  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102990601  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102983803  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102973375  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102986227  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102996800  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
102979993  WASHC4; WASH complex subunit 4 [KO:K18465]
102996844  WASHC5; WASH complex subunit 5 [KO:K18464]
102974617  WASH complex subunit 2 [KO:K18462]
102988365  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
102991419  WASHC3; WASH complex subunit 3 [KO:K18463]
102990902  WASH complex subunit 3-like [KO:K18463]
102987297  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
112064330  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
102978759  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
102987809  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
102988639  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
102978446  CAPZB; F-actin-capping protein subunit beta isoform X3 [KO:K10365]
102982747  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
102986426  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
102984147  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
102995418  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
102985089  SNX3; sorting nexin-3 [KO:K17918]
102980488  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
102992320  sorting nexin-3-like [KO:K17918]
102985080  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X4 [KO:K11839] [EC:3.4.19.12]
102981455  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
102976905  RAB7A; ras-related protein Rab-7a [KO:K07897]
102993663  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
102978849  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
102988931  STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705]
102981758  LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein-like [KO:K12183]
102977146  TSG101; tumor susceptibility gene 101 protein isoform X3 [KO:K12183]
102986391  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
102986753  multivesicular body subunit 12B [KO:K12186]
102993473  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
102985565  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
102980061  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
102982041  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
102989435  VPS37B; vacuolar protein sorting-associated protein 37B isoform X3 [KO:K12185]
102981479  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
102996936  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
102993370  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
102996178  CHMP6; charged multivesicular body protein 6 [KO:K12195]
102992935  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
102975629  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
102984894  CHMP3; charged multivesicular body protein 3 [KO:K12193]
102976865  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
102992919  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
102980529  CHMP7; charged multivesicular body protein 7 isoform X4 [KO:K15053]
102976814  VPS4A; vacuolar protein sorting-associated protein 4A isoform X2 [KO:K12196]
102986996  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
102986035  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
102976790  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
102996746  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
102980294  charged multivesicular body protein 1B2 isoform X2 [KO:K12197]
102996861  CHMP5; charged multivesicular body protein 5 [KO:K12198]
102978971  IST1; IST1 homolog [KO:K19476]
102991029  LOW QUALITY PROTEIN: IST1 homolog [KO:K19476]
102978625  PDCD6IP; programmed cell death 6-interacting protein isoform X2 [KO:K12200]
102992638  SPG21; maspardin [KO:K19367]
102982311  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
102992715  SNX2; sorting nexin-2 [KO:K17917]
102988655  SNX1; sorting nexin-1 isoform X3 [KO:K17917]
102993319  SNX5; sorting nexin-5 isoform X5 [KO:K17920]
102995609  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
102976127  SNX32; sorting nexin-32 isoform X2 [KO:K17920]
102983882  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102974550  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102995923  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102979617  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
102983639  RHOA; transforming protein RhoA [KO:K04513]
112064291  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
112064292  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112064318  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
102996245  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102985933  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
102995829  folate receptor alpha [KO:K13649]
102996106  FOLR2; folate receptor beta [KO:K13649]
102995560  folate receptor alpha isoform X1 [KO:K13649]
102978243  CAV1; caveolin-1 isoform X1 [KO:K06278]
102977968  CAV2; caveolin-2 [KO:K12958]
102991626  CAV3; caveolin-3 [KO:K12959]
112064949  caveolin-3-like [KO:K12959]
102980827  EHD3; EH domain-containing protein 3 [KO:K12476]
102991318  EHD4; EH domain-containing protein 4 [KO:K12477]
102983124  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
102984481  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
102973277  RAB5B; ras-related protein Rab-5B [KO:K07888]
102984866  RAB5C; ras-related protein Rab-5C [KO:K07889]
102992916  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
102996586  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
102976166  RAB4A; ras-related protein Rab-4A isoform X2 [KO:K07879]
102985920  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
102991050  RUFY2; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 2 [KO:K12482]
102992197  EHD1; EH domain-containing protein 1 [KO:K12483]
102987785  VPS45; vacuolar protein sorting-associated protein 45 isoform X2 [KO:K12479]
102976538  SNX4; sorting nexin-4 [KO:K17919]
102990989  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
102994395  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
102973184  RAB10; ras-related protein Rab-10 [KO:K07903]
102993114  RAB8A; ras-related protein Rab-8A isoform X2 [KO:K07901]
102978487  RAB35; ras-related protein Rab-35 isoform X2 [KO:K07876]
102978590  RAB11A; ras-related protein Rab-11A isoform X2 [KO:K07904]
102993498  RAB11B; ras-related protein Rab-11B [KO:K07905]
102982039  RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484]
102982141  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
102995633  RAB11FIP1; rab11 family-interacting protein 1 isoform X4 [KO:K12484]
102975431  ZFYVE27; protrudin isoform X1 [KO:K19368]
102981918  KIF5A; kinesin heavy chain [KO:K10396]
102976660  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102993084  KIF5C; kinesin heavy chain [KO:K10396]
102996725  RAB11FIP4; rab11 family-interacting protein 4 [KO:K12485]
102984403  rab11 family-interacting protein 3 [KO:K12485]
102990471  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
102981214  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102994511  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
102974585  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
102988631  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
102982085  PRKCI; protein kinase C iota type isoform X3 [KO:K06069] [EC:2.7.11.13]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102979538  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
102984770  SMAP1; stromal membrane-associated protein 1 isoform X2 [KO:K12486]
102991814  GIT1; ARF GTPase-activating protein GIT1 isoform X5 [KO:K05737]
102975570  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
102982090  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
102979871  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
102973503  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
102990850  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4 [KO:K12489]
102994386  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
102989464  ACAP3; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
102983743  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K18439]
102985571  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
102979637  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
102992226  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
102988499  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
102986096  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
102996021  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
102992513  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
102995958  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
102978372  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
102976826  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
102984096  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
102993159  PSD3; PH and SEC7 domain-containing protein 3 isoform X5 [KO:K12494]
102994550  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X3 [KO:K12495]
102993341  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
102975546  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
102990707  CYTH1; cytohesin-1 isoform X2 [KO:K18441]
102991011  CYTH3; cytohesin-3 isoform X2 [KO:K18441]
102992963  CYTH2; cytohesin-2 [KO:K18441]
102990288  CYTH4; cytohesin-4 [KO:K18441]
102986368  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
102982233  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2 [KO:K18442]
102982593  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
102987040  ADP-ribosylation factor 1 [KO:K07937]
102994410  ADP-ribosylation factor 2 [KO:K07937]
102984837  ADP-ribosylation factor 1-like [KO:K07937]
102984094  ARF3; ADP-ribosylation factor 3 [KO:K07938]
102996492  ARF4; ADP-ribosylation factor 4 [KO:K07939]
112066254  LOW QUALITY PROTEIN: ADP-ribosylation factor 4-like [KO:K07939]
102987229  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pcad04060  Cytokine-cytokine receptor interaction
pcad04070  Phosphatidylinositol signaling system
pcad04130  SNARE interactions in vesicular transport
pcad04142  Lysosome
pcad04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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