Entry Name Parathyroid hormone synthesis, secretion and action - Panthera uncia (snow leopard)
Description Parathyroid hormone (PTH) is a key regulator of calcium and phosphorus homeostasis. The principal regulators of PTH secretion are extracellular ionized calcium (Ca2+) and 1,25-dihydroxyvitamin D (1,25(OH)2D3). Under conditions of dietary Ca restriction, a decrement in serum Ca concentration induces release of PTH from the parathyroid gland. PTH acts on bone and kidney to stimulate bone turnover, increase the circulating levels of 1,25(OH)2D3 and calcium and inhibit the reabsorption of phosphate from the glomerular filtrate. This hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R). PTH1R primarily activates two sub-types of heterotrimeric Gproteins: Gs and Gq , which in turn regulate the activity of adenylyl cyclases and phospholipase C (PLC) that control the flow of cAMP/PKA and IP/PKC signaling cascades, respectively.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map puc04928 Parathyroid hormone synthesis, secretion and action
Ortholog table Organism Panthera uncia (snow leopard) [GN:
puc ]
Gene 125921008 LOW QUALITY PROTEIN: extracellular calcium-sensing receptor [KO:K04612 ]
125929389 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
125929845 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
125912291 guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
125925154 guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
125929585 inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
125920161 inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
125938578 LOW QUALITY PROTEIN: chorion-specific transcription factor GCMa [KO:K21598 ]
125919963 trans-acting T-cell-specific transcription factor GATA-3 isoform X1 [KO:K17895 ]
125929303 parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1 [KO:K04585 ]
125930263 transient receptor potential cation channel subfamily V member 5 [KO:K04974 ]
125936451 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
125932378 nascent polypeptide-associated complex subunit alpha-like [KO:K03626 ]
125918316 nascent polypeptide-associated complex subunit alpha, muscle-specific form-like [KO:K03626 ]
125933514 nascent polypeptide-associated complex subunit alpha-like [KO:K03626 ]
125911260 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
125911819 cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
125930188 cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
125925743 cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
125934155 cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
125919439 cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
125928859 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
125930855 cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
125938414 cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
125925654 LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Khundmiri SJ, Murray RD, Lederer E
Title PTH and Vitamin D.
Journal Reference Authors Bastepe M, Turan S, He Q
Title Heterotrimeric G proteins in the control of parathyroid hormone actions.
Journal Reference Authors Vilardaga JP, Romero G, Friedman PA, Gardella TJ
Title Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.
Journal Reference Authors Naveh-Many T, Silver J
Title Transcription factors that determine parathyroid development power PTH expression.
Journal Reference Authors Han SI, Tsunekage Y, Kataoka K
Title Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Journal Reference Authors Ferre S, Hoenderop JG, Bindels RJ
Title Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis.
Journal Reference Authors Komaba H, Fukagawa M
Title FGF23-parathyroid interaction: implications in chronic kidney disease.
Journal Reference Authors Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Title Primary hyperparathyroidism.
Journal Reference Authors de Groot T, Kovalevskaya NV, Verkaart S, Schilderink N, Felici M, van der Hagen EA, Bindels RJ, Vuister GW, Hoenderop JG
Title Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone.
Journal Reference Authors Hernando N, Wagner C, Biber J, Murer H
Title Kidney kinase network regulates renal ion cotransport.
Journal Reference Authors Wang B, Means CK, Yang Y, Mamonova T, Bisello A, Altschuler DL, Scott JD, Friedman PA
Title Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport.
Journal Reference Authors Crenshaw TD, Rortvedt LA, Hassen Z
Title Triennial Growth Symposium: a novel pathway for vitamin D-mediated phosphate homeostasis: implications for skeleton growth and mineralization.
Journal Reference Authors Zierold C, Mings JA, DeLuca HF
Title Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability.
Journal Reference Authors Kramer I, Keller H, Leupin O, Kneissel M
Title Does osteocytic SOST suppression mediate PTH bone anabolism?
Journal Reference Authors Leupin O, Kramer I, Collette NM, Loots GG, Natt F, Kneissel M, Keller H
Title Control of the SOST bone enhancer by PTH using MEF2 transcription factors.
Journal Reference Authors Meir T, Durlacher K, Pan Z, Amir G, Richards WG, Silver J, Naveh-Many T
Title Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription.
Journal Reference Authors Pellicelli M, Hariri H, Miller JA, St-Arnaud R
Title Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator.
Journal Reference Authors Fu Q, Jilka RL, Manolagas SC, O'Brien CA
Title Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.
Journal Reference Authors O'Brien CA
Title Control of RANKL gene expression.
Journal Reference Authors Jilka RL
Title Molecular and cellular mechanisms of the anabolic effect of intermittent PTH.
Journal Reference Authors Pearman AT, Chou WY, Bergman KD, Pulumati MR, Partridge NC
Title Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE.
Journal Reference Authors Boumah CE, Selvamurugan N, Partridge NC
Title Transcription in the osteoblast: regulatory mechanisms utilized by parathyroid hormone and transforming growth factor-beta.
Journal Reference Authors Hess J, Porte D, Munz C, Angel P
Title AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
Journal Reference Authors Singh AT, Gilchrist A, Voyno-Yasenetskaya T, Radeff-Huang JM, Stern PH
Title G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells.
Journal Reference Authors Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM
Title Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
Journal Reference Authors Sneddon WB, Yang Y, Ba J, Harinstein LM, Friedman PA
Title Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.
Journal Reference Authors Agoro R, Ni P, Noonan ML, White KE
Title Osteocytic FGF23 and Its Kidney Function.
Journal Reference Authors Erben RG, Andrukhova O
Title FGF23-Klotho signaling axis in the kidney.
Journal Reference Authors Murillo-de-Ozores AR, Rodriguez-Gama A, Carbajal-Contreras H, Gamba G, Castaneda-Bueno M
Title WNK4 kinase: from structure to physiology.
Journal Related puc04961 Endocrine and other factor-regulated calcium reabsorption
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