KEGG   PATHWAY: pmur05168
Entry
pmur05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Protobothrops mucrosquamatus (Taiwan habu)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pmur05168  Herpes simplex virus 1 infection
pmur05168

Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
114922601  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
107282271  tumor necrosis factor receptor superfamily member 14 [KO:K05152]
107296550  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107302543  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107288580  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
107287960  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
107291445  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
114923654  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
107284206  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107290218  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
107299002  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
107297118  RELA; transcription factor p65 [KO:K04735]
107286355  inhibitor of apoptosis protein [KO:K16060]
107285382  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
107297989  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
107286989  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
107288179  ITGA5; integrin alpha-5 [KO:K06484]
107303035  ITGB3; integrin beta-3 [KO:K06493]
107287254  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107291984  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
107292080  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
107282419  IRF3; interferon regulatory factor 3 [KO:K05411]
107299049  cellular tumor antigen p53-like [KO:K04451]
107287994  venom factor [KO:K03990]
107283590  venom factor [KO:K03990]
107298669  C5; complement C5 [KO:K03994]
107296985  CFP; properdin [KO:K15412]
107289574  TLR2; toll-like receptor 2 [KO:K10159]
107288063  toll-like receptor 2 [KO:K10159]
107283615  CD14; monocyte differentiation antigen CD14 [KO:K10159]
107303333  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107292762  uncharacterized protein LOC107292762 [KO:K09447]
107302660  TLR3; toll-like receptor 3 [KO:K05401]
107296141  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
107301311  TIR domain-containing adapter molecule 1-like [KO:K05842]
107284404  IRAK3; interleukin-1 receptor-associated kinase 3 isoform X1 [KO:K04733] [EC:2.7.11.1]
107284218  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
107293338  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107301663  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
107302815  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
107288135  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107287407  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
107283245  IL1B; interleukin-1 beta [KO:K04519]
107282781  IL6; interleukin-6 [KO:K05405]
107296549  tumor necrosis factor-like [KO:K03156]
107292495  interleukin-12 subunit beta-like [KO:K05425]
107296930  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
107285523  interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
107287185  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
107291767  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
107293819  interferon alpha-21-like [KO:K05414]
107298021  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107302715  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
107286959  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107291738  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
107287469  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
107302385  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
107296475  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
107285843  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107285461  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
107293079  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
107283417  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
107286443  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
107297286  translation initiation factor eIF-2B subunit epsilon-like [KO:K03240]
107285479  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
107297389  uncharacterized protein LOC107297389 [KO:K14216] [EC:2.7.7.84]
107284990  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
107284221  HCFC1; host cell factor 1 [KO:K14966]
107294622  HCFC2; host cell factor 2 [KO:K27390]
107292826  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
107297204  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
107301209  POU domain, class 2, transcription factor 3-like [KO:K09364]
107300600  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
107290638  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107290611  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
107296224  suppressor of cytokine signaling 3-like [KO:K04696]
107282474  suppressor of cytokine signaling 3 [KO:K04696]
107290050  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
107294340  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
107285691  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
107289220  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
107290900  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
107298060  uncharacterized protein LOC107298060 [KO:K04693]
107282390  zinc finger protein 239-like [KO:K09228]
107295963  zinc finger protein 268-like [KO:K09228]
107301387  zinc finger protein 84-like [KO:K09228]
107298491  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
107293297  zinc finger protein 345-like [KO:K09228]
107298646  zinc finger protein 436-like [KO:K09228]
107298868  zinc finger protein 501-like [KO:K09228]
107299535  zinc finger protein 157-like [KO:K09228]
107298998  zinc finger protein 260-like [KO:K09228]
107299916  zinc finger protein 282-like [KO:K09228]
107299917  zinc finger protein 786-like [KO:K09228]
107297136  zinc finger protein 208-like [KO:K09228]
107290736  zinc finger protein 420-like [KO:K09228]
107290740  zinc finger protein OZF-like [KO:K09228]
107292841  zinc finger protein 501 [KO:K09228]
