KEGG   PATHWAY: zvi04060
Entry
zvi04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Zootoca vivipara (common lizard)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
zvi04060  Cytokine-cytokine receptor interaction
zvi04060

Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118075212  EPOR; erythropoietin receptor [KO:K05079]
118075236  [KO:K05414]
118075241  IFNK; interferon kappa [KO:K05414]
118075339  IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
118075669  LIF; leukemia inhibitory factor [KO:K05419]
118076099  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
118076151  TNF; tumor necrosis factor [KO:K03156]
118076237  [KO:K13376]
118076513  IL12B; interleukin-12 subunit beta [KO:K05425]
118077061  [KO:K05058]
118077074  [KO:K05057]
118077107  [KO:K05414]
118077125  PRLR; prolactin receptor [KO:K05081]
118077188  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
118077233  GHR; growth hormone receptor isoform X1 [KO:K05080]
118077254  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
118077290  BMP4; bone morphogenetic protein 4 [KO:K04662]
118077302  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
118077310  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
118077334  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
118077360  [KO:K05512]
118077399  [KO:K05423]
118078074  [KO:K05131]
118078248  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
118078281  [KO:K05423]
118078290  [KO:K05479]
118078298  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
118078304  [KO:K05469]
118078432  INHBE; inhibin beta E chain [KO:K22689]
118078763  [KO:K05149]
118078798  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
118079071  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
118079084  [KO:K12672]
118079289  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
118079300  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
118079346  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
118079354  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
118079474  [KO:K05487]
118079601  GDF11; growth/differentiation factor 11 [KO:K22679]
118080284  IL17B; interleukin-17B [KO:K05490]
118080336  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
118080371  CXCL14; C-X-C motif chemokine 14 isoform X1 [KO:K10033]
118080418  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118080707  IL17RB; interleukin-17 receptor B [KO:K05165]
118080885  CRELD1; protein disulfide isomerase CRELD1 isoform X1 [KO:K05166]
118080887  [KO:K05168]
118080888  [KO:K05168]
118081440  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
118081589  [KO:K05426]
118081749  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118082067  IFNGR1; interferon gamma receptor 1 [KO:K05132]
118082068  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
118082357  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
118082499  BMP2; bone morphogenetic protein 2 [KO:K21283]
118082601  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
118082624  [KO:K05050]
118082804  [KO:K05494]
118082816  CCR6; C-C chemokine receptor type 6 [KO:K04181]
118082871  GDF7; growth/differentiation factor 7 [KO:K20013]
118083182  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118083425  [KO:K10032]
118083490  [KO:K10032]
118083708  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
118083758  BMP3; bone morphogenetic protein 3 isoform X1 [KO:K05496]
118083815  CD40LG; CD40 ligand [KO:K03161]
118083897  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
118084044  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
118084117  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
118084263  EDA; ectodysplasin-A [KO:K05480]
118084331  [KO:K05433]
118084549  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
118084703  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
118084879  IFNGR2; interferon gamma receptor 2 [KO:K05133]
118084974  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118084975  [KO:K05135]
118084996  [KO:K04386]
118084997  [KO:K04387]
118085005  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
118085219  [KO:K05066]
118085220  [KO:K05507]
118085357  [KO:K05131]
118085358  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
118085398  [KO:K05172]
118085456  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
118085472  IL17D; interleukin-17D [KO:K05492]
118085745  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
118085746  IL18R1; interleukin-18 receptor 1 [KO:K05173]
118085774  [KO:K05131]
118085792  IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174]
118085958  [KO:K21283]
118085976  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
118086030  [KO:K05060]
118086048  GDF15; growth/differentiation factor 15 [KO:K05504]
118086063  [KO:K21283]
118086365  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
118086683  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118086764  [KO:K16622]
118086790  IL17C; interleukin-17C [KO:K05491]
118086854  [KO:K04519]
118086933  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
118087121  [KO:K05141]
118087249  BMP10; bone morphogenetic protein 10 [KO:K22670]
118087291  [KO:K04188]
118087305  [KO:K04188]
118087328  IL1B; interleukin-1 beta [KO:K04519]
118087473  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
