KEGG   PATHWAY: pvp04630
Entry
pvp04630                    Pathway                                
Name
JAK-STAT signaling pathway - Pteropus vampyrus (large flying fox)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04630  JAK-STAT signaling pathway
pvp04630

Other DBs
GO: 0007259
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105302208  IL2; interleukin-2 [KO:K05429]
105293550  IL4; interleukin-4 [KO:K05430]
105302950  IL7; interleukin-7 isoform X1 [KO:K05431]
105293649  IL9; interleukin-9 [KO:K05432]
105301205  IL15; interleukin-15 isoform X1 [KO:K05433]
105302207  IL21; interleukin-21 [KO:K05434]
105295491  TSLP; thymic stromal lymphopoietin [KO:K05436]
105307737  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105311493  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105299605  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105303367  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105305877  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105303368  LOW QUALITY PROTEIN: interleukin-9 receptor-like [KO:K05073]
105307744  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
105303236  IL21R; interleukin-21 receptor [KO:K05075]
105309602  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
105293643  interleukin-3-like [KO:K04736]
105293547  IL5; interleukin-5 [KO:K05428]
105293539  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105308004  interleukin-3 receptor subunit alpha-like [KO:K04737]
105295168  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
105308006  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
105288307  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105304909  IL11; interleukin-11 isoform X1 [KO:K05417]
105293549  IL13; LOW QUALITY PROTEIN: interleukin-13 [KO:K05435]
105304605  IL27; interleukin-27 subunit alpha [KO:K22629]
111736927  IL31; interleukin-31 isoform X1 [KO:K22631]
105300916  OSM; oncostatin-M [KO:K05418]
105300917  LIF; leukemia inhibitory factor [KO:K05419]
105309552  CNTF; ciliary neurotrophic factor [KO:K05420]
105304593  cardiotrophin-1 [KO:K05422]
105304592  cardiotrophin-2-like [KO:K24382]
105309920  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
105296452  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105299364  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
105306439  IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056]
105305539  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
105309858  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
105308496  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
105299368  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
105299113  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
105299114  LIFR; leukemia inhibitory factor receptor [KO:K05058]
105306433  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
105308926  IL10; interleukin-10 [KO:K05443]
105308923  IL19; interleukin-19 isoform X2 [KO:K05444]
105301280  IL22; interleukin-22 [KO:K05445]
105308922  IL20; interleukin-20 [KO:K22667]
105308920  IL24; interleukin-24 [KO:K22668]
105301273  IL26; interleukin-26 [KO:K05446]
105309256  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
111728848  interleukin-10 receptor subunit beta-like [KO:K05135]
105295863  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
105289470  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
105300827  IL20RB; interleukin-20 receptor subunit beta isoform X5 [KO:K05137]
105290462  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
105289522  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
105305876  IL12A; interleukin-12 subunit alpha [KO:K05406]
105289903  IL12B; interleukin-12 subunit beta [KO:K05425]
105302575  IL23A; interleukin-23 subunit alpha [KO:K05426]
105296672  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
105298373  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
105298385  IL23R; interleukin-23 receptor [KO:K05065]
105299734  EPO; erythropoietin [KO:K05437]
105297761  somatotropin [KO:K05438]
105306493  PRL; prolactin [KO:K05439]
105306931  THPO; thrombopoietin isoform X1 [KO:K06854]
105307511  CSF3; granulocyte colony-stimulating factor [KO:K05423]
105290178  LEP; leptin [KO:K05424]
105305625  EPOR; erythropoietin receptor [KO:K05079]
105299105  GHR; growth hormone receptor [KO:K05080]
105305879  PRLR; prolactin receptor [KO:K05081]
105297085  MPL; thrombopoietin receptor [KO:K05082]
105290707  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
105298364  LEPR; leptin receptor [KO:K05062]
105298437  interferon alpha-1-like [KO:K05414]
105309143  interferon alpha-4-like [KO:K05414]
105309144  interferon alpha-4-like [KO:K05414]
105309148  interferon alpha-10-like [KO:K05414]
105309141  IFNB1; interferon beta [KO:K05415]
105298438  IFNE; interferon epsilon isoform X1 [KO:K05442]
105308728  IFNK; interferon kappa [KO:K05441]
105310596  interferon lambda-3-like [KO:K05447]
105309146  interferon tau-1-like [KO:K05440]
105309149  interferon omega-1-like [KO:K05440]
105310428  interferon omega-1-like [KO:K05440]
105311508  interferon tau-1-like [KO:K05440]
105311511  interferon omega-1-like [KO:K05440]
105310336  interferon omega-2-like [KO:K05440]
105310700  interferon tau-1-like [KO:K05440]
105311676  interferon tau-1-like [KO:K05440]
105295861  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105301255  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105290463  IFNLR1; interferon lambda receptor 1 [KO:K05140]
105301262  IFNG; interferon gamma [KO:K04687]
105289469  IFNGR1; interferon gamma receptor 1 [KO:K05132]
105295851  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105306141  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105298360  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105296612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105305596  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105289309  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105302576  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
105306294  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105289302  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
105306335  signal transducer and activator of transcription 5A-like [KO:K11223]
105306336  signal transducer and activator of transcription 5B [KO:K11224]
105302552  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
105309384  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
105295182  CISH; LOW QUALITY PROTEIN: cytokine-inducible SH2-containing protein [KO:K04701]
105290926  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
105293246  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
105293447  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105309162  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
105292917  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
105308378  SOCS7; suppressor of cytokine signaling 7 isoform X2 [KO:K04699]
105296105  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105303816  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105288389  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105307128  uncharacterized protein LOC105307128 [KO:K04503]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105288383  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105298172  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
105298171  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
105303469  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
105291531  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
105294913  STAM; signal transducing adapter molecule 1 [KO:K04705]
105306359  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
105295941  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
105298051  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
105303098  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105310271  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
105292698  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063] [EC:2.3.2.-]
105296186  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
105306728  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
105307040  FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365]
105289236  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
105309828  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
pvp04010  MAPK signaling pathway
pvp04060  Cytokine-cytokine receptor interaction
pvp04110  Cell cycle
pvp04120  Ubiquitin mediated proteolysis
pvp04151  PI3K-Akt signaling pathway
pvp04210  Apoptosis
KO pathway
ko04630   
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