KEGG    Network variation - Human immunodeficiency virus 1 (HIV-1)
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ENTRYnt06161
NameHuman immunodeficiency virus 1 (HIV-1)
CategoryDisease view; Viral infection
Pathwayhsa05170 Human immunodeficiency virus 1 infection
GenomeT40001
DiseaseH01563 HIV infection
H00406 Acquired immunodeficiency syndrome (AIDS)
Display drug-target relation   disease type
TLR signaling
N00435    (TLR1,TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)IKKNFKBIANFKB(TNF,IL6,IL12A,IL1..
N00436              TatNFKB(TNF,IFNA,IFNB1)
N00437              VpuNFKB
N00438    (TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)(MEK,MKK3/6,MKK4/7..(ERK,p38,JNK)AP1
N00439            NefERK
 
CGAS-STING signaling
N00395    DNACGAScGAMPSTING1TBK1IRF3(IFNA,IFNB)
N00440            (Vpu,Vif,Vpr)IRF3
 
TNF signaling
N00446      TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK4/7JNKAP1
N00447              (Vpr,Tat)JNKAP1
N00444      TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK3/6MAPK14MSK1/2CREB
N00445              (Tat,Nef)MAPK14
N00151      TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00441      EnvTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00442        Nef(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00443                (Vpr,Nef,Tat)NFKB
 
Chemokine signaling
N00401    CXCL12CXCR4GNAQ(PLCB,PLCG)IP3Ca2+CALM=CNNFAT
N00432    Env(CXCR4,CCR5)GNAQ
N00430    CXCL12CXCR4GNAIPI3KPIP3AKTBAD
N00431    Env(CXCR4,CCR5)GNAI
N00433    CXCL12CXCR4GNB/GRACPAK1LIMK1CFL
N00434    Env(CXCR4,CCR5)GNB/G
 
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00461        NefMHCI
 
Cell cycle
N00455        (ATM,ATR)CHEK1/2CDC25B/C(CCNB+CDK1)
N00456    Vpr=(DCAF1+DDB1+CUL4)ATRCHEK1CDC25C(CCNB+CDK1)
N00458          VprCDC25C
N00457            Vpr(CCNB+CDK1)
N00459        ATRCHEK1WEE1(CCNB+CDK1)
N00460          VprWEE1(CCNB+CDK1)
 
Apoptosis
N00146      (FASLG,TNFSF10)(FAS,TNFRSF10B)FADD(CASP8,CASP10)BID(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00448    (Tat,Nef)FASLG
N00449          (Tat,Nef)CASP8BID(BAX,BAK1)CYCS=APAF1CASP9CASP3
N00098            (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00452          NefBAD
N00451            Tat(BCL2,BCL2L1)
N00453            VprBCL2
N00450              TatBAX
N00454              VprBAX