KEGG   PATHWAY: snh04520
Entry
snh04520                    Pathway                                
Name
Adherens junction - Salvelinus namaycush (lake trout)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
snh04520  Adherens junction
snh04520

Other DBs
GO: 0005912
Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120041559  nectin-1-like [KO:K06081]
120042604  nectin1a; nectin cell adhesion molecule 1a [KO:K06081]
120030757  poliovirus receptor-like [KO:K06531]
120048493  si:ch73-22o12.1; poliovirus receptor isoform X1 [KO:K06531]
120022450  poliovirus receptor-like isoform X1 [KO:K06531]
120026916  poliovirus receptor-like isoform X1 [KO:K06531]
120018206  nectin-3-like protein [KO:K06592]
120043703  nectin-3-like protein [KO:K06592]
120028880  nectin-3-like protein [KO:K06592]
120057499  nectin-3-like protein [KO:K06592]
120020638  nectin-4-like [KO:K06593]
120030242  nectin-4-like [KO:K06593]
120049675  nectin-4-like [KO:K06593]
120056063  nectin-4-like isoform X1 [KO:K06593]
120020398  partitioning defective 3 homolog isoform X1 [KO:K04237]
120028005  partitioning defective 3 homolog isoform X1 [KO:K04237]
120055864  partitioning defective 3 homolog [KO:K04237]
120026609  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
120064659  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
120059156  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120060656  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120055100  farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
120022191  cell division control protein 42 homolog [KO:K04393]
120048613  cell division control protein 42 homolog [KO:K04393]
120048723  cell division control protein 42 homolog [KO:K04393]
120027141  cell division control protein 42 homolog [KO:K04393]
120065151  cell division control protein 42 homolog [KO:K04393]
120059210  cell division control protein 42 homolog [KO:K04393]
120060785  cell division control protein 42 homolog [KO:K04393]
120061169  cell division control protein 42 homolog isoform X1 [KO:K04393]
120030096  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120040646  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
120040650  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
120046821  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120032580  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
120044645  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
120034160  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
120030095  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
120042789  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
120044712  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
120045718  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
120031749  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
120049898  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
120052380  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
120066626  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
120058873  wiskott-Aldrich syndrome protein-like isoform X1 [KO:K05747]
120061160  wiskott-Aldrich syndrome protein homolog [KO:K05747]
120048448  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
120030042  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120030940  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120043715  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
120045975  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120047266  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120060841  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120060842  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
120019331  wiskott-Aldrich syndrome protein family member 1-like [KO:K05753]
120024477  wasf1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
120022535  wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
120026949  wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
120021099  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120021885  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120041400  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120027953  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
120049822  zgc:109889; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
120056646  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120050334  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120057582  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
120019714  afadin-like isoform X1 [KO:K05702]
120024176  afadin-like isoform X1 [KO:K05702]
120060078  afadin-like [KO:K05702]
120051542  LIM domain only protein 7-like [KO:K06084]
120058170  LIM domain only protein 7-like isoform X1 [KO:K06084]
120064476  LIM domain only protein 7-like isoform X1 [KO:K06084]
120020242  ssx2ipa; synovial sarcoma, X breakpoint 2 interacting protein a isoform X1 [KO:K06085]
120056001  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
120054589  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
120017386  sorbin and SH3 domain-containing protein 1-like [KO:K06086]
120046464  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
120018314  alpha-actinin-4-like isoform X1 [KO:K05699]
120028814  alpha-actinin-4 isoform X1 [KO:K05699]
120059730  actn1; alpha-actinin-1 [KO:K05699]
120030070  vinculin-like [KO:K05700]
120045574  vinculin-like isoform X1 [KO:K05700]
120046740  vinculin [KO:K05700]
120025359  tight junction protein ZO-1-like isoform X1 [KO:K05701]
120046404  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
120051673  tjp1b; tight junction protein ZO-1 [KO:K05701]
120065974  tight junction protein ZO-1-like [KO:K05701]
120024733  B-cadherin-like isoform X1 [KO:K05689]
120046244  B-cadherin-like [KO:K05689]
120048086  catenin delta-1-like [KO:K05690]
120042355  ctnnd1; catenin delta-1 isoform X1 [KO:K05690]
120062288  catenin delta-1-like isoform X1 [KO:K05690]
120031679  ctnnb1; catenin beta-1 [KO:K02105]
120035090  catenin alpha-2 isoform X1 [KO:K05691]
120062570  ctnna1; catenin alpha-1 isoform X1 [KO:K05691]
