KEGG   PATHWAY: scan04810
Entry
scan04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Serinus canaria (common canary)
Class
Cellular Processes; Cell motility
Pathway map
scan04810  Regulation of actin cytoskeleton
scan04810

Other DBs
GO: 0030036
Organism
Serinus canaria (common canary) [GN:scan]
Gene
103812253  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103812334  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103812357  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103812404  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X3 [KO:K13710]
103812525  PDGFD; platelet-derived growth factor D [KO:K05450]
103812582  RGCC; regulator of cell cycle RGCC [KO:K26108]
103812718  ACTR3B; actin-related protein 3B [KO:K18584]
103812774  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
103812848  SCIN; adseverin [KO:K05768]
103812872  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
103813076  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103813103  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
103813216  MYH9; myosin-9 [KO:K10352]
103813234  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103813271  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103813426  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103813695  WASL; LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein [KO:K23612]
103813785  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103813872  FGF8; fibroblast growth factor 8 isoform X2 [KO:K04358]
103813941  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
103814000  VCL; vinculin isoform X2 [KO:K05700]
103814094  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103814274  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103814308  ITGB5; integrin beta-5 [KO:K06588]
103814310  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
103814330  MRAS; ras-related protein M-Ras [KO:K07831]
103814346  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103814382  ITGB6; integrin beta-6 [KO:K06589]
103814436  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
103814472  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
103814478  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103814560  ITGAV; integrin alpha-V [KO:K06487]
103814562  ITGB2; integrin beta-2 [KO:K06464]
103814566  NCKAP1; nck-associated protein 1 [KO:K05750]
103814567  FAM49B; protein FAM49B isoform X1 [KO:K27976]
103814579  FN1; fibronectin isoform X1 [KO:K05717]
103814631  ACTR3; actin-related protein 3 [KO:K18584]
103814710  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
103814761  PTK2; focal adhesion kinase 1 isoform X15 [KO:K05725] [EC:2.7.10.2]
103814816  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103814989  [KO:K02649]
103815053  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
103815078  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103815123  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
103815206  C8B; complement component C8 beta chain isoform X2 [KO:K03998]
103815304  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103815327  KNG1; kininogen-1 isoform X1 [KO:K03898]
103815510  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103815532  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X2 [KO:K05769]
103815558  PFN2; profilin-2 isoform X1 [KO:K05759]
103815807  TMSB4X; thymosin beta-4 [KO:K05764]
103816025  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103816115  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103816139  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X2 [KO:K16848]
103816255  ITGA11; integrin alpha-11 [KO:K06587]
103816370  [KO:K05733] [EC:2.7.11.1]
103816416  MSN; moesin isoform X1 [KO:K05763]
103816438  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103816452  DIAPH2; LOW QUALITY PROTEIN: protein diaphanous homolog 2 [KO:K05741]
103816464  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
103816506  FGF16; fibroblast growth factor 16 [KO:K04358]
103816508  [KO:K05733] [EC:2.7.11.1]
103816608  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
103816661  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
103816934  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103816985  RHOA; transforming protein RhoA [KO:K04513]
103817048  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103817103  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103817249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103817276  [KO:K05764]
103817301  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103817337  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
103817397  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103817508  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103817616  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103817617  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103817621  ACTB; actin, cytoplasmic 1 [KO:K05692]
103817628  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103817704  MYH11; myosin-11 isoform X1 [KO:K10352]
103817751  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103817870  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103817879  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103818004  CRKL; crk-like protein [KO:K04438]
103818028  LIMK2; LIM domain kinase 2 isoform X3 [KO:K05744] [EC:2.7.11.1]
103818074  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103818130  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103818146  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103818147  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103818174  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103818256  PXN; paxillin [KO:K05760]
103818322  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103818444  [KO:K05731]
103818527  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103818614  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103818668  WASF1; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103818839  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103818941  GSN; gelsolin isoform X1 [KO:K05768]
103819100  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103819113  C5; complement C5 [KO:K03994]
103819129  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103819231  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
