KEGG   PATHWAY: xgl04217
Entry
xgl04217                    Pathway                                
Name
Necroptosis - Xiphias gladius (swordfish)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
xgl04217  Necroptosis
xgl04217

Organism
Xiphias gladius (swordfish) [GN:xgl]
Gene
120783113  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
120783250  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
120784018  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120784104  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
120784265  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
120784271  [KO:K05414]
120784276  [KO:K05414]
120784912  [KO:K12197]
120785048  stat5a; signal transducer and activator of transcription 5A [KO:K11224]
120785053  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
120785228  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
120785314  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
120785403  slc25a5; ADP/ATP translocase 2 [KO:K05863]
120785433  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
120785458  cd40lg; CD40 ligand [KO:K04389]
120785816  [KO:K04725] [EC:2.3.2.27]
120786357  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120788025  [KO:K02159]
120788147  [KO:K12195]
120788375  [KO:K00522] [EC:1.16.3.1]
120788415  [KO:K02159]
120788807  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
120789116  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
120789117  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
120789344  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
120789625  chmp5b; charged multivesicular body protein 5 [KO:K12198]
120789832  [KO:K11974] [EC:2.3.2.31]
120789833  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
120789915  [KO:K02161]
120789937  chmp4c; charged multivesicular body protein 4c [KO:K24782]
120789938  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
120790035  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
120790493  [KO:K12196]
120790633  jak3; tyrosine-protein kinase JAK2 [KO:K11218] [EC:2.7.10.2]
120790858  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
120790859  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120790892  glulb; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
120790939  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120791052  fth1a; ferritin, heavy polypeptide 1a [KO:K00522] [EC:1.16.3.1]
120791185  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
120791353  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120791739  [KO:K01370] [EC:3.4.22.36]
120791769  [KO:K11251]
120792406  hmgb1b; high mobility group protein B1b [KO:K10802]
120792776  [KO:K08847] [EC:2.7.11.1]
120793048  bida; BH3 interacting domain death agonist [KO:K04726]
120793266  spata2l; spermatogenesis associated 2-like [KO:K17595]
120793443  [KO:K12194]
120793496  chmp1a; charged multivesicular body protein 1a [KO:K12197]
120793580  fth1b; ferritin, heavy polypeptide 1b [KO:K00522] [EC:1.16.3.1]
120793656  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
120793680  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120793730  cylda; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
120793742  [KO:K08849] [EC:2.7.11.1]
120793934  chmp2a; charged multivesicular body protein 2a [KO:K12191]
120793967  [KO:K04515] [EC:2.7.11.17]
120794184  glud1b; glutamate dehydrogenase 1b [KO:K00261] [EC:1.4.1.3]
120794379  zgc:56095; ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
120794394  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
120794508  [KO:K05414]
120794519  [KO:K05414]
120794630  [KO:K11224]
120794736  chmp6b; charged multivesicular body protein 6 [KO:K12195]
120794839  [KO:K15040]
120795009  chmp3; charged multivesicular body protein 3 [KO:K12193]
120795111  zgc:153993; apoptosis regulator BAX [KO:K02159]
120795358  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
120795438  [KO:K04721]
120795618  [KO:K01367] [EC:3.4.22.52]
120795730  [KO:K01367] [EC:3.4.22.52]
120796110  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120796120  [KO:K16342] [EC:3.1.1.4]
120796127  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120796205  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120796267  [KO:K17595]
120796274  [KO:K03853] [EC:3.4.22.53]
120796275  [KO:K03853] [EC:3.4.22.53]
120796284  [KO:K00261] [EC:1.4.1.3]
120796298  [KO:K01367] [EC:3.4.22.52]
120796336  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120796346  ifngr1l; interferon gamma receptor 1-like isoform X1 [KO:K05132]
120796352  [KO:K11251]
120796399  pygb; glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
120796570  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
120796597  [KO:K16195] [EC:2.7.11.1]
120796825  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
120797023  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
120797123  [KO:K04515] [EC:2.7.11.17]
120797155  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
120797166  capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
120797346  [KO:K00688] [EC:2.4.1.1]
120797378  [KO:K11251]
120797916  [KO:K21421] [EC:1.-.-.-]
120798154  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
120798581  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
120798672  [KO:K20894]
120799033  chmp5a; charged multivesicular body protein 5 [KO:K12198]
120799083  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
120799085  [KO:K04398] [EC:3.4.22.61]
120799229  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
120799277  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
120799349  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
120799354  [KO:K11974] [EC:2.3.2.31]
120799358  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
120799678  [KO:K11974] [EC:2.3.2.31]
120799709  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120799791  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
120799817  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120799962  [KO:K01367] [EC:3.4.22.52]
120799991  [KO:K01915] [EC:6.3.1.2]
120799992  [KO:K01915] [EC:6.3.1.2]
120800137  ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
120800453  capn2l; calpain 2, (m/II) large subunit, like isoform X1 [KO:K03853] [EC:3.4.22.53]
120800454  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
120800455  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
120800498  fadd; protein FADD [KO:K02373]
120800594  slc25a4; ADP/ATP translocase 1 [KO:K05863]
120800753  tlr3; toll-like receptor 3 [KO:K05401]
120800849  [KO:K17065] [EC:3.6.5.5]
120801162  [KO:K04724]
120801383  stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
120801444  ifngr2; interferon gamma receptor 2 [KO:K05133]
120801616  [KO:K11220]
120801861  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
120802030  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
120802163  hmgb1a; high mobility group protein B1a [KO:K10802]
120802245  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120802303  [KO:K11251]
120802355  [KO:K11251]
120802411  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
120802521  [KO:K11251]
120802525  [KO:K11251]
120802526  [KO:K11251]
120802584  [KO:K11251]
120802683  [KO:K11251]
120802704  si:dkey-251i10.1; ADP/ATP translocase 3 [KO:K05863]
120802729  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120802744  [KO:K11251]
120802830  [KO:K11251]
120802833  [KO:K12197]
120802854  [KO:K01367] [EC:3.4.22.52]
120802962  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120803051  [KO:K00688] [EC:2.4.1.1]
120803087  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
120803337  spata2; spermatogenesis-associated protein 2 [KO:K17595]
120803447  stat6; signal transducer and activator of transcription 6 [KO:K11225]
120803501  usp21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
120804310  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120804433  [KO:K12194]
120804653  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
120804700  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
120804991  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
120805088  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120805095  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
120805168  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120805225  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120805320  [KO:K04519]
120805321  [KO:K04519]
120805506  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
120805670  [KO:K11251]
120805791  ppiaa; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
120806021  il1b; interleukin-1 beta [KO:K04519]
120806100  [KO:K04515] [EC:2.7.11.17]
120806138  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
120806199  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120806471  [KO:K01915] [EC:6.3.1.2]
120806563  [KO:K03173] [EC:2.3.2.27]
120806581  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
120806589  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
120806741  ppiab; peptidylprolyl isomerase Ab (cyclophilin A) isoform X1 [KO:K03767] [EC:5.2.1.8]
120806753  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
120806812  [KO:K11251]
120806911  cyldb; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
120807228  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
120807379  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
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Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
xgl00250  Alanine, aspartate and glutamate metabolism
xgl04210  Apoptosis
KO pathway
ko04217   

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