Entry
Name
Cytokine-cytokine receptor interaction - Sus scrofa (pig)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ssc04060 Cytokine-cytokine receptor interaction
Organism
Sus scrofa (pig) [GN:
ssc ]
Gene
100037306 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
100037976 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100038026 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100049688 TNFRSF11B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100127162 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100127163 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
100137085 IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067 ]
100152100 IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414 ]
100152504 IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414 ]
100153724 IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414 ]
100154938 IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414 ]
100156991 IL13RA2; interleukin-13 receptor subunit alpha-2 precursor [KO:K05077 ]
100157735 IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414 ]
100157766 IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414 ]
100217390 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A precursor [KO:K05149 ]
100271900 IL12RB1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
100511742 IL27RA; interleukin-27 receptor subunit alpha precursor [KO:K19598 ]
100513084 CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
100513161 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
100513263 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
100515668 BMP8A; LOW QUALITY PROTEIN: bone morphogenetic protein 8A [KO:K16622 ]
100515961 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
100516201 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X7 [KO:K05160 ]
100516458 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
100517087 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
100517818 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
100518821 CNTF; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420 ]
100518910 IL17RA; LOW QUALITY PROTEIN: interleukin-17 receptor A [KO:K05164 ]
100519368 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
100519398 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
100519468 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
100520196 LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
100521146 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X2 [KO:K05155 ]
100521706 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X2 [KO:K05147 ]
100524518 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100524628 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
100525607 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100525654 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100526213 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
100620339 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
100620374 BMP8B; LOW QUALITY PROTEIN: bone morphogenetic protein 8B [KO:K16622 ]
100620875 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
100621776 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
100622025 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154 ]
100622336 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100622457 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
100624969 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
100628318 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
100736831 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100737399 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
106508259 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
110257499 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
110257679 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
110260624 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
396657 IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
396658 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
396663 CCR7; C-C chemokine receptor type 7 precursor [KO:K04182 ]
396726 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
396735 CXCL16; C-X-C motif chemokine 16 precursor [KO:K10035 ]
396814 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
396826 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
396839 CSF3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
396900 AMCF-II; alveolar macrophage chemotactic factor 2 precursor [KO:K05506 ]
397020 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
397076 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
397078 TGFB1; transforming growth factor beta-1 precursor [KO:K13375 ]
397084 TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376 ]
397156 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
397178 IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
397179 IL18R1; interleukin-18 receptor 1 precursor [KO:K05173 ]
397208 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
397254 GDF11; growth/differentiation factor 11 precursor [KO:K22679 ]
397395 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
397400 TGFB3; transforming growth factor beta-3 precursor [KO:K13377 ]
397578 AMH; muellerian-inhibiting factor precursor [KO:K04665 ]
397614 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
397615 IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
399503 LIF; leukemia inhibitory factor precursor [KO:K05419 ]
399522 IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
399534 MSTN; growth/differentiation factor 8 precursor [KO:K05497 ]
404704 CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
406191 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
414285 GDF9; growth/differentiation factor 9 precursor [KO:K22673 ]
492315 BMP7; bone morphogenetic protein 7 precursor [KO:K16621 ]
493187 IL27; interleukin-27 subunit alpha precursor [KO:K22629 ]
494019 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
494459 CCL3L1; C-C motif chemokine 3-like 1 precursor [KO:K05408 ]
494460 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
494467 CXCL14; C-X-C motif chemokine 14 precursor [KO:K10033 ]
574053 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
574055 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
733692 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway