Entry Name Osteoclast differentiation - Pteropus vampyrus (large flying fox)
Description The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Organism Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene 105288418 TREM2; triggering receptor expressed on myeloid cells 2 isoform X1 [KO:K14378 ]
105288852 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105289309 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
105289440 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
105291003 MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455 ]
105292242 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
105292754 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
105293029 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
105293031 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105293353 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
105294623 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
105295979 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
105296040 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105296533 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105296605 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105297143 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
105298074 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
105298404 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
105298465 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
105298742 FHL2; four and a half LIM domains protein 2 isoform X2 [KO:K14380 ]
105299024 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
105299371 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
105302576 STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221 ]
105303020 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
105307215 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105307575 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105308956 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
105309465 OSCAR; osteoclast-associated immunoglobulin-like receptor [KO:K14377 ]
105309663 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Takayanagi H, Sato K, Takaoka A, Taniguchi T
Title Interplay between interferon and other cytokine systems in bone metabolism.
Journal Reference Authors Takayanagi H
Title New immune connections in osteoclast formation.
Journal Reference Authors Nakashima T, Takayanagi H
Title Osteoimmunology: crosstalk between the immune and bone systems.
Journal Reference Authors Caetano-Lopes J, Canhao H, Fonseca JE
Title Osteoimmunology--the hidden immune regulation of bone.
Journal Reference Authors Lorenzo J, Horowitz M, Choi Y
Title Osteoimmunology: interactions of the bone and immune system.
Journal Reference Authors David JP
Title Osteoimmunology: a view from the bone.
Journal Reference Authors Jimi E, Ghosh S
Title Role of nuclear factor-kappaB in the immune system and bone.
Journal Reference Authors Boyle WJ, Simonet WS, Lacey DL
Title Osteoclast differentiation and activation.
Journal Reference Authors Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
Title TRAFs in RANK signaling.
Journal Reference Authors Baron R
Title Arming the osteoclast.
Journal Reference Authors Takayanagi H
Title Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
Journal Reference Authors Krum SA, Chang J, Miranda-Carboni G, Wang CY
Title Novel functions for NFkappaB: inhibition of bone formation.
Journal Reference Authors Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
Title A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
Journal Reference Authors Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
Title Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Journal Reference Authors Takayanagi H, Kim S, Koga T, Taniguchi T
Title Stat1-mediated cytoplasmic attenuation in osteoimmunology.
Journal Reference Authors Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
Title Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Journal Reference Authors Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
Title FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Journal Reference Authors Takayanagi H, Kim S, Taniguchi T
Title Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
Journal Related KO pathway
