KEGG   PATHWAY: pmur04820
Entry
pmur04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Protobothrops mucrosquamatus (Taiwan habu)
Class
Cellular Processes; Cell motility
Pathway map
pmur04820  Cytoskeleton in muscle cells
pmur04820

Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107282605  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
107291014  collagen alpha-1(I) chain [KO:K06236]
107283645  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
107288423  COL3A1; collagen alpha-1(III) chain [KO:K19720]
107288434  COL5A2; collagen alpha-2(V) chain [KO:K19721]
107295915  collagen alpha-1(V) chain [KO:K19721]
107298986  collagen alpha-2(XI) chain-like [KO:K19721]
107292301  collagen alpha-1(XI) chain [KO:K19721]
107290143  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
107290209  collagen alpha-1(XI) chain-like [KO:K19721]
114923236  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
107284773  DCN; decorin [KO:K04660]
107303335  VCAN; versican core protein [KO:K06793]
107296179  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
107296188  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
107286071  collagen alpha-6(VI) chain-like [KO:K06238]
107291711  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
107286068  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
107286069  collagen alpha-6(VI) chain [KO:K06238]
107296464  THBS1; thrombospondin-1 [KO:K16857]
107296697  THBS3; thrombospondin-3 [KO:K04659]
107293307  THBS2; thrombospondin-2 [KO:K04659]
107300595  THBS4; thrombospondin-4 [KO:K04659]
107282855  COMP; cartilage oligomeric matrix protein [KO:K04659]
107287690  FBN1; fibrillin-1 [KO:K06825]
107289734  LOW QUALITY PROTEIN: fibrillin-2 [KO:K23342]
107287766  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107284270  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107303140  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
107303151  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
107284271  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107286669  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
107292273  fibulin-2 [KO:K17307]
107292274  fibulin-2 [KO:K17307]
107287013  FBLN1; fibulin-1 [KO:K17307]
107298504  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
107297852  NID1; nidogen-1 [KO:K06826]
107297062  NID2; nidogen-2 [KO:K06826]
107292554  FN1; fibronectin [KO:K05717]
107294746  SDC1; syndecan-1 isoform X1 [KO:K06257]
107285326  SDC2; syndecan-2 [KO:K16336]
107298624  SDC3; syndecan-3 [KO:K16337]
107287246  SDC4; syndecan-4 [KO:K16338]
107298562  AGRN; agrin [KO:K06254]
107286709  BGN; biglycan [KO:K08118]
107292945  desmocollin-2 isoform X1 [KO:K07601]
107292944  desmocollin-1-like [KO:K07601]
107292802  DSG2; desmoglein-2 [KO:K07597]
107287197  PKP2; plakophilin-2 [KO:K12642]
107303097  JUP; junction plakoglobin [KO:K10056]
107282997  DSP; desmoplakin [KO:K10381]
107283328  VIM; vimentin [KO:K07606]
107288118  DES; desmin [KO:K07610]
107288964  laminin subunit alpha-2 [KO:K05637]
107287708  laminin subunit alpha-2 [KO:K05637]
107285988  LAMA1; laminin subunit alpha-1 [KO:K05637]
107286757  ITGA1; integrin alpha-1 [KO:K06480]
107286758  ITGA2; integrin alpha-2 [KO:K06481]
107302354  ITGA2B; integrin alpha-IIb [KO:K06476]
107282610  ITGA3; integrin alpha-3 [KO:K06482]
107294224  ITGA4; integrin alpha-4 [KO:K06483]
107288179  ITGA5; integrin alpha-5 [KO:K06484]
107291524  ITGA6; integrin alpha-6 [KO:K06485]
107294928  ITGA7; integrin alpha-7 [KO:K06583]
107283308  ITGA8; integrin alpha-8 [KO:K06584]
107283778  integrin alpha-9 [KO:K06585]
114922299  integrin alpha-9-like [KO:K06585]
107288019  ITGA10; integrin alpha-10 [KO:K06586]
107283939  ITGA11; integrin alpha-11 [KO:K06587]
107297042  ITGAV; integrin alpha-V [KO:K06487]
107284025  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
107303035  ITGB3; integrin beta-3 [KO:K06493]
107290217  ITGB4; integrin beta-4 [KO:K06525]
107295717  integrin beta-5-like [KO:K06588]
107294611  ITGB6; integrin beta-6 [KO:K06589]
107288518  ITGB7; integrin beta-7 [KO:K06590]
107282955  ITGB8; integrin beta-8 [KO:K06591]
107283166  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
107287338  TLN1; talin-1 [KO:K06271]
107287903  VCL; vinculin [KO:K05700]
107302624  ACTN3; alpha-actinin-3 [KO:K21073]
