KEGG   PATHWAY: pteh04010
Entry
pteh04010                   Pathway                                
Name
MAPK signaling pathway - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pteh04010  MAPK signaling pathway
pteh04010

Other DBs
GO: 0000165
Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111523866  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
111553106  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
111520328  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111524370  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111536962  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111537578  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111524152  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
111549100  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
111550963  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111552459  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3 [KO:K04858]
111555399  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
111524372  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
111520325  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
111537479  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111549941  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111542053  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
111546115  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
111542584  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111549051  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
111524205  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
111542585  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111542586  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111530481  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111530492  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
111530480  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
111523821  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111543418  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
111540404  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111542503  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111524197  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111530493  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111523703  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
111541090  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111545684  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111537850  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111547968  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111550575  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
111536216  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
111527206  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111544445  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
111554594  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111522280  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
111545404  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
111554039  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
111553506  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111520244  NF1; neurofibromin [KO:K08052]
111544466  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
111526428  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
111556041  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
111528626  RAP1B; ras-related protein Rap-1b [KO:K07836]
111532119  ras-related protein Rap-1b [KO:K07836]
111547933  EGF; pro-epidermal growth factor [KO:K04357]
111550529  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
111524571  EREG; proepiregulin [KO:K09784]
111524578  AREG; amphiregulin [KO:K09782]
111523283  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111546245  FGF2; fibroblast growth factor 2 [KO:K18497]
111528737  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
111534218  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111552814  FGF7; fibroblast growth factor 7 [KO:K04358]
111522276  FGF3; fibroblast growth factor 3 [KO:K04358]
111522486  FGF4; fibroblast growth factor 4 [KO:K04358]
111535838  FGF6; fibroblast growth factor 6 [KO:K04358]
111536051  FGF16; fibroblast growth factor 16 [KO:K04358]
111525307  FGF9; fibroblast growth factor 9 [KO:K04358]
111547150  FGF18; fibroblast growth factor 18 [KO:K04358]
111547417  FGF20; fibroblast growth factor 20 [KO:K04358]
111538699  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
111549401  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
111522468  FGF19; fibroblast growth factor 19 [KO:K22603]
111519986  FGF21; fibroblast growth factor 21 [KO:K22429]
111535828  FGF23; fibroblast growth factor 23 [KO:K22428]
111549636  NGF; beta-nerve growth factor [KO:K02582]
111554690  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
111555967  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
113223046  neurotrophin-4 [KO:K12457]
111520090  neurotrophin-4 [KO:K12457]
111520623  INS; insulin isoform X1 [KO:K04526]
111523785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111520622  IGF2; insulin-like growth factor II [KO:K13769]
111523727  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111549133  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111553384  PDGFC; platelet-derived growth factor C [KO:K05450]
111540080  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111556006  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111538065  KITLG; kit ligand isoform X1 [KO:K05461]
113219545  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
111520142  fms-related tyrosine kinase 3 ligand [KO:K05454]
111543089  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111522374  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
111520971  PGF; placenta growth factor isoform X1 [KO:K16859]
111531650  VEGFD; vascular endothelial growth factor D [KO:K05449]
111554086  VEGFC; vascular endothelial growth factor C [KO:K05449]
111552446  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
111551202  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
111547381  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
111548219  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
111542672  EFNA5; ephrin-A5 [KO:K05462]
111543743  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
111543744  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
111543746  EFNA1; ephrin-A1 [KO:K05462]
111526782  EFNA2; ephrin-A2 [KO:K05462]
111545603  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
111530846  NRTN; neurturin [KO:K25414]
111548823  ARTN; artemin isoform X1 [KO:K25415]
111522639  PSPN; persephin [KO:K25416]
111555709  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111537465  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111541863  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111548039  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
111544121  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111550787  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111539069  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111521629  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111537554  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111543817  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111554169  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111522649  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
111548389  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111520430  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111552670  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111552684  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111520450  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
111540451  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
111540453  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111527329  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111526494  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111553422  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111537223  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
111527303  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
111531334  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111542428  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111545353  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111549528  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111540622  KRAS; GTPase KRas isoform X1 [KO:K07827]
111549619  NRAS; GTPase NRas [KO:K07828]
113224120  ras-related protein R-Ras [KO:K07829]
113224122  ras-related protein R-Ras [KO:K07829]
113224127  ras-related protein R-Ras [KO:K07829]
111519962  ras-related protein R-Ras [KO:K07829]
111555029  RRAS2; ras-related protein R-Ras2 [KO:K07830]
111523367  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
111536410  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111521522  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111546904  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111548354  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111521954  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111547966  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111520663  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111548788  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
111550272  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
