KEGG   PATHWAY: pgeo04144
Entry
pgeo04144                   Pathway                                
Name
Endocytosis - Pseudochaenichthys georgianus (South Georgia icefish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pgeo04144  Endocytosis
pgeo04144

Other DBs
GO: 0006897
Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117467639  arf6b; ADP-ribosylation factor 6b [KO:K07941]
117439726  arf6a; ADP-ribosylation factor 6a [KO:K07941]
117460781  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117461710  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117455655  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117456379  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117445892  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117452615  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117456348  pip5kl1; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
117451983  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
117465895  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
117467667  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
117458652  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117462111  dnm3b; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
117456201  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
117445338  dnm3a; dynamin 3a isoform X1 [KO:K01528] [EC:3.6.5.5]
117464720  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
117450658  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
117439362  clta; clathrin light chain A isoform X1 [KO:K04644]
117453715  cltb; clathrin light chain B isoform X1 [KO:K04645]
117458283  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
117457183  clathrin heavy chain 1 isoform X1 [KO:K04646]
117452014  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
117462276  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
117443024  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
117458302  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
117462134  AP-2 complex subunit mu-A isoform X1 [KO:K11826]
117457418  ap2s1; AP-2 complex subunit sigma [KO:K11827]
117457925  EH domain-containing protein 2-like [KO:K12469]
117457081  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
117461426  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117455145  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117441190  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117461751  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
117455975  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
117445061  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
117453143  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2-like [KO:K04500]
117464805  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
117448076  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117465616  tfr1b; transferrin receptor 1b [KO:K06503]
117461886  transferrin receptor protein 1-like isoform X1 [KO:K06503]
117462222  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117445902  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117459568  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117457202  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
117467594  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117458594  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117448090  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117457166  cbl; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
117458294  cblb; E3 ubiquitin-protein ligase CBL-B-B isoform X1 [KO:K22517] [EC:2.3.2.27]
117460479  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
117465576  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
117462163  endophilin-A2-like isoform X1 [KO:K11247]
117462389  endophilin-A3-like [KO:K11247]
117449260  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
117443076  endophilin-A1-like [KO:K11247]
117445279  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
117465695  sh3glb1a; endophilin-B1a [KO:K11248]
117468220  endophilin-B1-like isoform X1 [KO:K11248]
117456549  endophilin-B2-like isoform X1 [KO:K21269]
117452507  endophilin-B2-like isoform X1 [KO:K21269]
117466755  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
117460293  epn1; epsin-1 isoform X1 [KO:K12471]
117454545  epn3b; epsin-3 isoform X1 [KO:K12471]
117451124  epn3a; epsin-3 isoform X1 [KO:K12471]
117451255  epn2; epsin-2 isoform X1 [KO:K12471]
117461716  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
117461784  uncharacterized protein LOC117461784 isoform X1 [KO:K12472]
117445256  eps15l1a; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
117446038  eps15; epidermal growth factor receptor substrate 15 [KO:K12472]
117458513  sparta; spartin a isoform X1 [KO:K19366]
117457242  spartb; spartin b isoform X1 [KO:K19366]
117455777  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117439283  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117463949  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117443182  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
117449012  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
117446671  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
117447143  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117450948  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117451746  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
117465463  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
117444886  LOW QUALITY PROTEIN: low-density lipoprotein receptor-like [KO:K12473]
117446187  ldlrb; low-density lipoprotein receptor [KO:K12473]
117467622  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
117463684  si:dkey-19b23.8; protein FAM43A [KO:K12474]
117455650  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
117439534  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
117455956  dab2; disabled homolog 2 isoform X1 [KO:K12475]
117466340  cxcr2; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 1 [KO:K05050]
117466803  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
117459082  C-X-C chemokine receptor type 1-like [KO:K05050]
117459090  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
117466620  C-X-C chemokine receptor type 4-like [KO:K04189]
117462457  C-X-C chemokine receptor type 4-like [KO:K04189]
117466282  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
117462788  grk7a; LOW QUALITY PROTEIN: rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
117458887  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
117457041  rhodopsin kinase grk7a-like [KO:K00909] [EC:2.7.11.14]
117458434  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
117440847  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
