KEGG   PATHWAY: pteh04936
Entry
pteh04936                   Pathway                                
Name
Alcoholic liver disease - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
pteh04936  Alcoholic liver disease
pteh04936

Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111547714  C1QA; complement C1q subcomponent subunit A [KO:K03986]
111547712  C1QB; complement C1q subcomponent subunit B [KO:K03987]
111547713  C1QC; complement C1q subcomponent subunit C [KO:K03988]
111531048  complement C4-B [KO:K03989]
111522637  C3; complement C3 [KO:K03990]
111526620  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
111550334  C5; complement C5 [KO:K03994]
111556087  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
111553292  LBP; lipopolysaccharide-binding protein [KO:K05399]
111528037  CD14; monocyte differentiation antigen CD14 [KO:K04391]
111520969  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
111550322  TLR4; toll-like receptor 4 [KO:K10160]
111540313  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
111523175  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
111520209  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111531307  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
111521878  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111548993  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111523666  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111538092  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111538794  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111544093  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111524454  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111523940  TNF; tumor necrosis factor [KO:K03156]
111528224  IL1B; interleukin-1 beta [KO:K04519]
111545050  IL6; interleukin-6 isoform X1 [KO:K05405]
111550126  IL12A; interleukin-12 subunit alpha [KO:K05406]
111547191  IL12B; interleukin-12 subunit beta [KO:K05425]
111531283  CXCL8; interleukin-8 [KO:K10030]
111521961  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
111538162  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111522719  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111551230  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111539247  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
111519959  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111537187  interferon alpha-14 [KO:K05414]
111537188  interferon alpha-6 [KO:K05414]
111537189  interferon alpha-2 [KO:K05414]
111537190  interferon alpha-8 [KO:K05414]
111537191  interferon alpha-1/13 [KO:K05414]
111526141  interferon alpha-10 [KO:K05414]
111526147  IFNB1; interferon beta [KO:K05415]
111543200  IL17A; interleukin-17A [KO:K05489]
111526410  IL17RA; interleukin-17 receptor A [KO:K05164]
111546940  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
111528185  growth-regulated alpha protein-like isoform X2 [KO:K05505]
111531279  growth-regulated protein homolog gamma-like [KO:K05505]
111531286  CXCL1; growth-regulated alpha protein [KO:K05505]
111524574  growth-regulated alpha protein-like [KO:K05505]
111539343  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111551313  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111522332  FADD; FAS-associated death domain protein [KO:K02373]
111555942  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111541333  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
111547169  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111551382  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
111548479  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111548565  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
111536582  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
111526176  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
111527639  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
111537683  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111538803  SCD; acyl-CoA desaturase isoform X1 [KO:K00507] [EC:1.14.19.1]
111549395  SCD5; stearoyl-CoA desaturase 5 isoform X1 [KO:K00507] [EC:1.14.19.1]
111553270  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
111532065  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
111553515  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
111537942  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
111523239  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
111545065  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
111544373  ADIPOQ; adiponectin [KO:K07296]
111520283  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
111522803  ADIPOR1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
111537867  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
111523274  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
111545491  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
111537590  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
111527236  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
111542041  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
111551530  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X6 [KO:K07200]
111546071  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
111540508  FOXO1; forkhead box protein O1 [KO:K07201]
111538546  FOXO3; forkhead box protein O3 [KO:K09408]
111549861  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
111548903  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
111522235  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
111521283  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2 [KO:K09479] [EC:1.3.8.9]
111540788  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
111539103  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
111528201  FABP1; fatty acid-binding protein, liver [KO:K08750]
113223322  alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
111534960  all-trans-retinol dehydrogenase [NAD(+)] ADH1B-like [KO:K13951] [EC:1.1.1.1]
113223323  all-trans-retinol dehydrogenase [NAD(+)] ADH1B-like [KO:K13951] [EC:1.1.1.1]
113223324  all-trans-retinol dehydrogenase [NAD(+)] ADH1B [KO:K13951] [EC:1.1.1.1]
111525512  alcohol dehydrogenase 1A-like [KO:K13951] [EC:1.1.1.1]
111547956  ADH7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
111547998  alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
111525498  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X1 [KO:K13980] [EC:1.1.1.1]
111525499  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
111525514  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
111528834  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
111537053  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
111534992  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
111529996  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
111539280  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
111522057  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
111538813  ACACB; LOW QUALITY PROTEIN: acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111552525  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
111549110  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
111519958  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
111540684  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111543871  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111555526  CTNNB1; catenin beta-1 [KO:K02105]
111529175  TCF7; transcription factor 7 isoform X1 [KO:K02620]
111551134  TCF7L1; transcription factor 7-like 1 [KO:K04490]
111538904  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
111547880  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
111522272  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111525521  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111523480  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111522663  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111530867  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111535725  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111554538  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111528301  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111542478  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111542972  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111542973  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111532954  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111549140  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111525786  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
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Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
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Annu Rev Nutr 32:343-68 (2012)
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Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
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Reference
PMID:24385684
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Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
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World J Gastroenterol 16:1321-9 (2010)
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Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
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Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
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J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
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Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
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IUBMB Life 60:790-7 (2008)
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Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
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Int J Biol Sci 16:3174-3183 (2020)
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Reference
PMID:19032584
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Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
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Alcohol Clin Exp Res 33:191-205 (2009)
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Reference
PMID:34071962
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Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
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Int J Mol Sci 22:5717 (2021)
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Reference
PMID:24297186
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Combs TP, Marliss EB
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Adiponectin signaling in the liver.
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Rev Endocr Metab Disord 15:137-47 (2014)
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Reference
PMID:25548474
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Ceni E, Mello T, Galli A
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Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
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World J Gastroenterol 20:17756-72 (2014)
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Reference
PMID:31159489
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Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
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Int J Mol Sci 20:E2712 (2019)
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Reference
PMID:31214376
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Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
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Liver Res 2:161-172 (2018)
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Reference
PMID:30658725
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You M, Arteel GE
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Effect of ethanol on lipid metabolism.
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J Hepatol 70:237-248 (2019)
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Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
pteh00061  Fatty acid biosynthesis
pteh00071  Fatty acid degradation
pteh01040  Biosynthesis of unsaturated fatty acids
pteh03040  Spliceosome
pteh04010  MAPK signaling pathway
pteh04064  NF-kappa B signaling pathway
pteh04152  AMPK signaling pathway
pteh04210  Apoptosis
pteh04310  Wnt signaling pathway
pteh04610  Complement and coagulation cascades
pteh04620  Toll-like receptor signaling pathway
pteh04657  IL-17 signaling pathway
pteh04668  TNF signaling pathway
pteh04920  Adipocytokine signaling pathway
pteh05034  Alcoholism
pteh05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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