Entry Name Toll-like receptor signaling pathway - Sus scrofa (pig)
Description Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ssc04620 Toll-like receptor signaling pathway
Ortholog table Organism Sus scrofa (pig) [GN:
ssc ]
Gene 397303 LBP; lipopolysaccharide-binding protein precursor [KO:K05399 ]
100037938 CD14; monocyte differentiation antigen CD14 precursor [KO:K04391 ]
399541 TLR4; toll-like receptor 4 isoform 1 precursor [KO:K10160 ]
100518131 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100621789 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100622559 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100511937 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100739510 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100623707 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
396646 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
100514174 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
595129 FADD; FAS-associated death domain protein [KO:K02373 ]
396606 IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730 ] [EC:2.7.11.1 ]
100153785 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
100156182 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
751869 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
397076 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
494459 CCL3L1; C-C motif chemokine 3-like 1 precursor [KO:K05408 ]
397395 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
397161 CD80; T-lymphocyte activation antigen CD80 precursor [KO:K05412 ]
397441 CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413 ]
100153724 IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414 ]
100157766 IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414 ]
100152100 IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414 ]
100152504 IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414 ]
100157735 IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414 ]
100154938 IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414 ]
396658 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
396655 STAT1; signal transducer and activator of transcription 1 [KO:K11220 ]
396923 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
494019 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
Reference Authors Kawai T, Akira S.
Title TLR signaling.
Journal Reference Authors O'Neill LA, Bowie AG.
Title The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Journal Reference Authors Honda K, Taniguchi T.
Title IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and Type I interferons.
Journal Reference Authors Akira S, Uematsu S, Takeuchi O.
Title Pathogen recognition and innate immunity.
Journal Reference Authors Yamamoto M, Takeda K, Akira S.
Title TIR domain-containing adaptors define the specificity of TLR signaling.
Journal Reference Authors Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
Title The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
Journal Reference Authors Aderem A, Smith KD.
Title A systems approach to dissecting immunity and inflammation.
Journal Reference Authors Banerjee A, Gerondakis S.
Title Coordinating TLR-activated signaling pathways in cells of the immune system.
Journal Reference Authors Loniewski KJ, Patial S, Parameswaran N.
Title Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Journal Reference Authors Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
Title Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and innate immunity.
Journal Related ssc04060 Cytokine-cytokine receptor interaction
ssc04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
