KEGG   PATHWAY: rtp04217
Entry
rtp04217                    Pathway                                
Name
Necroptosis - Rhincodon typus (whale shark)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
rtp04217  Necroptosis
rtp04217

Organism
Rhincodon typus (whale shark) [GN:rtp]
Gene
109910851  tumor necrosis factor-like [KO:K03156]
109910853  tumor necrosis factor-like [KO:K03156]
109916901  lymphotoxin-alpha-like [KO:K03156]
125488288  tumor necrosis factor-like [KO:K03156]
109910852  tumor necrosis factor-like [KO:K03156]
109922055  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109916783  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109936083  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109931682  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
125481585  inhibitor of apoptosis protein-like [KO:K16060]
109919537  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
109938984  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
109920465  si:dkey-181m9.8; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
109923181  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
109912778  spata2; spermatogenesis-associated protein 2 [KO:K17595]
109916570  spata2l; spermatogenesis associated 2-like [KO:K17595]
109921010  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
109919463  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X4 [KO:K08601] [EC:3.4.19.12]
109916032  cylda; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
109916874  fadd; protein FADD [KO:K02373]
109929740  caspase-8-like [KO:K04398] [EC:3.4.22.61]
109929742  CASP8 and FADD-like apoptosis regulator [KO:K04724]
109927717  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109912036  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
109922295  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109924065  slc25a4; ADP/ATP translocase 1 [KO:K05863]
109914009  slc25a5; ADP/ATP translocase 2 [KO:K05863]
109928789  ADP/ATP translocase 4 [KO:K05863]
109917841  ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
109928316  voltage-dependent anion-selective channel protein 1 isoform X3 [KO:K05862]
109935019  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109927500  vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
109920846  glud1a; glutamate dehydrogenase 1a [KO:K00261] [EC:1.4.1.3]
109913773  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
109915497  glutamine synthetase, mitochondrial isoform X1 [KO:K01915] [EC:6.3.1.2]
109914918  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
109926084  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
109927876  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109917844  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109917855  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109931175  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109931179  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109925126  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109932343  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109932347  ferritin, heavy subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109932348  ferritin, heavy subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109932349  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109932352  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109932353  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109932354  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
109932360  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109917684  ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
109917686  ferritin, heavy subunit-like isoform X2 [KO:K00522] [EC:1.16.3.1]
109917687  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109917690  ferritin heavy chain A-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109917691  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
109931440  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109921505  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
109921506  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109921508  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
109921509  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
109930384  ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
109930385  ferritin heavy chain A-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109930388  ferritin, middle subunit-like isoform X2 [KO:K00522] [EC:1.16.3.1]
109930389  ferritin heavy chain A-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109936636  ferritin, middle subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109936638  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109938383  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109938384  ferritin, heavy subunit-like isoform X4 [KO:K00522] [EC:1.16.3.1]
109938385  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109938387  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109938388  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109938393  ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
109938394  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109924455  ferritin, lower subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109932338  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109928237  fth1a; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
109937464  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109937466  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109937467  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