107290171  alpha-actinin-2 [KO:K21073]
107286753  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107298106  actin, cytoplasmic 1 [KO:K05692]
107283268  actin, gamma-enteric smooth muscle [KO:K12315]
107289185  DAG1; dystroglycan [KO:K06265]
107282606  SGCA; alpha-sarcoglycan [KO:K12565]
107283647  SGCE; epsilon-sarcoglycan [KO:K27061]
107296282  SGCB; beta-sarcoglycan [KO:K12566]
107293332  SGCD; delta-sarcoglycan [KO:K12563]
107286504  SGCG; gamma-sarcoglycan [KO:K12564]
107288212  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
107295123  SSPN; sarcospan [KO:K22194]
107285573  alpha-1-syntrophin [KO:K24063]
107283546  SNTB2; beta-2-syntrophin isoform X2 [KO:K24064]
107298381  filamin-C [KO:K27393]
107298220  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
107299011  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
107289344  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
107299048  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
107302749  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
107292033  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
107287477  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
107290664  ANK3; LOW QUALITY PROTEIN: ankyrin-3 [KO:K09259]
107298924  SPTAN1; spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
107285653  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
107285498  SPTBN1; spectrin beta chain, non-erythrocytic 1 [KO:K06115]
107288994  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
107290771  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
107284459  cysteine and glycine-rich protein 1 [KO:K09377]
107294559  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
107282532  myosin-1B-like [KO:K24220]
107282590  myosin-1B-like isoform X1 [KO:K24220]
107282542  myosin-1B-like isoform X1 [KO:K24220]
107282501  myosin-3 isoform X1 [KO:K24220]
107285572  LOW QUALITY PROTEIN: myosin-7B [KO:K24220]
107293272  myosin heavy chain, cardiac muscle isoform isoform X3 [KO:K24220]
107293090  myosin-7-like [KO:K17751]
107293091  myosin-7 [KO:K17751]
107283087  myosin-10-like [KO:K10352]
107284008  MYH11; myosin-11 isoform X1 [KO:K10352]
107292597  MYH10; myosin-10 isoform X1 [KO:K10352]
107295783  myosin-10-like isoform X1 [KO:K10352]
107302689  MYH9; myosin-9 isoform X1 [KO:K10352]
107301970  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
107286016  MYL3; myosin light chain 3 [KO:K12749]
107303059  MYL4; myosin light chain 4 [KO:K12750]
107286997  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107292177  MYL5; myosin light chain 5 [KO:K12753]
107286245  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
107288381  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107296378  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107282744  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107289472  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
107282374  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
107289842  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
107294285  MYBPH; myosin-binding protein H [KO:K24494]
107295108  ACTA1; actin, alpha skeletal muscle [KO:K10354]
107299881  actin, alpha cardiac muscle 1 [KO:K12314]
107299889  actin, clone 302-like isoform X1 [KO:K12314]
107287361  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
107287798  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
107282539  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
107299510  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
107297964  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
107297920  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
107302251  troponin T, fast skeletal muscle isoforms [KO:K12046]
107298483  troponin I, cardiac muscle-like [KO:K12044]
107282457  TNNI3; troponin I, cardiac muscle [KO:K12044]
107287797  TNNT2; troponin T, cardiac muscle [KO:K12045]
107283148  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
107287331  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
107285200  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
107282211  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
107290010  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
107289010  MYOT; myotilin isoform X2 [KO:K19875]