107292852  zinc finger protein 93-like [KO:K09228]
107292857  zinc finger protein 501-like [KO:K09228]
107289661  zinc finger protein 239 [KO:K09228]
107294197  zinc finger protein 268-like [KO:K09228]
107300377  zinc finger protein 420-like [KO:K09228]
107300937  zinc finger protein 850-like isoform X1 [KO:K09228]
107288203  zinc finger protein 850-like [KO:K09228]
107294571  zinc finger protein 678 [KO:K09228]
107299816  zinc finger protein 436-like [KO:K09228]
107301092  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
107293058  ZNF777; zinc finger protein 777 [KO:K09228]
107293063  zinc finger protein 398 [KO:K09228]
107298548  zinc finger protein 501 [KO:K09228]
107299242  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
107299244  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
107290503  zinc finger protein 883-like [KO:K09228]
107285447  zinc finger protein 436-like [KO:K09228]
107292849  zinc finger protein 850-like [KO:K09228]
107286928  zinc finger protein 271-like [KO:K09228]
107297148  zinc finger protein OZF-like [KO:K09228]
114923585  LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
114923593  zinc finger protein 429-like [KO:K09228]
107299276  zinc finger protein 850-like [KO:K09228]
107299277  zinc finger protein 91-like [KO:K09228]
107299279  zinc finger protein 665-like [KO:K09228]
107302119  zinc finger protein 84-like [KO:K09228]
107298080  zinc finger protein 2 [KO:K09228]
107300151  zinc finger protein 420-like [KO:K09228]
107300196  zinc finger protein 501-like [KO:K09228]
107300274  zinc finger protein 850-like [KO:K09228]
107300304  zinc finger protein OZF-like [KO:K09228]
107300315  zinc finger protein OZF-like [KO:K09228]
114923679  zinc finger protein 260-like [KO:K09228]
114923680  zinc finger protein 501-like [KO:K09228]
107300345  zinc finger protein 665-like [KO:K09228]
107302165  zinc finger protein 501-like [KO:K09228]
107286185  zinc finger protein 345-like [KO:K09228]
107295361  zinc finger protein 850-like [KO:K09228]
114923383  zinc finger protein 850-like [KO:K09228]
114922610  zinc finger protein 436-like [KO:K09228]
107288182  zinc finger protein 260-like [KO:K09228]
107288214  zinc finger protein 268-like [KO:K09228]
114922789  zinc finger protein 665-like [KO:K09228]
114922983  zinc finger protein 135-like [KO:K09228]
107293062  zinc finger protein 398-like [KO:K09228]
114922151  zinc finger protein 84-like [KO:K09228]
107295078  zinc finger protein 850-like [KO:K09228]
107295357  zinc finger protein 239-like [KO:K09228]
107302220  zinc finger protein 84-like [KO:K09228]
107292015  zinc finger protein 436 [KO:K09228]
107292014  zinc finger protein 2 homolog [KO:K09228]
107292074  zinc finger protein 93-like [KO:K09228]
107296767  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
114923511  zinc finger protein 777-like [KO:K09228]
107297322  zinc finger protein 850 [KO:K09228]
114922148  zinc finger protein 268-like [KO:K09228]
114923387  zinc finger protein 850-like [KO:K09228]
114923388  zinc finger protein 850-like isoform X1 [KO:K09228]
107297479  zinc finger protein 271-like [KO:K09228]
114923602  zinc finger protein OZF-like [KO:K09228]
107299436  zinc finger protein 260-like [KO:K09228]
107299537  zinc finger protein 850-like [KO:K09228]
107293919  zinc finger protein 260 [KO:K09228]
107289452  zinc finger protein 845-like [KO:K09228]
107289455  zinc finger protein 850-like [KO:K09228]
107293296  zinc finger protein OZF-like [KO:K09228]
107299580  zinc finger protein 135-like [KO:K09228]
107299608  zinc finger protein 665-like [KO:K09228]
107299659  zinc finger protein 850-like [KO:K09228]
114922169  zinc finger protein 420-like [KO:K09228]
107298388  zinc finger protein 501-like [KO:K09228]
114922152  zinc finger protein 160-like [KO:K09228]
107298488  zinc finger protein OZF-like [KO:K09228]
114922157  zinc finger protein 883-like [KO:K09228]
107298489  zinc finger protein 501-like [KO:K09228]
107298490  zinc finger protein OZF-like [KO:K09228]
107298492  zinc finger protein OZF-like [KO:K09228]
114923495  zinc finger protein OZF-like [KO:K09228]
107300410  zinc finger protein 260-like [KO:K09228]
107300680  zinc finger protein 850-like [KO:K09228]
107300705  zinc finger protein OZF-like [KO:K09228]
107300713  zinc finger protein 84-like [KO:K09228]
107300797  zinc finger protein 850-like [KO:K09228]
114923231  zinc finger protein 420-like [KO:K09228]
107295895  zinc finger protein 84-like [KO:K09228]
107282522  zinc finger protein 436-like [KO:K09228]
107299876  zinc finger protein OZF-like [KO:K09228]
107299882  zinc finger protein 850-like [KO:K09228]
107297906  zinc finger protein 420-like [KO:K09228]
107297913  zinc finger protein 850-like [KO:K09228]
107297941  zinc finger protein 850-like [KO:K09228]
107287505  zinc finger protein 708-like [KO:K09228]
107287511  zinc finger protein 708-like [KO:K09228]
114922160  zinc finger protein 721-like [KO:K09228]
107289967  zinc finger protein 345-like [KO:K09228]
107294191  zinc finger protein 850-like [KO:K09228]
107294199  zinc finger protein 721-like [KO:K09228]
107296416  zinc finger protein 268-like [KO:K09228]
107296477  zinc finger protein 883-like [KO:K09228]
114922170  zinc finger protein 501-like [KO:K09228]
107298867  zinc finger protein 665-like [KO:K09228]
107298870  zinc finger protein 665 [KO:K09228]
107298935  zinc finger protein 260 [KO:K09228]
107298994  zinc finger protein 420-like [KO:K09228]
107299046  zinc finger protein 850-like [KO:K09228]
107301414  zinc finger protein 84-like [KO:K09228]
107301423  zinc finger protein 501-like [KO:K09228]
107301547  zinc finger protein 501-like [KO:K09228]
107301796  zinc finger protein 726-like [KO:K09228]
107301797  zinc finger protein 501-like [KO:K09228]
107301907  zinc finger protein 665-like [KO:K09228]
107296287  zinc finger protein OZF-like [KO:K09228]
107292843  zinc finger protein CKR1-like [KO:K09228]
107292845  zinc finger protein 239-like [KO:K09228]
107298118  zinc finger protein OZF-like [KO:K09228]
107294027  zinc finger protein 239-like [KO:K09228]
107300478  zinc finger protein 883-like [KO:K09228]
107292012  zinc finger protein OZF-like [KO:K09228]