120052780  catenin alpha-2-like isoform X1 [KO:K05691]
120041380  actin, non-muscle 6.2 isoform X1 [KO:K05692]
120043634  actin, cytoplasmic 1 [KO:K05692]
120038727  actin, cytoplasmic 1-like [KO:K05692]
120042723  actin, non-muscle 6.2 isoform X1 [KO:K05692]
120063372  transforming protein RhoA-like [KO:K04513]
120065029  rho-related GTP-binding protein RhoA-D [KO:K04513]
120059011  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
120065359  transforming protein RhoA-like [KO:K04513]
120059302  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
120059445  rho-related GTP-binding protein RhoA-B [KO:K04513]
120061242  rho-related GTP-binding protein RhoA-C [KO:K04513]
120061269  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120019057  acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
120028099  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
120051029  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
120041301  receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
120066338  receptor-type tyrosine-protein phosphatase beta-like isoform X1 [KO:K05694] [EC:3.1.3.48]
120054150  receptor-type tyrosine-protein phosphatase beta-like isoform X1 [KO:K05694] [EC:3.1.3.48]
120051885  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
120055014  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
120055420  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
120031560  tyrosine-protein phosphatase non-receptor type 2-like isoform X1 [KO:K05696] [EC:3.1.3.48]
120059244  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
120061131  tyrosine-protein phosphatase non-receptor type 1-like [KO:K05696] [EC:3.1.3.48]
120048592  tyrosine-protein phosphatase non-receptor type 6-like isoform X1 [KO:K05697] [EC:3.1.3.48]
120048714  tyrosine-protein phosphatase non-receptor type 6-like isoform X1 [KO:K05697] [EC:3.1.3.48]
120052370  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
120066575  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
120022434  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
120039607  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
120024986  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
120042804  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
120026463  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
120026983  zgc:86598; STKc_CK2_alpha domain-containing protein isoform X1 [KO:K03097] [EC:2.7.11.1]
120036657  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
120065426  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
120066185  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
120053832  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
120022128  casein kinase II subunit beta [KO:K03115]
120039604  casein kinase II subunit beta-like [KO:K03115]
120027329  casein kinase II subunit beta [KO:K03115]
120036652  casein kinase II subunit beta-like [KO:K03115]
120044389  tcf7; transcription factor 7 [KO:K02620]
120056778  transcription factor 7-like 2 [KO:K02620]
120020954  transcription factor 7-like 1-B isoform X1 [KO:K04490]
120021019  transcription factor 7-like 1-B isoform X1 [KO:K04490]
120026317  transcription factor 7-like 1-B isoform X1 [KO:K04490]
120063242  transcription factor 7-like 1-B isoform X1 [KO:K04490]
120046309  transcription factor 7-like 2 isoform X1 [KO:K04491]
120029841  transcription factor 7-like 2 isoform X1 [KO:K04491]
120034764  lymphoid enhancer-binding factor 1-like [KO:K04492]
120035026  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
120065838  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
120053452  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120020095  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120056144  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
120052701  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120055081  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
120041135  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
120054155  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
120020248  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
120028154  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
120055996  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120051015  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
120046383  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120021867  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
120025797  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
120063215  fgfr1a; fibroblast growth factor receptor 1-A [KO:K04362] [EC:2.7.10.1]
120066669  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
120026308  fer; tyrosine-protein kinase Fer isoform X1 [KO:K08889] [EC:2.7.10.2]
120044955  tyrosine-protein kinase Fer-like [KO:K08889] [EC:2.7.10.2]
120019668  tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
120024183  tyrosine-protein kinase Fyn-like [KO:K05703] [EC:2.7.10.2]
120027831  tyrosine-protein kinase Yes-like [KO:K05705] [EC:2.7.10.2]
120051153  tyrosine-protein kinase yes [KO:K05705] [EC:2.7.10.2]
120042809  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120033084  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120037194  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120052722  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120020050  zinc finger protein SNAI2 [KO:K05706]
120055588  zinc finger protein SNAI2-like [KO:K05706]
120024954  protein snail homolog Sna-like [KO:K05707]
120065695  snai1a; snail family zinc finger 1a [KO:K05707]
120060784  snai1b; snail family zinc finger 1b [KO:K05707]
120020326  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120028096  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120051069  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
120055556  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120022652  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120027347  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
