KEGG   PATHWAY: sgh04270
Entry
sgh04270                    Pathway                                
Name
Vascular smooth muscle contraction - Sinocyclocheilus grahami (golden-line barbel)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
sgh04270  Vascular smooth muscle contraction
sgh04270

Other DBs
GO: 0014829
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107560518  alpha-1A adrenergic receptor-like [KO:K04135]
107552152  alpha-1A adrenergic receptor-like [KO:K04135]
107553034  alpha-1A adrenergic receptor-like [KO:K04135]
107561387  alpha-1A adrenergic receptor-like [KO:K04135]
107557042  alpha-1A adrenergic receptor-like [KO:K04136]
107586059  alpha-1A adrenergic receptor-like [KO:K04136]
107590113  alpha-1A adrenergic receptor-like [KO:K04136]
107552750  alpha-1D adrenergic receptor-like [KO:K04137]
107567044  alpha-1D adrenergic receptor-like [KO:K04137]
107552950  angiotensinogen-like [KO:K09821]
107601848  angiotensinogen-like [KO:K09821]
107588039  type-1 angiotensin II receptor A-like [KO:K04166]
107584999  type-1B angiotensin II receptor-like [KO:K04166]
107550594  type-1 angiotensin II receptor-like [KO:K04166]
107557561  type-1 angiotensin II receptor A-like [KO:K04166]
107576085  type-1 angiotensin II receptor A-like [KO:K04166]
107551767  endothelin-1-like [KO:K16366]
107559691  endothelin-1-like [KO:K16366]
107569866  endothelin-2-like [KO:K16367]
107595907  endothelin-2-like [KO:K16367]
107597135  endothelin-2-like [KO:K16367]
107558944  endothelin-2-like [KO:K16367]
107587847  long-sarafotoxin-like [KO:K16367]
107553437  endothelin-2-like [KO:K16367]
107594747  endothelin-3-like [KO:K05227]
107551532  endothelin-3-like [KO:K05227]
107550331  endothelin-3-like [KO:K05227]
107551313  endothelin-3-like [KO:K05227]
107550651  endothelin-1 receptor-like isoform X1 [KO:K04197]
107598731  endothelin-1 receptor-like [KO:K04197]
107565324  endothelin-1 receptor-like [KO:K04197]
107570196  endothelin-1 receptor-like [KO:K04197]
107581163  vasotocin-neurophysin VT 1-like [KO:K05242]
107568101  vasotocin-neurophysin VT 1-like [KO:K05242]
107549611  arg8-vasotocin receptor-like [KO:K04226]
107574231  arg8-vasotocin receptor-like [KO:K04226]
107592260  arg8-vasotocin receptor [KO:K04226]
107581276  arg8-vasotocin receptor-like [KO:K04226]
107596000  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107593323  guanine nucleotide-binding protein subunit alpha-11 [KO:K04634]
107586405  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04634]
107600584  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
107586443  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
107600186  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
107558284  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
107564125  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107582608  uncharacterized protein LOC107582608 [KO:K01047] [EC:3.1.1.4]
107592754  uncharacterized protein LOC107592754 [KO:K01047] [EC:3.1.1.4]
107564523  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
107551354  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
107557937  group XIIA secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
107564700  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107588994  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107568924  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107554411  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
107554412  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
107550943  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107550944  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
107583642  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
107591457  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107599091  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
107583702  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
107591493  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107594671  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
107563421  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107553138  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
107553151  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
107553182  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
107563437  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107563438  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107599554  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
107589895  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
107559554  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
107602675  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
107589535  LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1-like [KO:K04936]
107597763  calcium-activated potassium channel subunit alpha-1-like [KO:K04936]
107595209  calcium-activated potassium channel subunit alpha-1-like [KO:K04936]
107582501  calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
107579315  calcium-activated potassium channel subunit beta-2-like [KO:K04938]
107600278  calcium-activated potassium channel subunit beta-2-like isoform X1 [KO:K04938]
107568625  calcium-activated potassium channel subunit beta-2-like isoform X1 [KO:K04938]
107599858  calcium-activated potassium channel subunit beta-3-like [KO:K04939]
107590584  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
107589041  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
107581799  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
107549565  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
107594982  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
107582429  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
107548248  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
107549945  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
107550115  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
107550462  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857]
107572552  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
107591792  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
107581490  calmodulin [KO:K02183]
107597846  calmodulin-like [KO:K02183]
107548236  calmodulin [KO:K02183]
107582745  calmodulin [KO:K02183]
107582783  calmodulin [KO:K02183]
107593483  calmodulin-like isoform X1 [KO:K02183]
107549625  calmodulin-like protein 4 isoform X1 [KO:K02183]
107559413  calmodulin [KO:K02183]
107561747  calmodulin-A isoform X1 [KO:K02183]
107550044  calmodulin [KO:K02183]
107590878  calmodulin [KO:K02183]
107586481  calmodulin [KO:K02183]
107563455  calmodulin-like protein 4 [KO:K02183]
107553107  calmodulin-like protein 4 [KO:K02183]
107590004  calm2; calmodulin [KO:K02183]
107555454  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107555236  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107549024  probable WRKY transcription factor 19 [KO:K00907] [EC:2.7.11.18]