103819286  ENAH; protein enabled homolog isoform X1 [KO:K05746]
103819418  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
103819439  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103819493  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X2 [KO:K05767]
103819537  F2R; proteinase-activated receptor 1 [KO:K03914]
103819595  KRAS; GTPase KRas [KO:K07827]
103819601  FGF6; fibroblast growth factor 6 [KO:K04358]
103819614  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103819622  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103819695  FGF23; fibroblast growth factor 23 [KO:K22428]
103819726  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103819747  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
103819902  MYH10; myosin-10 [KO:K10352]
103819970  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103820000  ITGB4; integrin beta-4 isoform X6 [KO:K06525]
103820068  MYL10; myosin regulatory light chain 10 [KO:K12756]
103820104  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
103820230  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103820304  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
103820306  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103820340  [KO:K04289]
103820586  ROCK2; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.39]
103820599  EZR; ezrin isoform X1 [KO:K08007]
103820674  FAM49A; protein FAM49A [KO:K27976]
103820781  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103821074  C9; complement component C9 isoform X2 [KO:K04000]
103821078  C7; complement component C7 [KO:K03996]
103821079  C6; complement component C6 [KO:K03995]
103821089  ITGA1; integrin alpha-1 [KO:K06480]
103821090  ITGA2; integrin alpha-2 [KO:K06481]
103821384  SOS1; son of sevenless homolog 1 [KO:K03099]
103821396  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103821418  FGF2; fibroblast growth factor 2 [KO:K18497]
103821559  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
103821681  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103821768  ITGA2B; integrin alpha-IIb [KO:K06476]
103821775  [KO:K00907] [EC:2.7.11.18]
103821825  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103821892  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X11 [KO:K00889] [EC:2.7.1.68]
103821918  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103822055  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
103822184  PAK6; serine/threonine-protein kinase PAK 6 isoform X3 [KO:K05735] [EC:2.7.11.1]
103822218  FGF4; fibroblast growth factor 4 [KO:K04358]
103822219  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103822252  SSH3; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103822255  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103822405  NRAS; GTPase NRas [KO:K07828]
103822442  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X12 [KO:K12329]
103822693  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103823048  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X4 [KO:K07532]
103823133  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103823197  [KO:K05692]
103823450  FGF5; fibroblast growth factor 5 [KO:K04358]
103823499  [KO:K27976]
103823594  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103823598  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103823660  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103823777  FGF18; fibroblast growth factor 18 isoform X4 [KO:K04358]
103823811  ITGA9; integrin alpha-9 [KO:K06585]
103824066  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
103824084  HRAS; GTPase HRas [KO:K02833]
103824159  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103824192  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103824201  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103824555  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103824821  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103824863  [KO:K05733] [EC:2.7.11.1]
103824894  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103824990  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
103825048  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103825056  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103825217  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103825237  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
103826117  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103826197  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
103826223  PDGFC; platelet-derived growth factor C [KO:K05450]
103826255  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103826388  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103826553  CFL2; cofilin-2 [KO:K05765]
103826586  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103826606  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103826681  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103826687  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103826754  INS; insulin [KO:K04526]
103826824  SOS2; son of sevenless homolog 2 [KO:K03099]
103826830  [KO:K12757]
103826849  [KO:K12757]
103826882  BDKRB2; B2 bradykinin receptor isoform X2 [KO:K03915]
103826969  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
103827032  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103827152  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103827218  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103827299  RDX; radixin isoform X1 [KO:K05762]
103827318  FGF9; fibroblast growth factor 9 [KO:K04358]
103827322  SPATA13; spermatogenesis-associated protein 13 isoform X3 [KO:K05769]
108962523  C8G; complement component C8 gamma chain [KO:K03999]
108963765  [KO:K05733] [EC:2.7.11.1]
108963847  [KO:K05733] [EC:2.7.11.1]
115483908  [KO:K02649]
115484028  [KO:K05733] [EC:2.7.11.1]
115484097  BRK1; protein BRICK1 [KO:K05752]
115484191  [KO:K26108]
115484358  FGF22; fibroblast growth factor 22 [KO:K04358]
115485136  [KO:K05733] [EC:2.7.11.1]
115485137  [KO:K05733] [EC:2.7.11.1]
115485161  [KO:K05733] [EC:2.7.11.1]
115485380  [KO:K05733] [EC:2.7.11.1]
115485473  FGF19; LOW QUALITY PROTEIN: fibroblast growth factor 19 [KO:K22603]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
scan04010  MAPK signaling pathway
scan04510  Focal adhesion
scan04520  Adherens junction
KO pathway
ko04810   

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