118087510  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
118087634  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
118087641  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
118087748  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118087764  IFNLR1; interferon lambda receptor 1 [KO:K05140]
118087808  CX3CL1; fractalkine isoform X1 [KO:K05508]
118087838  [KO:K04722]
118087939  EBI3; interleukin-27 subunit beta [KO:K24476]
118087957  AMH; muellerian-inhibiting factor [KO:K04665]
118088490  GDF5; growth/differentiation factor 5 [KO:K04664]
118088495  LEPR; leptin receptor [KO:K05062]
118088579  IL10; interleukin-10 [KO:K05443]
118088620  BMP7; bone morphogenetic protein 7 [KO:K16621]
118088771  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
118088941  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
118089037  NGF; beta-nerve growth factor [KO:K02582]
118089128  IL23R; interleukin-23 receptor [KO:K05065]
118089129  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
118089489  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
118089521  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
118089646  CNTF; ciliary neurotrophic factor [KO:K05420]
118089785  BMP6; bone morphogenetic protein 6 [KO:K16620]
118090085  PRL; prolactin [KO:K05439]
118090087  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
118090437  GDF6; growth/differentiation factor 6 [KO:K20012]
118090515  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
118090640  INHA; inhibin alpha chain [KO:K05500]
118090827  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
118090889  LEP; leptin [KO:K05424]
118091031  [KO:K05074]
118091036  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
118091065  IL17RA; interleukin-17 receptor A [KO:K05164]
118091115  [KO:K05439]
118091122  IL22; interleukin-22 [KO:K05445]
118091248  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
118091378  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
118091505  [KO:K04687]
118091574  [KO:K05050]
118091650  [KO:K05050]
118091780  CXCR6; C-X-C chemokine receptor type 6 isoform X1 [KO:K04191]
118091848  ACKR4; atypical chemokine receptor 4 [KO:K04186]
118091869  CCR4; C-C chemokine receptor type 4 [KO:K04179]
118091890  [KO:K02583]
118091917  [KO:K04180]
118091918  [KO:K04180]
118091930  INHBB; inhibin beta B chain [KO:K22687]
118091951  [KO:K04388] [EC:2.7.11.30]
118092169  XCR1; chemokine XC receptor 1 [KO:K04193]
118092171  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
118092211  [KO:K04180]
118092219  [KO:K04180]
118092223  INHBA; inhibin beta A chain [KO:K04667]
118092352  IL6; interleukin-6 [KO:K05405]
118092373  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118092384  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
118092519  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118092702  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
118093019  [KO:K05073]
118093079  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
118093081  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
118093089  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
118093190  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
118093300  IL21R; interleukin-21 receptor [KO:K05075]
118093461  CCL20; C-C motif chemokine 20 [KO:K14625]
118093614  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118093688  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
118094072  THPO; thrombopoietin [KO:K06854]
118094562  CCR10; C-C chemokine receptor type 10 [KO:K04185]
118094575  GH1; somatotropin [KO:K05438]
118094733  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
118094889  [KO:K10035]
118094983  [KO:K10030]
118095028  CCR7; C-C chemokine receptor type 7 [KO:K04182]
118095060  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
118095098  EPO; erythropoietin [KO:K05437]
118095103  MSTN; growth/differentiation factor 8 [KO:K05497]
118095121  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
118095122  TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
118095131  [KO:K05505]
118095137  [KO:K05423]
118095352  [KO:K24382]
118095483  [KO:K22629]
118095503  IL11; interleukin-11 [KO:K05417]
118095534  CTF1; cardiotrophin-1 [KO:K24382]
118095750  IL25; interleukin-25 [KO:K05493]
118095792  [KO:K05076]
118095893  [KO:K05149]
118096082  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
118096116  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
118096401  GDF2; growth/differentiation factor 2 [KO:K05503]
118096423  CXCL12; stromal cell-derived factor 1 [KO:K10031]
118096518  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118096739  [KO:K21093]
118096740  [KO:K21095]
118096811  [KO:K05134]
118096882  ACKR3; atypical chemokine receptor 3 [KO:K04304]
118097010  [KO:K12964]
118097076  [KO:K05482]
118097137  [KO:K04722]
118097157  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
118097270  [KO:K12499]
118097299  [KO:K12499]
118097304  [KO:K05483]
118097305  [KO:K05488]
118097312  [KO:K05487]
118097317  NODAL; nodal homolog [KO:K04666]
118097352  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
118097870  [KO:K06454]
118097914  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
118097922  [KO:K03158]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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