KEGG   PATHWAY: pcad04060
Entry
pcad04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Physeter macrocephalus (sperm whale)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pcad04060  Cytokine-cytokine receptor interaction
pcad04060

Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973226  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102973496  [KO:K04736]
102973585  IL10; interleukin-10 [KO:K05443]
102973670  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
102973768  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102973842  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102973875  IL19; interleukin-19 [KO:K05444]
102974009  OSM; oncostatin-M [KO:K05418]
102974041  CD40LG; CD40 ligand [KO:K03161]
102974160  GDF5; growth/differentiation factor 5 [KO:K04664]
102974232  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
102974293  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
102974550  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102974635  IL20; interleukin-20 isoform X1 [KO:K22667]
102974910  IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172]
102975019  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102975052  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
102975127  CCL16; C-C motif chemokine 16 [KO:K21093]
102975234  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476]
102975366  RELL1; RELT-like protein 1 isoform X2 [KO:K26541]
102975470  IL36RN; interleukin-36 receptor antagonist protein isoform X1 [KO:K05483]
102975625  CCL5; C-C motif chemokine 5 [KO:K12499]
102975643  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
102975734  OSMR; oncostatin-M-specific receptor subunit beta isoform X3 [KO:K05057]
102975759  [KO:K05481]
102975779  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
102975844  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
102975864  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
102975928  INHBA; inhibin beta A chain [KO:K04667]
102976118  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
102976160  PRL; LOW QUALITY PROTEIN: prolactin [KO:K05439]
102976276  INHA; inhibin alpha chain [KO:K05500]
102976313  IL18; interleukin-18 [KO:K05482]
102976328  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
102976516  [KO:K10035]
102976532  [KO:K05488]
102976534  IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168]
102976783  IL7; interleukin-7 [KO:K05431]
102977028  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X3 [KO:K05138]
102977303  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102977317  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
102977345  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102977643  IL17B; interleukin-17B isoform X2 [KO:K05490]
102977652  IL17RC; interleukin-17 receptor C isoform X3 [KO:K05166]
102977854  IFNLR1; interferon lambda receptor 1 [KO:K05140]
102977875  IL24; interleukin-24 [KO:K22668]
102977921  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102977947  IL15; interleukin-15 isoform X1 [KO:K05433]
102978050  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102978087  CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
102978396  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
102978432  THPO; thrombopoietin isoform X2 [KO:K06854]
102978572  LIF; leukemia inhibitory factor [KO:K05419]
102978631  BMP2; bone morphogenetic protein 2 [KO:K21283]
102978647  GDF11; growth/differentiation factor 11 [KO:K22679]
102978796  GDF10; growth/differentiation factor 10 [KO:K22674]
102978826  INHBC; inhibin beta C chain [KO:K22688]
102978902  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
102978940  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
102978976  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
102979011  [KO:K05487]
102979075  GDF2; growth/differentiation factor 2 [KO:K05503]
102979109  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102979111  INHBE; inhibin beta E chain [KO:K22689]
102979127  [KO:K05438]
102979165  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
102979276  [KO:K05484]
102979459  IFNE; interferon epsilon [KO:K05442]
102979472  [KO:K04722]
102979506  GDF6; growth/differentiation factor 6 [KO:K20012]
102979515  IL17F; interleukin-17F isoform X2 [KO:K05494]
102979564  [KO:K05486]
102979614  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
102979617  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
102979729  [KO:K05440]
102979808  CXCL13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102979901  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102979960  CXCL8; interleukin-8 [KO:K10030]
102979991  IL17A; interleukin-17A isoform X2 [KO:K05489]
102980036  [KO:K04722]
102980126  IL6; interleukin-6 [KO:K05405]
102980143  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102980207  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
102980225  RELL2; RELT-like protein 2 [KO:K26541]
102980255  [KO:K05506]
102980314  [KO:K05414]
102980451  EPOR; erythropoietin receptor [KO:K05079]
102980548  PPBP; platelet basic protein [KO:K10029]
102980587  IL12B; interleukin-12 subunit beta [KO:K05425]
102980613  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102980818  [KO:K05407]
102980890  CD27; CD27 antigen isoform X1 [KO:K05144]
102980945  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
102980969  CCL28; C-C motif chemokine 28 [KO:K05513]
102981211  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
102981280  IL26; LOW QUALITY PROTEIN: interleukin-26 [KO:K05446]