107555775  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107598691  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107602975  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
107583040  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107565501  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
107562868  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
107572770  mucin-5AC-like [KO:K00907] [EC:2.7.11.18]
107591027  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107564009  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107559533  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107570608  myosin light polypeptide 6 isoform X1 [KO:K12751]
107582695  myosin light polypeptide 6-like [KO:K12751]
107585121  myosin light polypeptide 6-like isoform X1 [KO:K12751]
107586536  myosin light polypeptide 6 isoform X1 [KO:K12751]
107569439  myosin regulatory light polypeptide 9 [KO:K12755]
107554878  myosin regulatory light polypeptide 9-like [KO:K12755]
107582309  myosin regulatory light polypeptide 9-like [KO:K12755]
107551888  LOW QUALITY PROTEIN: myosin-10-like [KO:K10352]
107551906  myosin-11-like isoform X1 [KO:K10352]
107563767  myh9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
107572814  myosin-9-like [KO:K10352]
107581318  myosin-9-like [KO:K10352]
107581334  myosin-11-like isoform X1 [KO:K10352]
107581403  myosin-10-like [KO:K10352]
107551920  myosin-9-like [KO:K10352]
107552868  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
107552879  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
107594127  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107557900  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107557901  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107560167  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107569311  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
107583283  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107564330  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
107564333  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107581741  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107582692  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107585177  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107553933  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107583890  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
107549213  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
107555587  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
107556610  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
107569462  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107586338  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
107590404  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
107601253  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107564527  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107590741  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
107549470  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
107598407  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
107558893  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
107582675  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
107600299  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
107550054  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
107582770  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
107586499  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
107590020  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
107548619  protein kinase C eta type-like [KO:K18051] [EC:2.7.11.13]
107563690  protein kinase C eta type-like [KO:K18051] [EC:2.7.11.13]
107589067  protein kinase C eta type-like [KO:K18051] [EC:2.7.11.13]
107555829  protein kinase C theta type-like isoform X1 [KO:K18052] [EC:2.7.11.13]
107597022  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
107592338  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107595004  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
107560707  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
107594271  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107564278  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107571214  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107555780  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
107583767  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
107596971  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107575785  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107596877  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107552672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
107586388  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107574272  caldesmon-like [KO:K12327]
107583995  non-muscle caldesmon-like [KO:K12327]
107595253  non-muscle caldesmon-like [KO:K12327]
107579938  non-muscle caldesmon-like [KO:K12327]
107590809  non-muscle caldesmon-like [KO:K12327]
107549254  non-muscle caldesmon-like [KO:K12327]
107584142  actin, aortic smooth muscle [KO:K12313]
107548483  protein phosphatase 1 regulatory subunit 14A-like [KO:K12328]
107597604  protein phosphatase 1 regulatory subunit 14A-like isoform X1 [KO:K12328]
107596215  protein phosphatase 1 regulatory subunit 14A-like [KO:K12328]
107586311  protein phosphatase 1 regulatory subunit 14A-like [KO:K12328]
107563994  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
107582864  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
107551850  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
107583611  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107563423  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107567955  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B isoform X1 [KO:K06269] [EC:3.1.3.16]
107583066  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
107556769  serine/threonine-protein phosphatase alpha-2 isoform-like isoform X1 [KO:K06269] [EC:3.1.3.16]
107560300  ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
107561184  protein phosphatase 1 regulatory subunit 12A-like [KO:K06270]
107591124  protein phosphatase 1 regulatory subunit 12A-like [KO:K06270]
107551438  protein phosphatase 1 regulatory subunit 12A-like [KO:K06270]
107601321  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
107569470  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
107586341  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
107592501  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107581709  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107590387  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
107601276  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
107554062  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
107584085  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
107600769  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107556420  rho guanine nucleotide exchange factor 12-like [KO:K07532]