111531635  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111547648  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111536468  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
111548140  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111548991  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111535736  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
111522698  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
111550563  MYC; myc proto-oncogene protein [KO:K04377]
111543068  SRF; serum response factor [KO:K04378]
111521118  FOS; proto-oncogene c-Fos [KO:K04379]
111529278  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
111534792  LOW QUALITY PROTEIN: stathmin-like [KO:K04381]
111547661  STMN1; stathmin [KO:K04381]
111534477  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113224231  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
111520161  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
111531132  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
111531141  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
111531158  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
111536920  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
111523940  TNF; tumor necrosis factor [KO:K03156]
111528223  IL1A; interleukin-1 alpha [KO:K04383]
111528224  IL1B; interleukin-1 beta [KO:K04519]
111554142  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
111537117  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
111555026  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
111555942  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111542169  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
111544285  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
111536462  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111526524  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
111539343  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111551313  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111528037  CD14; monocyte differentiation antigen CD14 [KO:K04391]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111549042  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111527658  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111547718  CDC42; cell division control protein 42 homolog [KO:K04393]
111541333  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
111551382  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
111548479  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111553030  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111542921  death domain-associated protein 6 isoform X1 [KO:K02308]
116418805  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
111523175  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
111531307  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
111520209  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111521878  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111541101  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111528537  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111520681  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111548993  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111523666  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111523816  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
111545352  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111542172  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111554012  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
111540806  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
111544329  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111553311  STK4; serine/threonine-protein kinase 4 [KO:K04411]
113224962  STK3; serine/threonine-protein kinase 3 [KO:K04412]
111520894  serine/threonine-protein kinase 3 [KO:K04412]
111522310  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
111546640  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
111541624  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111522421  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
111551574  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111527597  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
111520286  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
111554068  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
111545260  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
111541924  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
111523200  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111522164  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111547629  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
111525521  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111538092  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111550306  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
111520764  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
111537560  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
111525702  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
111523480  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111522663  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111528301  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111542478  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111544921  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
111549109  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
111524084  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
111530661  CRKL; crk-like protein [KO:K04438]
111530638  CRK; adapter molecule crk isoform X1 [KO:K04438]
111540828  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
111521236  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
111530867  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111535725  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111554538  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111542972  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111542973  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111532954  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111549140  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111537063  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
111522809  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111555437  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
111538215  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
111522296  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
111548062  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
111551042  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111541379  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111523160  JUN; transcription factor AP-1 [KO:K04448]
113219582  JUND; transcription factor jun-D [KO:K04449]
111554263  transcription factor jun-D [KO:K04449]
111542753  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111527100  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111541810  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
111555948  MAX; protein max isoform X1 [KO:K04453]
111544469  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111547067  HSPB1; heat shock protein beta-1 [KO:K04455]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111555567  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
111552345  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
111555061  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
111522829  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
111547221  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111528768  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111542234  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111520631  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111552028  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111545755  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111538888  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111549631  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111534018  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
111537105  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111525842  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111519970  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111550404  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
113222861  heat shock 70 kDa protein 1 [KO:K03283]
111523910  heat shock 70 kDa protein 1 [KO:K03283]
111525033  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
111523908  heat shock 70 kDa protein 1 [KO:K03283]
111523909  heat shock 70 kDa protein 1-like [KO:K03283]
111540268  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111543501  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
111548340  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
111528146  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
111541979  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111525786  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
111538794  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111544093  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111520786  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111538840  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111520082  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pteh04070  Phosphatidylinositol signaling system
pteh04110  Cell cycle
pteh04115  p53 signaling pathway
pteh04210  Apoptosis
pteh04310  Wnt signaling pathway
pteh04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system