107301121  zinc finger protein 84-like [KO:K09228]
107298386  zinc finger protein 660-like [KO:K09228]
107300225  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
107300245  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
107299655  zinc finger protein OZF-like [KO:K09228]
107299875  zinc finger protein 84-like [KO:K09228]
107301903  zinc finger protein 239 [KO:K09228]
107301963  zinc finger protein 160-like [KO:K09228]
107302190  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
107289450  zinc finger protein 271-like [KO:K09228]
107289454  zinc finger protein 420-like [KO:K09228]
107294194  zinc finger protein 271-like [KO:K09228]
114923090  zinc finger protein 91-like [KO:K09228]
107284861  zinc finger protein 2 homolog [KO:K09228]
107296768  zinc finger protein 501-like [KO:K09228]
107298645  zinc finger protein 345-like [KO:K09228]
114923572  zinc finger protein 345-like [KO:K09228]
107299236  zinc finger protein 436-like [KO:K09228]
107295172  zinc finger protein 3-like [KO:K09228]
114923177  zinc finger protein OZF-like [KO:K09228]
107295360  zinc finger protein 84-like [KO:K09228]
114923599  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
114923600  zinc finger protein 501-like [KO:K09228]
114923601  zinc finger protein 420-like [KO:K09228]
114923617  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
107299524  gastrula zinc finger protein XlCGF42.1-like [KO:K09228]
114922812  zinc finger protein 420-like [KO:K09228]
114922150  zinc finger protein 708-like [KO:K09228]
107297912  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
107299892  zinc finger protein 814-like [KO:K09228]
114923674  zinc finger protein 665-like [KO:K09228]
114922163  zinc finger protein OZF-like [KO:K09228]
107298549  zinc finger protein 420-like [KO:K09228]
107284417  IFNG; interferon gamma [KO:K04687]
107294497  IFNGR1; interferon gamma receptor 1 [KO:K05132]
107290470  IFNGR2; interferon gamma receptor 2 [KO:K05133]
107291603  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
107300489  protein PML-like [KO:K10054] [EC:2.3.2.-]
107300858  protein PML-like [KO:K10054] [EC:2.3.2.-]
107300869  protein PML [KO:K10054] [EC:2.3.2.-]
107301028  protein PML [KO:K10054] [EC:2.3.2.-]
107300488  protein PML-like [KO:K10054] [EC:2.3.2.-]
107296739  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
107296738  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
107298995  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
107289787  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
107283024  calreticulin [KO:K08057]
107282162  CALR3; calreticulin-3 [KO:K08057]
107285132  CALR; calreticulin [KO:K08057]
107296724  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300169  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299542  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
107298893  HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751]
107295302  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
107300939  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297239  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297243  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297666  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297667  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297668  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107301684  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
107299227  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297241  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299226  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299474  major histocompatibility complex class I-related gene protein [KO:K06751]
107298387  zinc-alpha-2-glycoprotein-like [KO:K06751]
107298892  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107296727  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296788  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297665  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107300336  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300372  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299473  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299476  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299543  major histocompatibility complex class I-related gene protein [KO:K06751]
107296728  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107294635  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296790  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299846  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
114923648  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107300904  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107296734  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107296736  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107296789  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107297240  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297242  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107297244  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107298793  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107299225  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
107299585  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
107301189  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114923271  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114923714  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107294069  B2M; beta-2-microglobulin [KO:K08055]
107301233  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
107296336  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107300204  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300205  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
107298838  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107295588  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107299660  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
107287513  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
107298985  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107299128  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107299911  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