125487180  ferritin, higher subunit-like [KO:K00522] [EC:1.16.3.1]
125487182  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125487183  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
125487184  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
125487185  ferritin, higher subunit-like [KO:K00522] [EC:1.16.3.1]
125487186  LOW QUALITY PROTEIN: ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
125481897  LOW QUALITY PROTEIN: ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
125481898  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109936637  LOW QUALITY PROTEIN: ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
125482639  ferritin heavy chain B-like [KO:K00522] [EC:1.16.3.1]
109933766  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109938350  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
109915552  mixed lineage kinase domain-like protein isoform X2 [KO:K08849] [EC:2.7.11.1]
109935638  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
109915648  dnm1l; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
109916765  caspase-1-like isoform X3 [KO:K01370] [EC:3.4.22.36]
109919637  chmp2a; charged multivesicular body protein 2a [KO:K12191]
109915038  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
109937980  charged multivesicular body protein 4c-like [KO:K12194]
109921574  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
109916984  chmp6b; charged multivesicular body protein 6-A [KO:K12195]
109930206  vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
109924156  vacuolar protein sorting-associated protein 4A [KO:K12196]
109919393  chmp1b; charged multivesicular body protein 1b [KO:K12197]
109916599  chmp1a; charged multivesicular body protein 1a isoform X1 [KO:K12197]
109917957  chmp5b; charged multivesicular body protein 5 [KO:K12198]
109920651  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
109938453  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
109930946  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109930951  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109929457  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
109937603  interferon a3-like [KO:K05414]
109937604  interferon alpha-F-like [KO:K05414]
109937605  interferon alpha-10-like [KO:K05414]
109937655  interferon alpha-1/13-like [KO:K05414]
109937606  interferon beta-like [KO:K05414]
109928154  interferon gamma-like [KO:K04687]
109928467  uncharacterized protein LOC109928467 isoform X1 [KO:K05131]
109918768  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109934192  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
109915588  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109920367  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109928447  signal transducer and activator of transcription 3 [KO:K04692]
109920378  signal transducer and activator of transcription 4 isoform X2 [KO:K11222]
109926024  signal transducer and activator of transcription 3.1-like [KO:K11222]
109929795  stat5a; signal transducer and activator of transcription 5A isoform X1 [KO:K11224]
109918246  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
109919526  toll-like receptor 3 [KO:K05401]
109927682  sqstm1; sequestosome-1 isoform X2 [KO:K14381]
109921310  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109936404  heat shock protein HSP 90-alpha [KO:K04079]
109916597  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
109918844  zgc:153993; apoptosis regulator BAX [KO:K02159]
109931829  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
109931204  late histone H2A.2.2-like [KO:K11251]
109934142  late histone H2A.2.2-like [KO:K11251]
109914613  histone H2A-like [KO:K11251]
109927870  late histone H2A.2.2-like isoform X1 [KO:K11251]
109913403  core histone macro-H2A.2 isoform X4 [KO:K11251]
109925004  histone H2A-IV-like [KO:K11251]
109915101  histone H2A [KO:K11251]
109936483  late histone H2A.2.2 [KO:K11251]
109925958  late histone H2A.2.2-like [KO:K11251]
109932858  late histone H2A.2.2-like [KO:K11251]
109918192  histone H2A-like [KO:K11251]
109928913  late histone H2A.2.2-like [KO:K11251]
109932483  late histone H2A.2.2-like [KO:K11251]
109932322  late histone H2A.2.2-like [KO:K11251]
109930663  late histone H2A.2.2-like [KO:K11251]
109913028  late histone H2A.2.2-like [KO:K11251]
109928055  late histone H2A.2.2-like [KO:K11251]
109913697  core histone macro-H2A.1 isoform X1 [KO:K11251]
125488117  histone H2A type 2-B-like [KO:K11251]
109932903  histone H2A, sperm-like [KO:K11251]
125488130  late histone H2A.2.2-like [KO:K11251]
109928048  late histone H2A.2.2-like [KO:K11251]
125488144  late histone H2A.2.2-like [KO:K11251]
125488146  late histone H2A.2.2-like [KO:K11251]
109926808  late histone H2A.2.2-like [KO:K11251]
125488148  histone H2A-like [KO:K11251]
109932701  late histone H2A.2.2-like [KO:K11251]
125488152  late histone H2A.2.2-like [KO:K11251]
109936188  late histone H2A.2.2-like [KO:K11251]
109932866  late histone H2A.2.2-like [KO:K11251]
125481138  late histone H2A.2.2-like [KO:K11251]
109929967  late histone H2A.2.2-like [KO:K11251]
125481650  histone H2A-like [KO:K11251]
125482490  histone H2A-like [KO:K11251]
109932484  late histone H2A.2.2-like [KO:K11251]
109922366  histone H2A.V [KO:K11251]
109926813  histone H2B 7-like [KO:K11251]
109935270  histone H2A.Z [KO:K11251]
109930204  apoptosis regulator Bcl-2-like isoform X2 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
rtp00250  Alanine, aspartate and glutamate metabolism
rtp04210  Apoptosis
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system