102981286  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102981375  [KO:K05505]
102981533  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
102981535  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
102981551  IFNG; interferon gamma [KO:K04687]
102981557  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102981762  EPO; erythropoietin [KO:K05437]
102981863  IL23A; interleukin-23 subunit alpha [KO:K05426]
102982035  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
102982113  IL22; interleukin-22 [KO:K05445]
102982190  IL11; interleukin-11 [KO:K05417]
102982237  IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060]
102982314  [KO:K05505]
102982335  IL12A; interleukin-12 subunit alpha [KO:K05406]
102982488  IL17RB; interleukin-17 receptor B [KO:K05165]
102982565  PRLR; prolactin receptor [KO:K05081]
102982610  LTB; lymphotoxin-beta isoform X1 [KO:K03157]
102982830  GDF3; growth/differentiation factor 3 [KO:K22672]
102982876  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
102982921  CCL21; C-C motif chemokine 21 [KO:K16062]
102983052  IL27; interleukin-27 subunit alpha [KO:K22629]
102983069  TNF; tumor necrosis factor [KO:K03156]
102983071  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
102983189  [KO:K16598]
102983204  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
102983351  IL5; interleukin-5 [KO:K05428]
102983483  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
102983602  MSTN; growth/differentiation factor 8 [KO:K05497]
102983663  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
102983830  LTA; lymphotoxin-alpha [KO:K05468]
102983897  IL4; interleukin-4 [KO:K05430]
102984380  [KO:K04177]
102984448  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
102984762  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102984800  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
102984980  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
102985030  IL21R; interleukin-21 receptor [KO:K05075]
102985097  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102985338  BMP3; bone morphogenetic protein 3 [KO:K05496]
102985552  CX3CR1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
102985929  [KO:K05507]
102986029  NODAL; nodal homolog [KO:K04666]
102986040  IL34; interleukin-34 isoform X1 [KO:K22633]
102986197  [KO:K05507]
102986211  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
102986378  IFNK; interferon kappa [KO:K05441]
102986525  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
102986636  BMP10; bone morphogenetic protein 10 [KO:K22670]
102986740  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
102986774  ACKR4; atypical chemokine receptor 4 [KO:K04186]
102986990  CCL24; LOW QUALITY PROTEIN: C-C motif chemokine 24 [KO:K21097]
102987016  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
102987260  LIFR; leukemia inhibitory factor receptor [KO:K05058]
102987302  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102987412  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102987429  CNTF; ciliary neurotrophic factor [KO:K05420]
102987438  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
102988264  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102988298  BMP6; bone morphogenetic protein 6 [KO:K16620]
102988377  TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X2 [KO:K05475]
102988416  GDF7; growth/differentiation factor 7 [KO:K20013]
102988430  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
102988439  [KO:K22669]
102988466  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
102988623  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
102988651  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
102988669  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
102988934  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
102988948  [KO:K05440]
102989038  IL9; interleukin-9 [KO:K05432]
102989117  ACKR3; atypical chemokine receptor 3 [KO:K04304]
102989225  [KO:K05474]
102989473  IL33; interleukin-33 [KO:K12967]
102989482  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102989522  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
102989537  [KO:K16596]
102989542  IL13; interleukin-13 [KO:K05435]
102989559  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102989891  [KO:K05440]
102990044  IL17RA; interleukin-17 receptor A [KO:K05164]
102990067  [KO:K14624]
102990097  CXCL12; stromal cell-derived factor 1 [KO:K10031]
102990155  IFNB1; interferon beta [KO:K05415]
102990229  TNFSF18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479]
102990305  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
102990319  EDA; ectodysplasin-A isoform X1 [KO:K05480]
102990393  IL21; interleukin-21 [KO:K05434]
102990481  [KO:K05424]
102990617  [KO:K05511]
102990654  IL2; interleukin-2 [KO:K05429]
102990857  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
102990890  [KO:K21092]
102990962  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
102990991  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
102991034  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102991223  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X2 [KO:K05063]
102991425  [KO:K16622]
102991507  ACVR2B; activin receptor type-2B isoform X3 [KO:K13596] [EC:2.7.11.30]
102991572  [KO:K05064]
102991643  ACVR1C; activin receptor type-1C isoform X2 [KO:K13568] [EC:2.7.11.30]
102991717  CCL19; C-C motif chemokine 19 [KO:K05512]
102991726  XCR1; chemokine XC receptor 1 [KO:K04193]
102991987  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
