KEGG   PATHWAY: scan04020
Entry
scan04020                   Pathway                                
Name
Calcium signaling pathway - Serinus canaria (common canary)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
scan04020  Calcium signaling pathway
scan04020

Other DBs
GO: 0019722
Organism
Serinus canaria (common canary) [GN:scan]
Gene
103826617  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
103825387  sodium/calcium exchanger 2-like [KO:K05849]
103821334  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
103824510  ATP2B4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
103813406  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
103816942  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
103818527  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103826586  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103818244  ADORA2A; adenosine receptor A2a [KO:K04266]
103820144  ADORA2B; adenosine receptor A2b [KO:K04267]
103814126  ADRB1; beta-1 adrenergic receptor [KO:K04141]
103817524  ADRB2; beta-2 adrenergic receptor [KO:K04142]
103822749  ADRB3; beta-3 adrenergic receptor [KO:K04143]
103824092  DRD1; D(1A) dopamine receptor [KO:K04144]
103814180  D(1)-like dopamine receptor [KO:K05840]
103826138  DRD5; D(1B) dopamine receptor [KO:K05840]
108963590  D(1) dopamine receptor-like [KO:K05840]
103817501  HRH2; histamine H2 receptor [KO:K04150]
103826101  probable G-protein coupled receptor No9 [KO:K04150]
103817535  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
103814634  5-hydroxytryptamine receptor 5B-like [KO:K04161]
103813063  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
103824358  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
103814182  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
103823091  5-hydroxytryptamine receptor 7-like [KO:K04163]
103818880  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103826629  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
103819377  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103815408  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103816806  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103816719  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
103817765  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103814927  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103818356  PLN; cardiac phospholamban [KO:K05852]
103827294  SLN; sarcolipin [KO:K22642]
103818170  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103820058  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
103823821  LOW QUALITY PROTEIN: stromal interaction molecule 1 [KO:K16059]
115484828  stromal interaction molecule 1-like isoform X1 [KO:K16059]
103824671  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
103818164  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
103820071  ORAI2; protein orai-2 [KO:K16057]
103820462  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103816992  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103822432  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
103819171  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103823392  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103819981  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X14 [KO:K04854]
103817830  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103813612  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103821221  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
103816170  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
103819186  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
103817733  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
103813324  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103819989  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
103821048  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
103822042  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
103820059  P2RX1; P2X purinoceptor 1 [KO:K05215]
103827062  P2RX3; P2X purinoceptor 3 [KO:K05217]
103818168  P2RX4; P2X purinoceptor 4 [KO:K05218]
103820151  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
103818208  P2X purinoceptor 6 [KO:K05221]
103818574  RYR2; ryanodine receptor 2 [KO:K04962]
103826585  RYR3; ryanodine receptor 3 [KO:K04963]
103821993  TRDN; triadin [KO:K23449]
103827106  CASQ2; calsequestrin-2 [KO:K23445]
103812527  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X7 [KO:K00476] [EC:1.14.11.16]
103816566  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
103812573  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
103819622  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103822708  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
103817536  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
103823103  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
103815406  AGTR1; type-1 angiotensin II receptor [KO:K04166]
103826077  EDNRA; endothelin-1 receptor [KO:K04197]
103812274  EDNRB; endothelin receptor type B [KO:K04198]
103816487  endothelin receptor type B-like [KO:K04198]
103819537  F2R; proteinase-activated receptor 1 [KO:K03914]
103818453  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
103827248  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
103815825  GRPR; gastrin-releasing peptide receptor [KO:K04169]
103816939  HRH1; histamine H1 receptor [KO:K04149]
103815365  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
103816352  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103827411  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
103819300  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
103818868  NTSR1; neurotensin receptor type 1 [KO:K04211]
103824132  OXTR; oxytocin receptor [KO:K04229]
103820393  AVPR1A; vasopressin V1a receptor [KO:K04226]
103822318  AVPR1B; vasopressin V1b receptor [KO:K04227]
103822624  PTAFR; platelet-activating factor receptor isoform X2 [KO:K04279]
108961816  PTGER3; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP3 subtype [KO:K04260]
103814933  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
103826882  BDKRB2; B2 bradykinin receptor isoform X2 [KO:K03915]
103824657  TACR1; substance-P receptor [KO:K04222]
103823748  TACR2; substance-K receptor [KO:K04223]
103826021  TACR3; neuromedin-K receptor [KO:K04224]
103821980  TBXA2R; thromboxane A2 receptor isoform X2 [KO:K04264]
103816599  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
103818805  thyrotropin-releasing hormone receptor-like [KO:K04282]
103824660  CCKAR; cholecystokinin receptor type A [KO:K04194]
103814274  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103823251  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103824735  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
103821936  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103826255  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103817870  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103813271  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103812525  PDGFD; platelet-derived growth factor D [KO:K05450]
