KEGG   PATHWAY: pvp04714
Entry
pvp04714                    Pathway                                
Name
Thermogenesis - Pteropus vampyrus (large flying fox)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
pvp04714  Thermogenesis
pvp04714

Other DBs
GO: 1990845
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288522  ATP5ME; LOW QUALITY PROTEIN: ATP synthase subunit e, mitochondrial [KO:K02129]
105288555  [KO:K11265] [EC:4.6.1.1]
105288658  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial isoform X1 [KO:K18159]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289266  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105289274  [KO:K02266]
105289337  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105289653  [KO:K18183]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105290042  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
105290070  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105290165  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X2 [KO:K03949]
105290188  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105290195  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105290441  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
105290495  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105290496  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
105290810  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105291020  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
105291023  GCG; glucagon isoform X1 [KO:K05259]
105291053  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X2 [KO:K07200]
105291280  [KO:K02257] [EC:2.5.1.141]
105291484  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
105291606  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105291624  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105291714  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105292334  [KO:K17797]
105292433  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
105292505  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
105292546  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105292672  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105292768  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105292810  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105292938  [KO:K02270]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105292962  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
105293145  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
105293217  [KO:K09047]
105293278  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105293340  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105293538  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
105293619  KDM3B; lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
105293856  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
105293861  KLB; beta-klotho isoform X1 [KO:K22404]
105293916  [KO:K02271]
105294032  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294061  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105294330  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105294426  NPPA; natriuretic peptides A [KO:K12334]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294706  ACSL1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
105294928  [KO:K02271]
105295382  [KO:K02258]
105295511  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
105295596  RPS6; 40S ribosomal protein S6 [KO:K02991]
105295633  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105295843  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105295986  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105296083  [KO:K04632]
105296096  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105296192  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105296460  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296558  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X2 [KO:K11353]
105296904  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105296985  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
105297147  [KO:K00416]
105297518  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105297531  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
105297557  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
105297560  [KO:K18181]
105297603  [KO:K03968]
105297723  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
105297801  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
105297836  [KO:K02273]
105298025  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105298131  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
105298404  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105298415  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105298533  KDM3A; LOW QUALITY PROTEIN: lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
105298655  TSC1; hamartin isoform X1 [KO:K07206]
105298695  [KO:K18184]
105298839  [KO:K02263]
105298877  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
105298970  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X2 [KO:K08766] [EC:2.3.1.21]
105298977  [KO:K18180]
105298997  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105299024  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
105299096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105299204  PRDM16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
105299260  DPF3; zinc finger protein DPF3 [KO:K22198]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105299739  ACTL6B; actin-like protein 6B [KO:K11652]
105300178  ADRB3; beta-3 adrenergic receptor [KO:K04143]
105300197  DPF1; zinc finger protein neuro-d4 isoform X3 [KO:K22198]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105300317  [KO:K18173]
105300590  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
105300597  [KO:K00417]
105300789  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X2 [KO:K03957]
105300868  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105300922  [KO:K00419]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301070  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301154  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
105301186  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105301194  [KO:K00411] [EC:7.1.1.8]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105301308  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105301309  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105301347  [KO:K18179]
105301406  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
105301508  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
105301572  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
105301586  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
105301613  [KO:K02260]
105301667  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105301726  AKT1S1; proline-rich AKT1 substrate 1 isoform X2 [KO:K16184]
105301787  [KO:K19524] [EC:2.3.1.21]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105301970  [KO:K00413]
105302100  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105302219  [KO:K00420]
105302238  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
105302295  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
105302368  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
105302372  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
105302407  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
105302414  [KO:K00414]
105302549  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
105302566  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105302586  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
105302646  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105302819  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
105302898  [KO:K02268]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105303324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
105303335  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105303344  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105303396  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105303403  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105303625  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
105303638  [KO:K18177]
105303760  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X3 [KO:K11650]
105303777  RHEB; GTP-binding protein Rheb [KO:K07208]
105303778  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
105303918  [KO:K02272]
105304165  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105304499  [KO:K02266]
105304613  [KO:K02259] [EC:1.17.99.9]
105304627  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105304821  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
105304910  [KO:K02267]
105305186  PLIN1; perilipin-1 [KO:K08768]
105305214  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105305394  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
105305449  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105305502  [KO:K02263]
105305558  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105305662  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
105305799  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105305945  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
105306053  [KO:K00415]
105306167  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105306271  [KO:K18175]
105306380  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105306407  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105306466  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
105306550  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105306559  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105306564  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105306643  [KO:K02267]
105306745  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105306746  SIRT6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
105306778  [KO:K18178]
105306783  [KO:K02265]
105306845  [KO:K02264]
105306976  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105307242  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105307364  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
105307369  [KO:K04373] [EC:2.7.11.1]
105307507  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105307528  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X3 [KO:K11651]
105307710  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105307875  [KO:K02270]
105307876  ACTL6A; actin-like protein 6A [KO:K11340]
105307890  [KO:K02270]
105308270  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
105308283  [KO:K04441] [EC:2.7.11.24]
105308299  [KO:K08041] [EC:4.6.1.1]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308512  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105308785  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
105308883  [KO:K02271]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105309436  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
105309466  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105310078  [KO:K18182]
105310195  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
105311019  [KO:K00418]
105311066  [KO:K03954]
105311245  [KO:K16622]
111734519  [KO:K03939]
111742104  NPPB; natriuretic peptides B isoform X1 [KO:K12335]
111742157  [KO:K03944]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
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Mol Cell Biol 25:5466-79 (2005)
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Nat Commun 7:11158 (2016)
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Nat Commun 6:7052 (2015)
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Mol Cell 57:235-46 (2015)
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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
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Nat Rev Endocrinol 14:77-87 (2018)
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Nat Rev Cardiol 11:403-12 (2014)
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The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
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Mol Aspects Med 32:223-33 (2011)
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Nat Rev Endocrinol 11:617-25 (2015)
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Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
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Biochem Biophys Rep 10:32-38 (2017)
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Related
pathway
pvp00020  Citrate cycle (TCA cycle)
pvp00190  Oxidative phosphorylation
pvp04010  MAPK signaling pathway
pvp04022  cGMP-PKG signaling pathway
pvp04024  cAMP signaling pathway
pvp04150  mTOR signaling pathway
pvp04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   

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