120063757  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120057931  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120038266  mothers against decapentaplegic homolog 3-like [KO:K23605]
120049742  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
120022602  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
120048474  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
120031528  mothers against decapentaplegic homolog 4-like [KO:K04501]
120025700  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
120043826  smad4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
120045007  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
120027415  mothers against decapentaplegic homolog 4-like [KO:K04501]
120017575  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
120041333  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
120034140  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
120046778  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
120029569  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
120037607  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
120019658  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
120023627  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
120024287  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
120059771  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
120018106  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
120033006  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
120028227  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120052706  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
120024937  cadherin-5-like [KO:K06533]
120046202  cadherin-5-like [KO:K06533]
120064208  protein HEG-like isoform X1 [KO:K24472]
120058357  heg1; protein HEG [KO:K24472]
120022569  krev interaction trapped protein 1 [KO:K17705]
120027365  krev interaction trapped protein 1-like isoform X1 [KO:K17705]
120018011  programmed cell death protein 10 [KO:K18269]
120033559  programmed cell death protein 10-B-like isoform X1 [KO:K18269]
120035936  programmed cell death protein 10-like isoform X1 [KO:K18269]
120051360  programmed cell death protein 10-B-like [KO:K18269]
120039033  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
120032501  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
120034150  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
120065829  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
120058606  ras-related protein Rap-1A-like [KO:K04353]
120065036  ras-related protein Rap-1A-like [KO:K04353]
120059240  ras-related protein Rap-1A-like [KO:K04353]
120061134  ras-related protein O-Krev isoform X1 [KO:K04353]
120050139  ras-related protein Rap-1b [KO:K07836]
120030853  ras-interacting protein 1-like isoform X1 [KO:K26417]
120048693  rasip1; ras-interacting protein 1 [KO:K26417]
120034245  ras-associating and dilute domain-containing protein-like isoform X1 [KO:K26418]
120040056  ras-associating and dilute domain-containing protein-like [KO:K26418]
120029635  si:ch211-176g6.2; ras-interacting protein 1 [KO:K26418]
120020685  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
120039821  rho GTPase-activating protein 29-like [KO:K20644]
120028120  arhgap29a; rho GTPase-activating protein 29 isoform X1 [KO:K20644]
120050903  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
120020258  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.39]
120055988  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.39]
120023102  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
120019239  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.39]
120024155  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
120060381  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
120021445  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120025564  LOW QUALITY PROTEIN: myosin light chain 5-like [KO:K12753]
120062793  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
120055469  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
120064176  myosin regulatory light polypeptide 9 [KO:K12755]
120065397  myosin regulatory light polypeptide 9 [KO:K12755]
120044335  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
120056508  myl10; myosin regulatory light chain 10 [KO:K12756]
120027963  myosin regulatory light polypeptide 9-like [KO:K12757]
120051148  myosin regulatory light polypeptide 9 [KO:K12757]
120040487  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
120034559  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
120045550  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
Reference
PMID:15001769
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
PMID:10204118
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
PMID:10959047
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
PMID:15489912
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
PMID:11171368
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Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
PMID:11984870
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
PMID:12640114
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Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
PMID:14623871
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Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
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J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
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PMID:11703922
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
PMID:12665527
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
PMID:10890911
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
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Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
snh04010  MAPK signaling pathway
snh04060  Cytokine-cytokine receptor interaction
snh04310  Wnt signaling pathway
snh04350  TGF-beta signaling pathway
snh04530  Tight junction
snh04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
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