103826223  PDGFC; platelet-derived growth factor C [KO:K05450]
103817397  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103821418  FGF2; fibroblast growth factor 2 [KO:K18497]
103816506  FGF16; fibroblast growth factor 16 [KO:K04358]
103819601  FGF6; fibroblast growth factor 6 [KO:K04358]
103816025  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103813872  FGF8; fibroblast growth factor 8 isoform X2 [KO:K04358]
103823450  FGF5; fibroblast growth factor 5 [KO:K04358]
103827318  FGF9; fibroblast growth factor 9 [KO:K04358]
103826197  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
103822218  FGF4; fibroblast growth factor 4 [KO:K04358]
103822219  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103823777  FGF18; fibroblast growth factor 18 isoform X4 [KO:K04358]
115484358  FGF22; fibroblast growth factor 22 [KO:K04358]
115485473  FGF19; LOW QUALITY PROTEIN: fibroblast growth factor 19 [KO:K22603]
103819695  FGF23; fibroblast growth factor 23 [KO:K22428]
103817849  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103815820  VEGFD; vascular endothelial growth factor D [KO:K05449]
103825795  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
103822331  NGF; beta-nerve growth factor [KO:K02582]
103813737  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103816955  MST1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
103821005  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103819418  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
103821628  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103814752  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103825217  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103817301  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103822693  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103813785  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103826117  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103817508  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103827338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103816498  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
103817296  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
103825225  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103824820  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103822953  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
103816080  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
103813465  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103817131  MST1R; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
103814210  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
103825246  LOW QUALITY PROTEIN: Ig heavy chain Mem5-like [KO:K06856]
103814352  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
103812698  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3 [KO:K05857] [EC:3.1.4.11]
103821776  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
103822183  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103819233  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103819309  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103818789  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
103826392  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
103816730  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103814177  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103820488  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
103823703  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103819592  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
103823305  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
103824319  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103818054  TPCN1; two pore calcium channel protein 1 isoform X2 [KO:K16896]
103822111  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
103814916  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
103814915  mucolipin-3 isoform X2 [KO:K04994]
103819871  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
103823735  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
103817251  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103814011  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103822679  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103816532  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103812627  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103825605  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103814205  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
103816983  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103818652  TNNC2; troponin C, skeletal muscle [KO:K12042]
103817225  CALM2; calmodulin-2 [KO:K02183]
103816252  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103822470  calmodulin, striated muscle [KO:K02183]
103826480  CALM1; calmodulin-1 [KO:K02183]
103820093  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
103815839  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X5 [KO:K07190]
103816295  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
103816613  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
103821775  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
103814310  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
103816608  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
103818839  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103818174  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103813567  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
103823276  CAMK1G; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
103817046  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
103817304  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
103822722  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
103815714  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
103813998  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103824116  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
103822052  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
103813987  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103826268  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103824434  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103821361  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
103823357  TFEB; transcription factor EB [KO:K15590]
103819427  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103818892  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
103816639  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103818226  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
103820198  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
103814470  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
103821175  LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
103821374  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
103826986  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
103819765  PRKCA; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
103817801  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
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