102992121  IL23R; interleukin-23 receptor [KO:K05065]
102992256  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102992337  IL25; LOW QUALITY PROTEIN: interleukin-25 [KO:K05493]
102992377  [KO:K24382]
102992458  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
102992483  CX3CL1; fractalkine isoform X2 [KO:K05508]
102992548  CCL1; C-C motif chemokine 1 [KO:K05514]
102992721  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
102992737  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102992780  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
102992873  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102992913  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
102992954  CCL22; C-C motif chemokine 22 [KO:K21095]
102993033  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102993158  MPL; thrombopoietin receptor [KO:K05082]
102993283  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
102993287  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102993567  CXCL11; C-X-C motif chemokine 11 isoform X2 [KO:K12672]
102993681  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
102993910  IL1A; interleukin-1 alpha [KO:K04383]
102994042  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
102994188  IL1B; interleukin-1 beta [KO:K04519]
102994266  GDF15; growth/differentiation factor 15 [KO:K05504]
102994287  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
102994451  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102994902  [KO:K24476]
102994952  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102995272  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
102995313  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
102995501  BMP7; bone morphogenetic protein 7 isoform X2 [KO:K16621]
102995584  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
102995650  [KO:K05073]
102995814  CD70; LOW QUALITY PROTEIN: CD70 antigen [KO:K05470]
102995856  [KO:K05050]
102995909  CCR6; C-C chemokine receptor type 6 [KO:K04181]
102995923  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102995949  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102996095  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
102996195  [KO:K05408]
102996201  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
102996314  GHR; growth hormone receptor isoform X2 [KO:K05080]
102996324  LEPR; leptin receptor [KO:K05062]
102996463  [KO:K12964]
102996539  AMHR2; anti-Muellerian hormone type-2 receptor isoform X6 [KO:K04672] [EC:2.7.11.30]
102996644  AMH; muellerian-inhibiting factor [KO:K04665]
102996703  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
102996782  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
102996862  [KO:K05090] [EC:2.7.10.1]
102996969  BMP15; bone morphogenetic protein 15 [KO:K05498]
102997040  IFNGR2; interferon gamma receptor 2 isoform X2 [KO:K05133]
112062060  [KO:K05505]
112062510  INHBB; inhibin beta B chain [KO:K22687]
112064825  CTF1; cardiotrophin-1 isoform X3 [KO:K05422]
112064940  CCR5; C-C chemokine receptor type 5 [KO:K04180]
112065207  IL17C; interleukin-17C isoform X1 [KO:K05491]
112065317  [KO:K16622]
112065321  CCL26; LOW QUALITY PROTEIN: C-C motif chemokine 26 [KO:K21096]
112065399  IL17D; interleukin-17D [KO:K05492]
112065745  [KO:K05440]
112065747  [KO:K05414]
112065887  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
112065964  [KO:K10035]
112065981  [KO:K05408]
112066196  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
112066353  [KO:K05424]
114486512  [KO:K13567] [EC:2.7.11.30]
114487561  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
129391332  [KO:K16597]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
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Evolutionary divergence and functions of the human interleukin (IL) gene family.
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Hum Genomics 5:30-55 (2010)
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Reference
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  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
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Reference
PMID:15500860
  Authors
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  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
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Adv Protein Chem 68:107-46 (2004)
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Reference
PMID:16034365
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  Title
Interleukin-1 and neuronal injury.
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Nat Rev Immunol 5:629-40 (2005)
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Reference
PMID:23847622
  Authors
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  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
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Immunity 34:149-62 (2011)
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Reference
PMID:17530315
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Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
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Basic Res Cardiol 102:279-97 (2007)
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Reference
PMID:24381786
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Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
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Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
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ko04060   

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