KEGG   PATHWAY: ssen03013
Entry
ssen03013                   Pathway                                
Name
Nucleocytoplasmic transport - Solea senegalensis (Senegalese sole)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ssen03013  Nucleocytoplasmic transport
ssen03013

Other DBs
GO: 0050658
Organism
Solea senegalensis (Senegalese sole) [GN:ssen]
Gene
122758090  nup188; nucleoporin NUP188 [KO:K14311]
122758182  tnpo1; transportin-1 [KO:K18752]
122758293  [KO:K14317]
122758296  xpo7; exportin-7 isoform X1 [KO:K18460]
122758437  nup155; nuclear pore complex protein Nup155 [KO:K14312]
122758699  nup54; nucleoporin p54 isoform X1 [KO:K14308]
122759337  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
122759650  [KO:K14325]
122760209  [KO:K15043]
122760779  nup50; nuclear pore complex protein Nup50 [KO:K14295]
122761009  nup93; nuclear pore complex protein Nup93 [KO:K14309]
122761254  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
122761261  xpo4; exportin-4 [KO:K25203]
122761447  [KO:K14319]
122761904  xpo1a; exportin-1 [KO:K14290]
122761937  [KO:K14290]
122762335  nup160; nuclear pore complex protein Nup160 [KO:K14303]
122762478  kpna3; importin subunit alpha-4 [KO:K23583]
122762546  kpna5; importin subunit alpha-6 [KO:K15042]
122762897  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
122765060  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
122765182  nup62l; nucleoporin 62 like [KO:K14306]
122765229  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
122765547  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
122765730  phax; phosphorylated adapter RNA export protein [KO:K14291]
122766064  nup37; nucleoporin Nup37 [KO:K14302]
122766139  acin1b; apoptotic chromatin condensation inducer 1b isoform X1 [KO:K12875]
122766414  tnpo3; transportin-3 [KO:K15436]
122766519  nup107; nuclear pore complex protein Nup107 [KO:K14301]
122766639  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
122766721  xpot; exportin-T isoform X1 [KO:K14288]
122766745  ipo8; importin-8 isoform X1 [KO:K18755]
122767566  ipo9; importin-9 [KO:K20224]
122767576  rae1; mRNA export factor isoform X1 [KO:K14298]
122768263  [KO:K18655] [EC:5.6.2.7]
122768459  sec13; protein SEC13 homolog [KO:K14004]
122768487  cse1l; exportin-2 [KO:K18423]
122769565  gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
122769631  thoc5; THO complex subunit 5 homolog [KO:K13174]
122769739  ipo11; importin-11 [KO:K25201]
122770534  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
122770582  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
122770896  [KO:K12881]
122771166  sumo2a; small ubiquitin like modifier 2a isoform X1 [KO:K12160]
122771217  [KO:K18727]
122771225  kpna7; importin subunit alpha-8 [KO:K15043]
122771232  nup133; LOW QUALITY PROTEIN: nuclear pore complex protein Nup133 [KO:K14300]
122771571  [KO:K15043]
122772083  ipo7; importin-7 [KO:K20223]
122772240  ahctf1; protein ELYS isoform X1 [KO:K25129]
122772946  kpna1; importin subunit alpha-5 [KO:K23940]
122773189  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
122773423  kpna4; importin subunit alpha-3 [KO:K23583]
122773686  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
122773775  [KO:K12875]
122773856  acin1a; calponin homology domain-containing protein DDB_G0272472 isoform X1 [KO:K12875]
122774215  rbm8a; RNA-binding protein 8A [KO:K12876]
122774425  ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
122775146  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
122775988  snupn; snurportin-1 [KO:K13151]
122776330  nup205; nuclear pore complex protein Nup205 [KO:K14310]
122776644  aaas; aladin isoform X1 [KO:K14320]
122776962  ipo4; importin-4 [KO:K20221]
122777226  ddx19a; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
122777415  pym1; partner of Y14 and mago [KO:K14294]
122777457  [KO:K13171]
122777517  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
122777969  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
122778498  nxt2; NTF2-related export protein 2 [KO:K14285]
122778570  thoc3; THO complex subunit 3 [KO:K12880]
122778648  tmem33; transmembrane protein 33 [KO:K20724]
122778712  [KO:K12882]
122778729  [KO:K09291]
122778957  ran; GTP-binding nuclear protein Ran [KO:K07936]
122778964  nxf1a; nuclear RNA export factor 1 isoform X1 [KO:K14284]
122779371  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
122779794  nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
122780046  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
122780336  magoh; protein mago nashi homolog [KO:K12877]
122780406  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
122780615  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
122780638  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
122780893  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
122781128  thoc1; THO complex subunit 1 [KO:K12878]
122781243  [KO:K25202]
122781602  si:dkey-37o8.1; elongation factor 1-alpha-like [KO:K03231]
122781866  [KO:K25202]
122781999  [KO:K03231]
122782170  [KO:K14289]
122782707  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
122782833  pnn; pinin [KO:K13114]
122783352  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
122784042  nup43; nucleoporin Nup43 [KO:K14305]
122784701  [KO:K14325]
122784883  kpnb1; importin subunit beta-1 [KO:K14293]
122784899  [KO:K18727]
122784940  nup85; nuclear pore complex protein Nup85 [KO:K14304]
122785123  thoc6; THO complex subunit 6 homolog [KO:K13175]
122785142  casc3; protein CASC3 [KO:K14323]
122785344  xpo6; exportin-6 [KO:K25204]
122785502  [KO:K10577]
122785786  rangap1a; ran GTPase-activating protein 1a isoform X1 [KO:K14319]
122785788  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
122785801  [KO:K12160]
122786000  nup42; nucleoporin NUP42 [KO:K14321]
122786270  [KO:K03231]
122786271  [KO:K03231]
122786466  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
122786473  kpnb3; importin-5 [KO:K20222]
122786478  kpna6; importin subunit alpha-7 [KO:K15042]
122786605  [KO:K03231]
122786606  [KO:K03231]
122786917  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ssen03015  mRNA surveillance pathway
KO pathway
ko03013   

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