107297179  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300289  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300292  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
107300308  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
107300406  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
107300430  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
107300657  H-2 class II histocompatibility antigen, E-B beta chain-like [KO:K06752]
107300659  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300677  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
107300071  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300754  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
107300856  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
107300882  H-2 class II histocompatibility antigen, E-D alpha chain-like [KO:K06752]
107300883  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
107300886  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107301554  HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752]
107301617  H-2 class II histocompatibility antigen, E-B beta chain-like [KO:K06752]
107301696  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
114923355  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107297079  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107300138  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107300137  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107300325  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107292078  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107299701  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107300685  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107302028  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
107296337  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107298837  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
107298836  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
107290981  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
107285699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107292340  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107284997  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107292269  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107282273  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107283596  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107286152  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107292994  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107302433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107285678  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107296501  TSC1; hamartin [KO:K07206]
107302611  TSC2; tuberin [KO:K07207]
107303314  RHEB; GTP-binding protein Rheb [KO:K07208]
107294607  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107292820  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
107299472  serine/arginine-rich splicing factor 1 [KO:K12890]
107300815  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
107287055  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
107296397  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
107285833  serine/arginine-rich splicing factor 5 [KO:K12893]
107286030  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
107291069  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
107291906  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
107293458  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
107292431  NXF1; nuclear RNA export factor 1 [KO:K14284]
107295823  ALYREF; THO complex subunit 4 [KO:K12881]
107290564  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107284100  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107293774  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107287485  FADD; FAS-associated death domain protein [KO:K02373]
107292278  BID; BH3-interacting domain death agonist [KO:K04726]
107295492  apoptosis regulator BAX-like [KO:K02159]
107282460  apoptosis regulator BAX [KO:K02159]
107282547  apoptosis regulator BAX-like [KO:K02159]
107287068  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107299065  BAD; bcl2-associated agonist of cell death [KO:K02158]
107301245  bcl2-associated agonist of cell death-like [KO:K02158]
107283580  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
107282765  cytochrome c [KO:K08738]
107290550  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
107291376  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107302670  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
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LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
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PLoS One 5:e9560 (2010)
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Reference
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Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
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alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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PMID:12855695
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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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PMID:24262390
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Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Virol J 13:38 (2016)
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
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Viruses 1:737-59 (2009)
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The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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Reference
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Reference
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Related
pathway
pmur03040  Spliceosome
pmur03050  Proteasome
pmur04115  p53 signaling pathway
pmur04210  Apoptosis
pmur04620  Toll-like receptor signaling pathway
pmur04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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