107586229  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107601722  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107595767  rho guanine nucleotide exchange factor 1-like isoform X1 [KO:K12330]
107593668  arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
107564166  rho guanine nucleotide exchange factor 11-like [KO:K12331]
107579050  transforming protein RhoA-like [KO:K04513]
107549297  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107562777  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107569805  rho-related GTP-binding protein RhoA-D [KO:K04513]
107599000  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107603137  rho-related GTP-binding protein RhoA-A [KO:K04513]
107558917  rho-related GTP-binding protein RhoA-C [KO:K04513]
107571578  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107556503  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107591763  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107591788  rho-related GTP-binding protein RhoA-B [KO:K04513]
107593752  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
107567877  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.39]
107602474  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.39]
107555625  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
107588686  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.39]
107585483  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
107600048  adenosine receptor A2b-like [KO:K04266]
107584529  adenosine receptor A2b-like [KO:K04266]
107600912  adenosine receptor A2b-like [KO:K04266]
107595487  adenosine receptor A2b-like [KO:K04267]
107587731  adenosine receptor A2b-like [KO:K04267]
107567267  prostacyclin receptor-like [KO:K04263]
107593372  calcitonin-1-like isoform X1 [KO:K12332]
107573396  calcitonin gene-related peptide-like isoform X1 [KO:K12332]
107586036  calcitonin gene-related peptide-like isoform X1 [KO:K12332]
107584747  ADM-like [KO:K12333]
107552986  ADM-like [KO:K12333]
107592207  ADM2-like [KO:K25343]
107580886  ADM2-like [KO:K25343]
107564903  ADM2-like [KO:K25343]
107602163  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
107584849  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
107565313  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
107584159  calcitonin gene-related peptide type 1 receptor [KO:K04577]
107555409  calcitonin gene-related peptide type 1 receptor-like isoform X1 [KO:K04577]
107570190  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
107590449  receptor activity-modifying protein 1-like [KO:K08448]
107601292  receptor activity-modifying protein 1-like [KO:K08448]
107573297  receptor activity-modifying protein 3-like isoform X1 [KO:K08449]
107572625  receptor activity-modifying protein 3-like isoform X1 [KO:K08449]
107599701  uncharacterized protein LOC107599701 isoform X1 [KO:K08449]
107596786  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
107554191  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
107568325  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107568330  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107559745  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107563079  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107581454  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107595616  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107551198  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107584338  adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107598935  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
107593287  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
107572836  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
107555914  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
107596066  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
107568450  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107601336  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107594095  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107571464  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
107551487  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
107554606  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
107569488  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107549698  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107594777  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107603098  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
107592799  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
107557810  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107566051  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
107553626  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
107601541  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107566672  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
107562862  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107600310  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107602709  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
107560415  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107592581  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107599301  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107573599  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107594309  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
107595801  natriuretic peptides A-like [KO:K12334]
107602452  natriuretic peptides A-like [KO:K12334]
107602446  brain natriuretic peptide-like [KO:K12335]
107595789  brain natriuretic peptide-like [KO:K12335]
107598010  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
107595800  C-type natriuretic peptide 3-like [KO:K12336]
107602453  C-type natriuretic peptide 3-like [KO:K12336]
107574759  C-type natriuretic peptide 4-like [KO:K12336]
107570460  C-type natriuretic peptide 4-like [KO:K12336]
107595992  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
107559735  atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
107563522  atrial natriuretic peptide receptor 2-like isoform X1 [KO:K12324] [EC:4.6.1.2]
107557353  prkg1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
107586071  cGMP-dependent protein kinase 1-like [KO:K07376] [EC:2.7.11.12]
107584697  protein MRVI1-like [KO:K12337]
107552971  protein MRVI1-like [KO:K12337]
107572203  guanylate cyclase soluble subunit alpha-3-like isoform X1 [KO:K12318] [EC:4.6.1.2]
107598251  guanylate cyclase soluble subunit alpha-3-like [KO:K12318] [EC:4.6.1.2]
107560840  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
107566890  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
107581489  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
107598282  gucy1b3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
107598617  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
sgh00590  Arachidonic acid metabolism
sgh04020  Calcium signaling pathway
KO pathway
ko04270   
LinkDB

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