107303068  TCAP; telethonin [KO:K19879]
107297628  SYNPO2; synaptopodin-2 [KO:K24066]
107286053  NEB; nebulin [KO:K18267]
107283629  LIM zinc-binding domain-containing Nebulette [KO:K25865]
107299541  MYOZ1; myozenin-1 [KO:K26050]
107289774  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
107300402  MYOZ3; myozenin-3 [KO:K26050]
107302662  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
107289240  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
107297048  PDZ and LIM domain protein 4-like [KO:K23353]
107297290  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
107285372  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
107302442  F-actin-capping protein subunit beta [KO:K10365]
107303323  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
107293214  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
107291549  NRAP; nebulin-related-anchoring protein [KO:K24421]
107288092  MYPN; myopalladin [KO:K22028]
107295478  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
107287206  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
107295468  LIM domain-binding protein 3 [KO:K19867]
107291407  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
107294472  tropomodulin-3-like [KO:K10370]
107295583  TMOD4; tropomodulin-4 [KO:K10370]
107297555  TMOD1; tropomodulin-1 [KO:K10370]
107288772  tropomodulin-2 [KO:K10370]
107289966  ZYX; zyxin [KO:K06273]
107303259  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
107286811  FHL2; four and a half LIM domains protein 2 [KO:K14380]
107283704  FHL3; four and a half LIM domains protein 3 [KO:K24414]
107293131  LMOD2; leiomodin-2 [KO:K22030]
107302645  LMOD3; leiomodin-3 [KO:K22030]
107289272  LMOD1; leiomodin-1 [KO:K22030]
107296610  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
107295217  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
107287954  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
107291324  FMNL2; formin-like protein 2 [KO:K23957]
107303031  FMNL1; formin-like protein 1 [KO:K23957]
107286386  FMNL3; formin-like protein 3 [KO:K23957]
107286274  INF2; inverted formin-2 [KO:K23958]
107290723  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
107294586  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
107299173  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
107295434  protein diaphanous homolog 2-like [KO:K05741]
107284437  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
107288108  FMN2; formin-2 [KO:K02184]
114922916  formin-2-like [KO:K02184]
107293997  MYOM1; myomesin-1 [KO:K24495]
107290285  MYOM2; myomesin-2 [KO:K24495]
107290753  MYOM3; myomesin-3 [KO:K24495]
107285047  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
107285812  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
107292361  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
107286690  ANK2; ankyrin-2 [KO:K09255]
107291634  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
107286447  TRIM54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
107288944  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
107291400  tripartite motif-containing protein 54-like [KO:K10654]
107295685  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
107292613  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
107284051  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
107292138  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
107285997  obscurin [KO:K17531] [EC:2.7.11.1]
107295757  CAPN3; calpain-3 [KO:K08573] [EC:3.4.22.54]
107288484  PLEC; plectin [KO:K10388]
107290207  SYNE3; nesprin-3 [KO:K21761]
107292761  SYNE1; nesprin-1 isoform X1 [KO:K19326]
107285161  SYNE2; nesprin-2 [KO:K19346]
107292457  SUN2; SUN domain-containing protein 2 [KO:K19347]
107291883  SUN1; SUN domain-containing protein 1 [KO:K19347]
107295644  TMEM43; transmembrane protein 43 [KO:K27488]
107284215  EMD; emerin [KO:K12569]
107297430  LBR; delta(14)-sterol reductase isoform X1 [KO:K19532] [EC:1.3.1.70]
107297417  LMNA; lamin [KO:K12641]
107301596  prelamin-A/C-like [KO:K12641]
107283264  LMNB1; lamin-B1 [KO:K07611]
107293605  LMNB2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
pmur04512  ECM-receptor interaction
pmur04814  Motor proteins
KO pathway
ko04820   
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