117451587  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
117452316  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
117463563  arrb2b; arrestin, beta 2b [KO:K04439]
117458360  arrestin red cell isoform X1 [KO:K04439]
117442083  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
117439285  waslb; LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor b [KO:K23612]
117459347  actin-related protein 2-B-like [KO:K17260]
117463359  zgc:101810; actin-related protein 2 [KO:K17260]
117450517  actin-related protein 2-B [KO:K17260]
117466551  actin-related protein 3-like [KO:K18584]
117457723  actin-related protein 3 [KO:K18584]
117440828  actin-related protein 3-like [KO:K18584]
117447726  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117447735  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117451496  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
117459122  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117456689  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117447208  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
117446719  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117445356  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117459438  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
117454735  wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
117450897  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
117460458  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
117459080  hspa8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
117457911  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
117448856  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
117450714  heat shock 70 kDa protein 1 [KO:K03283]
117445528  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
117448223  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
117461207  washc5; WASH complex subunit 5 [KO:K18464]
117459637  washc2c; WASH complex subunit 2A isoform X1 [KO:K18462]
117448229  wash1; WASH complex subunit 1 [KO:K18461]
117468433  washc3; WASH complex subunit 3 [KO:K18463]
117447168  F-actin-capping protein subunit alpha-1 [KO:K10364]
117449154  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
117446825  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
117468218  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
117439281  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
117458287  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
117456948  vacuolar protein sorting-associated protein 26B-like isoform X1 [KO:K18466]
117462182  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
117458414  snx12; sorting nexin-12 [KO:K17918]
117439975  snx3; sorting nexin-3 [KO:K17918]
117465186  usp8; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
117452718  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
117446095  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
117446650  ras-related protein rab7-like [KO:K07897]
117446760  rab7a; ras-related protein Rab-7a [KO:K07897]
117451002  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
117466769  stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
117448192  tsg101a; tumor susceptibility 101a [KO:K12183]
117456218  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
117452005  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
117453565  mvb12a; multivesicular body subunit 12A [KO:K12186]
117455572  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
117468159  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
117458158  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
117456993  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
117443321  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
117443322  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
117443323  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
117444814  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
117464638  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
117458395  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
117464809  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
117464998  chmp6b; charged multivesicular body protein 6 [KO:K12195]
117451269  charged multivesicular body protein 6-like [KO:K12195]
117449819  charged multivesicular body protein 4c [KO:K12194]
117450127  charged multivesicular body protein 4c-like [KO:K12194]
117446502  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
117443343  chmp4c; charged multivesicular body protein 4c [KO:K24782]
117467675  chmp3; charged multivesicular body protein 3 [KO:K12193]
117464639  chmp2a; charged multivesicular body protein 2a [KO:K12191]
117466644  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
117442380  chmp7; charged multivesicular body protein 7 [KO:K15053]
117462715  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
117449757  vps4a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4A [KO:K12196]
117444627  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
117453955  charged multivesicular body protein 1b-like [KO:K12197]
117458321  charged multivesicular body protein 1b [KO:K12197]
117449280  charged multivesicular body protein 1a-like [KO:K12197]
117449281  charged multivesicular body protein 1a isoform X1 [KO:K12197]
117465758  chmp5b; charged multivesicular body protein 5 [KO:K12198]
117462676  chmp5a; charged multivesicular body protein 5 [KO:K12198]
117466773  ist1; IST1 homolog isoform X1 [KO:K19476]
117454980  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
117467346  spg21; maspardin [KO:K19367]
117439736  igf2r; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
117464510  sorting nexin-1-like [KO:K17917]
117447504  snx1a; sorting nexin-1a [KO:K17917]
117452053  snx2; sorting nexin-2 [KO:K17917]
117459891  snx5; sorting nexin-5 [KO:K17920]
117447130  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
117449444  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117446643  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117448041  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117442896  APC membrane recruitment protein 1-like isoform X1 [KO:K05069]
117442898  cytokine receptor common subunit beta-like [KO:K05069]
117451130  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
117449082  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117450100  rho-related GTP-binding protein RhoA-D [KO:K04513]
117450101  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117450179  rho-related GTP-binding protein RhoA-C [KO:K04513]
117446482  rho-related GTP-binding protein RhoA-B [KO:K04513]
117454944  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117443521  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
117457415  folr; folate receptor [KO:K13649]
117451137  rtbdn; retbindin [KO:K13649]
117448133  cav1; caveolin-1 [KO:K06278]
117447066  zgc:172270; caveolin-2 [KO:K12958]
117448164  cav2; caveolin-2 [KO:K12958]
117450159  zgc:158296; caveolin-2 isoform X1 [KO:K12958]
117446174  caveolin-2-like [KO:K12958]
117446173  cav3; caveolin-3 [KO:K12959]
117439740  ehd3; EH domain-containing protein 3 [KO:K12476]
117467788  ehd4; EH domain-containing protein 4 [KO:K12477]
117447852  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
117460554  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
117455002  ras-related protein Rab-5A-like [KO:K07887]
117443578  rab5b; ras-related protein Rab-5B [KO:K07888]
117464962  ras-related protein Rab-5C-like [KO:K07889]
117451151  rab5c; ras-related protein Rab-5C [KO:K07889]
117458854  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
117449090  rabenosyn-5 [KO:K12481]
117463553  rab4a; ras-related protein Rab-4A [KO:K07879]
117439309  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
117453555  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
117453699  EH domain-containing protein 1-like [KO:K12483]
117453391  EH domain-containing protein 1-like [KO:K12483]
117466640  sorting nexin-4-like [KO:K17919]
117468295  sorting nexin-4-like [KO:K17919]
117462230  rab31; ras-related protein Rab-31 [KO:K07891]
117447031  rab22a; ras-related protein Rab-22A [KO:K07891]
117462036  ras-related protein Rab-8A-like [KO:K07901]
117445384  ras-related protein Rab-8A [KO:K07901]
117443274  rab35b; ras-related protein Rab-35b [KO:K07876]
117450766  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
117463106  rab11a; ras-related protein Rab-11A [KO:K07904]
117462077  ras-related protein Rab-11B-like [KO:K07905]
117445307  ras-related protein Rab-11B [KO:K07905]
117445629  ras-related protein Rab-11B-like [KO:K07905]
117459689  rab11 family-interacting protein 2 [KO:K12484]
117467527  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
117454116  rab11 family-interacting protein 1 isoform X1 [KO:K12484]
117451838  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
117461746  zfyve27; protrudin isoform X1 [KO:K19368]
117465730  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
117461809  kinesin-1 heavy chain-like [KO:K10396]
117457576  kinesin heavy chain-like [KO:K10396]
117449910  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
117446351  kif5ab; kinesin heavy chain [KO:K10396]
117464532  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
117451551  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
117446476  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
117466036  pard3aa; partitioning defective 3 homolog [KO:K04237]
117455085  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
117447675  pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
117449464  pard6b; LOW QUALITY PROTEIN: partitioning defective 6 homolog beta [KO:K06093]
117449019  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117462403  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117460934  cdc42l; cell division cycle 42, like [KO:K04393]
117454985  cell division control protein 42 homolog [KO:K04393]
117448852  cell division control protein 42 homolog isoform X1 [KO:K04393]
117443153  cell division control protein 42 homolog isoform X1 [KO:K04393]
117460179  stromal membrane-associated protein 1-like [KO:K12486]
117455119  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
117457281  stromal membrane-associated protein 1-like [KO:K12486]
117457145  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
117456061  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
117453054  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
117467627  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
117467705  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12488]
117465498  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
117446959  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
117464069  acap1; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
117449209  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
117446030  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
117446255  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
117457750  LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
117463485  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
117462359  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
117449540  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
117446166  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
117446204  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
117463203  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
117439144  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
117464347  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
117454152  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
117456133  PH and SEC7 domain-containing protein 4 [KO:K12494]
117441897  uncharacterized protein LOC117441897 [KO:K12494]
117439228  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
117448657  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
117448862  iqsec2b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
117449601  iqsec1a; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
117449642  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
117443900  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
117460779  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
117464307  cyth3a; cytohesin-3 [KO:K18441]
117465041  cyth1b; LOW QUALITY PROTEIN: cytohesin-1b [KO:K18441]
117450539  cyth3b; cytohesin-3 [KO:K18441]
117450889  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
117451497  cytohesin-4-like [KO:K18441]
117451584  cytohesin-3-like isoform X1 [KO:K18441]
117448925  arfgef2; LOW QUALITY PROTEIN: brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
117444902  LOW QUALITY PROTEIN: brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
117459596  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
117462791  arf1; ADP-ribosylation factor 1 [KO:K07937]
117464669  arf2b; ADP-ribosylation factor 2b [KO:K07937]
117450962  arf2a; ADP-ribosylation factor 2a [KO:K07937]
117447170  ADP-ribosylation factor 3-like [KO:K07938]
117449703  arf3a; ADP-ribosylation factor 3a [KO:K07938]
117448046  ADP-ribosylation factor 4 [KO:K07939]
117447087  ADP-ribosylation factor 1-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pgeo04060  Cytokine-cytokine receptor interaction
pgeo04070  Phosphatidylinositol signaling system
pgeo04130  SNARE interactions in vesicular transport
pgeo04142  Lysosome
pgeo04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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